Effects of Physical Activity on Hippocampal Neurogenesis

体力活动对海马神经发生的影响

• 批准号: 7251927
• 负责人: Alexis M. Stranahan
• 金额: $ 3.8万
• 依托单位: PRINCETON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7251927
• 关键词: Adrenal Glands; Adult; Affect; Brain; Bromodeoxyuridine; Cardiovascular system; Cell Proliferation; D Aspartate; Data; Dementia; Elderly; Elevation; Environment; Environmental Risk Factor; Exercise; Fellowship; Frequencies; Goals; Hippocampus (Brain); Histone H3; Incidence; Individual; Learning; Measures; Mus; Names; Neurodegenerative Disorders; Neurons; Numbers; Ovarian hormone; Physical activity; Physiological; Prevention; Process; Rattus; Receptor Activation; Research; Research Proposals; Role; Running; Steroids; Stress; Structure; Thymidine; Time; analog; aspartate receptor; day; dentate gyrus; neurogenesis; psychologic

DESCRIPTION (provided by applicant): The brain continues to generate new neurons in the hippocampus throughout adulthood. The process of neurogenesis is influenced by environmental factors such as learning, stress, spatial complexity, and physical activity. The proposed research will explore the control of neurogenesis by wheel running activity, and investigate the temporal and physiological parameters of this phenomenon. In addition, the volitional aspect of exercise will be examined using forced treadmill and voluntary running wheel activity. The thymidine analog 5-bromodeoxyuridine (BrdU) is typically used in studies of cell proliferation and survival in the hippocampus. However, when studying environmental factors that elevate the circulatory system, the issue of availability causes difficulty in interpretation of results. To this end, immunolabeling for the endogenous markers Ki-67 and phospho-histone H3 will be applied to provide a measure of exercise-induced neurogenesis that is not affected by systemic elevation. Physical activity has been correlated with a lower incidence of dementia in older adults, and the data from studies of exercise-induced neurogenesis may one day be applied to the prevention or treatment of neurodegenerative disease.

描述（由申请人提供）：在整个成年期，大脑的海马体中不断产生新的神经元。神经发生过程受到学习、压力、空间复杂性和身体活动等环境因素的影响。拟议的研究将探索轮跑活动对神经发生的控制，并研究这种现象的时间和生理参数。此外，还将使用强制跑步机和自愿跑轮活动来检查运动的意志方面。胸苷类似物 5-溴脱氧尿苷 (BrdU) 通常用于海马细胞增殖和存活的研究。然而，在研究提升循环系统的环境因素时，可用性问题导致结果解释困难。为此，将应用内源性标记物 Ki-67 和磷酸组蛋白 H3 的免疫标记来提供不受全身升高影响的运动诱导神经发生的测量。身体活动与老年人痴呆症的发病率较低有关，运动诱发的神经发生研究的数据有一天可能会应用于预防或治疗神经退行性疾病。

项目成果

Social isolation delays the positive effects of running on adult neurogenesis.

社会隔离会延迟跑步对成人神经发生的积极影响。

• 发表时间: 2006-04
• 影响因子: 25
• 作者: Stranahan, Alexis M;Khalil, David;Gould, Elizabeth
• 通讯作者: Gould, Elizabeth

Physiological variability in brain-derived neurotrophic factor expression predicts dendritic spine density in the mouse dentate gyrus.

脑源性神经营养因子表达的生理变异可预测小鼠齿状回的树突棘密度。

• 发表时间: 2011-05-09
• 影响因子: 2.5
• 作者: Stranahan; Alexis M
• 通讯作者: Alexis M

Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons.

糖尿病通过糖皮质激素介导的对新神经元和成熟神经元的影响损害海马功能。

• 发表时间: 2008-03
• 影响因子: 25
• 作者: Stranahan, Alexis M;Arumugam, Thiruma V;Cutler, Roy G;Lee, Kim;Egan, Josephine M;Mattson, Mark P
• 通讯作者: Mattson, Mark P

Hippocampal gene expression patterns underlying the enhancement of memory by running in aged mice.

海马基因表达模式是老年小鼠跑步增强记忆力的基础。

• 发表时间: 2010-11
• 影响因子: 4.2
• 作者: Stranahan, Alexis M;Lee, Kim;Becker, Kevin G;Zhang, Yonqing;Maudsley, Stuart;Martin, Bronwen;Cutler, Roy G;Mattson, Mark P
• 通讯作者: Mattson, Mark P

Central mechanisms of HPA axis regulation by voluntary exercise.

通过自愿运动调节 HPA 轴的中心机制。

• 发表时间: 2008
• 影响因子: 3.5
• 作者: Stranahan, Alexis M;Lee, Kim;Mattson, Mark P
• 通讯作者: Mattson, Mark P