FACULTY DVMT & CLIN BEHV RES CORES

教职人员 DVMT

• 批准号: 7961262
• 负责人: CARMEN D ZORRILLA
• 金额: $ 56.87万
• 依托单位: UNIVERSITY OF PUERTO RICO MED SCIENCES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-24 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7961262
• 关键词: AIDS/HIV problem; Adherence; Advisory Committees; Affect; American; Attention; Clinical; Clinical Psychology; Clinical Research; Collaborations; Communities; Computer Retrieval of Information on Scientific Projects Database; Data; Development; Environment; Evaluation; Event; Faculty; Funding; General Population; Grant; HIV; Health Personnel; Hispanics; Homelessness; Human immunodeficiency virus test; Institution; Interdisciplinary Study; Internet; Intervention; Intervention Studies; Island; Journals; Laboratories; Latino; Lead; Measures; Mentors; Mentorship; Morbidity - disease rate; National Center for Research Resources; Outcome; Pharmaceutical Preparations; Pharmacy Schools; Pilot Projects; Population; Populations at Risk; Prevention; Preventive Intervention; Prostitution; Public Health; Public Health Schools; Publications; Publishing; Puerto Rican; Puerto Rico; Recording of previous events; Reporting; Research; Research Activity; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Risk Behaviors; Risk Reduction; School Dentistry; Schools; Secondary Prevention; Series; Services; Source; Staging; Stigmata; Students; Training; Translational Research; United States National Institutes of Health; Universities; Violence; Woman; abuse neglect; acronyms; base; burden of illness; career; drug addict; essays; health disparity; innovation; instrument; interest; medical schools; programs; sex; social stigma

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction The activities of the Center have been carried out as proposed in our original plan. All of the originally proposed research projects (3) are during their last stages and developmental funding was provided to several pilot projects during the past year. In total there are 9 ongoing or active projects. We will be submitting a proposal for an additional year of partial funding ("bridge") to allow the Center to continue activities towards renewal or further funding as deemed advisable by the NCRR. We are including a list of 28 scientific publications from the key investigators and faculty involved in the Center. As part of this report we are describing the activities of the Core groups: the Faculty Development and Progress Evaluation Core, the Data Core and DSMB, both Internal and External Advisory Committees and the Laboratory Core. A report on the developmental research projects is included. II. Specific Aims of the Center At the end of the first funding cycle we completed all of our specific aims for this Center as follows: 1.To establish a Comprehensive Center with the purpose of enhancing the clinical and translational research capabilities in Puerto Rico through a collaborative effort between the three accredited Medical Schools in PR, the UPR School of Public Health and the UPR School of Dentistry to establish a "tradition" of collaboration The PR-CCHD was successful in establishing and retaining collaborators from the three accredited medical schools in PR plus several other programs adding to a total of six professional schools. The UPR School of Public Health, the UPR School of Dentistry, the Ponce School of Medicine Program of Clinical Psychology, the NOVA Southeastern School of Pharmacy and Iniciativa Comunitaria de Investigacion (ICI-Spanish acronym) were included as part of the collaborators. So, during the first funding cycle, the number of collaborating professional schools increased from the original three to six and one Community Based Organization (CBO). The junior investigators were encouraged to establish inter-institutional partnerships and research teams and this activity was enhanced by the mentoring and infrastructure support provided by the center. This is a unique and innovative Center since it clearly establishes a mechanism for collaborative research that integrates into one central concept the salient activities at each participating institution: a Data Center, a Laboratory and a Clinical Research Center. Although integration and collaboration has been the target of many initiatives, it is through the webbing of resources that true collaborative research was established as a tradition and not as an isolated event. This (tradition or culture of collaboration) will perhaps be one of the biggest and most important long-term accomplishments of this proposal. This tradition of collaboration stared with the lead investigators, but will be cemented by the long-term participation of junior investigators who will initiate their careers with a different paradigm: that successful collaboration can happen even within "competing" institutions. This will be in the benefit of all involved. 2. To develop sustainable, replicable and culturally appropriate prevention and/or intervention research programs targeted to the Puerto Rican population to decrease the burden of disease. Several prevention interventions were developed as part of the activities of the center, the most salient was the development of the Hispanic/Latino Respect (a risk reduction intervention using the rapid HIV test). 3. To develop and validate a series of culturally appropriate instruments to measure diverse variables such as but not limited to: socio-demographic, HIV risk behaviors, co-morbidities, adherence, stigma, history of violence and abuse; and to make them available to interested investigators and health care providers. Instruments were developed to adequately measure perceived stigma as well as abuse and neglect among populations at-risk for HIV/AIDS. 4. To enhance the opportunities for multidisciplinary research collaborations between the island institutions and those with a more established research programs in the US mainland. Collaborations with NOVA Southeastern University and other programs were initiated. 5. To establish a Mentorship program for junior investigators with resources from both local and abroad (PR and US institutions) and to create the stimulating academic environment that will encourage students and fellows to pursue a career in health disparities research and in particular, HIV/AIDS research. Based on the outcomes and the impact of the training and development activities performed in the last four years, we developed a mentoring/educational framework. An analytic essay/article was published in the American Journal of Public Health. (Rabionet, S, Santiago, L, and Zorrilla, C. 2009, Vol 99, No S1 65-70). In addition to the previously mentioned activities, another partner was included in the research activities: Iniciativa Comunitaria de Investigacion (ICI) is a community-based organization established in 1991 to provide comprehensive primary and secondary prevention and support services to people affected with HIV/AIDS. It originated from the CPCRA (Community Participatory Clinical Research Activities) funded by NIH to bring research activities to the community. ICI serves the general population with special attention to marginalized groups such as, homeless, drug addicts, and women who engage in commercial sex worker (sex for drugs/money).

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 介绍 该中心的活动已按照我们的原始计划中的建议进行。所有最初建议的研究项目（3）均在其最后阶段，并且在过去一年中向多个试点项目提供了发展资金。总共有9个正在进行的或活跃的项目。我们将提交一项额外的部分资金（“桥”）的提案，以允许该中心继续进行续订或进一步的资金，如NCRR所建议的。 我们包括参与该中心的主要调查员和教职员工的28个科学出版物的清单。作为本报告的一部分，我们描述了核心群体的活动：教师发展和进度评估核心，数据核心和DSMB，包括内部和外部咨询委员会以及实验室核心。包括有关发展研究项目的报告。 ii。中心的具体目标 在第一个资金周期结束时，我们完成了该中心的所有具体目标，如下所示： 1.建立一个全面的中心，目的是通过在PR，UPR公共卫生学院和UPR牙科学院的三所认可的医学院之间的合作努力来增强波多黎各的临床和转化研究能力，以建立合作的“传统” PR-CCHD成功地从公关中三所获得认可的医学院建立和保留了合作者，以及其他几个计划，总共增加了六所专业学校。 UPR公共卫生学院，UPR牙科学院，Ponce医学学院临床心理学计划，Nova东南药学院和Iniciativa Comunitaria de Resjectionacion（ICI-Spanish primy）（ICI-Spanish首字母缩写）作为合作者包括在内。因此，在第一个融资周期中，合作的专业学校的数量从原始的三个增加到六个，一个基于社区的组织（CBO）。 鼓励初级调查人员建立机构间伙伴关系和研究团队，该中心提供的指导和基础设施支持增强了这项活动。 这是一个独特而创新的中心，因为它清楚地建立了一种合作研究的机制，该机制将每个参与机构的显着活动集成到一个中心概念：一个数据中心，一个实验室和临床研究中心。尽管整合和协作一直是许多举措的目标，但通过资源的织带，真正的合作研究是作为一种传统而不是孤立的事件确立的。这种（合作的传统或文化）也许是该提议中最大，最重要的长期成就之一。这种合作的传统凝视着首席调查员，但初级调查人员的长期参与将巩固他们的职业生涯，即使在“竞争”机构中，成功的合作也可以发生。这将是所有参与者的好处。 2。开发可持续的，可复制和适当的预防和/或干预研究计划，该计划针对波多黎各人口减轻疾病负担。 作为该中心活动的一部分，开发了几种预防干预措施，最突出的是西班牙裔/拉丁美洲裔尊重的发展（使用快速HIV测试降低风险干预）。 3。开发和验证一系列文化上适当的工具来衡量不同的变量，例如但不限于：社会人口统计学，艾滋病毒风险行为，合并症，遵守，污名，暴力和虐待历史；并将其提供给感兴趣的研究人员和医疗保健提供者。 开发了仪器，以充分衡量感知到的污名，以及在艾滋病毒/艾滋病危险中的滥用和忽视。 4。为了增强岛屿机构与在美国大陆具有更富裕的研究计划的岛屿机构之间进行多学科研究合作的机会。 启动了与Nova东南大学和其他计划的合作。 5。为初级调查员建立指导计划，并拥有来自本地和国外（公关和美国机构）的资源，并创建令人兴奋的学术环境，以鼓励学生和研究员从事健康差异研究的职业，尤其是HIV/AIDS研究。 根据过去四年中培训和发展活动的结果和影响，我们开发了一个指导/教育框架。 《美国公共卫生杂志》发表了一篇分析论文/文章。 （Rabionet，S，Santiago，L和Zorrilla，C.2009，第99卷，无S1 65-70）。 除了前面提到的活动外，研究活动还包括另一个合作伙伴：Iniciativa comunitaria de Respejioncion（ICI）是一个基于社区的组织，成立于1991年，旨在为受HIV/AIDS影响的人们提供全面的初级和次要预防和支持服务。它起源于NIH资助的CPCRA（社区参与式临床研究活动），旨在为社区带来研究活动。 ICI特别关注边缘化群体，例如无家可归的吸毒者和从事商业性工作工作者（毒品/金钱的性生活）的妇女。