C3: Tissue and Histopathology

C3：组织和组织病理学

基本信息

批准号：
7892549
负责人：
THOMAS E. CAREY
金额：
$ 24.91万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/7892549
关键词：
Aliquot Anatomy Antibodies Antigens Archives Bar Codes Basic Science Behavior Biological Biological Models Biopsy Biopsy Specimen Build-it Calibration Cancer Biology Cancer Center Cancer cell line Caring Cell Culture Techniques Cell Line Cell Separation Cells Characteristics Cisplatin Clinical Clinical Data Clinical Trials Coagulation Process Collaborations Collection Communities Community Clinical Oncology Program Confidentiality of Patient Information Consent Consult Consultations DNA DNA Fingerprinting Data Databases Decision Making Detection Development Diagnosis Diagnostic Ensure Equipment and supply inventories Event Excision Experimental Designs Experimental Models Family history of Fibrin Formalin Freezing Fresh Tissue Funding Future Gene Amplification Gene Dosage Gene Expression Gene Mutation Growth Head and Neck Cancer Head and Neck Surgeon Head and neck structure Health behavior Health system Histologic Histopathology Human Human Papillomavirus Image Immune response Immunohistochemistry In Situ Hybridization In Vitro Individual Informed Consent Internet Investigation Knowledge Label Laboratories Laboratory Research Link Malignant Neoplasms Measures Messenger RNA Methodology Methods Michigan Microdissection Microsatellite Repeats Mitochondria Molecular Morbidity - disease rate Mutation Mycoplasma Nature Neck Dissection Neoplasm Metastasis Newly Diagnosed Normal tissue morphology Nurses Online Systems Operative Surgical Procedures Organ Outcome Paraffin Paraffin Embedding Pathologist Pathology Patient Care Patients Pilot Projects Population Preparation Prevention Prevention strategy Primary Neoplasm Process Prostate Publications Quality Control Quarantine RNA Radiation Tolerance Radiosurgery Reagent Records Recurrence Relapse Reproducibility Reproduction spores Research Research Ethics Committees Research Personnel Research Project Grants Research Support Resistance Resources Retrieval Review Committee Saliva Sampling Scientist Screening procedure Secure Serum Services Site Slide Small Interfering RNA Specimen Staining method Stains Standardization Surgeon System TP53 gene Testing Therapeutic Time Tissue Microarray Tissue Procurements Tissues Translational Research Tumor Cell Line Tumor Tissue Universities Visit Whole Blood Wolves Work Writing austin base caregiving cell behavior conventional therapy cost data management demographics design effective therapy established cell line experience flexibility follow-up head and neck cancer patient in vivo Model innovation interest knock-down knowledge base lymph nodes malignant mouth neoplasm meetings new technology novel oncology programs repository research study response sample collection success tissue fixing tissue/cell culture tool tumor

项目摘要

Extending our understanding of the molecular events in cancer growth and progression requires detailed correlations of molecular characteristics with biologic tumor behavior and host response These data are essential to the design of new, more effective therapies, better application of conventional treatments and prevention strategies for tumor relapse. An essential prerequisite is availability of complete clinical, demographic, and treatment data that are integrated with molecular data from well-characterized human tumor and serum samples as well as our unique panel of head and neck cancer cell lines that serve as in vitro and in vivo model systems for investigation of novel agents or mechanisms. To support the research efforts of investigators in this UM-HN SPORE program, the NCI and other SPORE programs, a comprehensive tissue procurement, processing, storage, head and neck cancer cell line bank, distribution process and data management system is proposed. This core represents collaborative efforts of basic scientists, anatomic pathologists, clinicians and data managers. It builds our prior experience in collecting, storing and distributing tissues among our Head and Neck Oncology Program Investigators and the experience of our UM Cancer Center Tissue and Tumor procurement Core, as well as cooperation with the UM Prostate SPORE. Detailed distribution rules and standardized processing for whole blood, serum, fresh tissue with proper imbedding and frozen storage, tissue in RNA Later, paraffin embedded tissue, immunohistology, tissue microarray, and cell culture preparation are included. A detailed descriptive relational database including tumor characteristics, patient demographics, health behaviors, co-morbidities, family history, treatment and follow-up data is linked with the tumor repository data and each investigator's laboratory by a secure Head and Neck web-based database called BioDBx that is interfaced with the clinical UM Health System data repository (Care Web). Flexibility is provided to meet specific needs of any project and incorporation of new technologies for future projects or collaborations with outside investigators. We have proposed a model system that will be a resource that maximizes superb tissue-clinical data availability for studying these relatively uncommon head and neck cancers by the entire NCI SPORE community.

扩展我们对癌症生长和进展中分子事件的理解需要详细分子特征与生物肿瘤行为和宿主反应的相关性这些数据是对于新的，更有效的疗法的设计至关重要的，更好地应用常规治疗和预防肿瘤复发的策略。必不可少的先决条件是完全临床，人口统计学以及与特征良好的人类分子数据集成的治疗数据肿瘤和血清样品以及我们独特的头颈癌细胞系的独特面板，如在体外和体内模型系统，用于研究新型药物或机制。支持研究调查人员在此UM-HN孢子计划，NCI和其他孢子计划中的努力，全面的组织采购，加工，存储，头部和颈部癌细胞系库，分布提出了过程和数据管理系统。该核心代表基本的协作努力科学家，解剖学家，临床医生和数据经理。它建立了我们先前在收集方面的经验在我们的头部和颈部肿瘤学计划调查人员和我们UM癌症中心组织和肿瘤采购核心的经验，以及与 UM前列腺孢子。详细的分配规则和全血，血清，新鲜的标准化处理组织具有适当嵌入和冷冻存储的组织，RNA中的组织，石蜡包埋的组织，包括免疫组织学，组织微阵列和细胞培养准备。详细的描述性关系数据库，包括肿瘤特征，患者人口统计，健康行为，合并症，合并症，家族史，治疗和随访数据与肿瘤存储库数据和每个研究者的数据联系在一起实验室由安全的头和颈部基于Web的数据库，称为BioDBX，该数据库与临床连接 UM卫生系统数据存储库（CARE Web）。提供灵活性以满足任何项目的特定需求并纳入新技术，用于未来的项目或与外部研究人员合作。我们已经提出了一个模型系统，该系统将是一种最大化出色的组织临床数据可用性的资源为了研究整个NCI孢子社区的这些相对罕见的头颈癌。