WEIGHT LOSS & ASTHMA

减肥

• 批准号: 7959624
• 负责人: RICHARD E PRATLEY
• 金额: $ 32.39万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7959624
• 关键词: Adipose tissue; Asthma; Basic Science; Biology; Body Weight decreased; Bronchoalveolar Lavage; Bronchoscopy; Cell Separation; Computer Retrieval of Information on Scientific Projects Database; Endocrinologist; Epidemic; Epidemiology; Fatty acid glycerol esters; Funding; Grant; Health; In Vitro; Inflammation; Inflammatory; Institution; Lung; Measures; Morbid Obesity; Obesity; Operative Surgical Procedures; Patients; Physiological; Population; Research; Research Personnel; Resources; Respiratory physiology; Risk; Source; Surgeon; Techniques; Time; Translational Research; United States National Institutes of Health; Visceral; bariatric surgery; comparison group; improved; subcutaneous

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There is very strong evidence from epidemiological and basic science studies to suggest that obesity may increase the risk of asthma. This has very important implications for the health of the US population given the current parallel epidemics of obesity and asthma. Understanding the physiological and inflammatory changes induced by obesity would make an important contribution to our understanding of the relationship between obesity and asthma. It is also important to understand why some obese people develop asthma, but others do not. We hypothesize that obese people with asthma have altered adipose tissue related inflammation compared to obese people without asthma. We also hypothesize that weight loss will improve physiological and inflammatory measures of asthma We have assembled a multi-disciplinary team, including surgeons, endocrinologists and pulmonologists to study patients undergoing gastric bypass surgery for extreme obesity. We are studying obese patients with asthma before surgery and in the 12 months after surgery: we are studying (i) their lung function with sophisticated physiological techniques before and after surgery (ii) adipose-related inflammation by in vitro studies on visceral and subcutaneous fat collected at the time of surgery (iii) circulating pro-inflammatory factors produced by adipose tissue and (iv) inflammation in the lung by bronchoscopy with isolation of cells by bronchoalveolar lavage for in vitro studies. As a comparison group we are also studying obese patients without asthma to determine if there are differences in adipose tissue-related factors that could explain why they do not have asthma.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 流行病学和基础科学研究有非常有力的证据，以表明肥胖可能会增加哮喘的风险。 鉴于当前肥胖和哮喘的平行流行病，这对美国人口的健康具有非常重要的意义。 了解肥胖引起的生理和炎症变化将为我们理解肥胖与哮喘之间的关系做出重要贡献。也重要的是要了解为什么有些肥胖的人会哮喘，而另一些人则没有。 我们假设与没有哮喘的肥胖者相比，肥胖患者患有哮喘患者与脂肪组织相关的炎症改变了。 我们还假设体重减轻将改善哮喘的生理和炎症措施 我们组建了一个多学科团队，包括外科医生，内分泌学家和肺科医生，研究接受胃旁路手术的患者以进行极端肥胖。 我们正在研究手术前和手术后的12个月内肥胖患者：我们正在研究（i）手术前后的肺功能（ii）通过在手术和循环系统时（iii）循环症状（iii）循环促进（III）促进（III）的脂肪研究（ii）脂肪中与脂肪相关的炎症（II）与炎症相关（III）的炎症（III）。通过支气管镜检查，通过支气管肺泡灌洗分离细胞进行体外研究。 作为一个比较组，我们还正在研究没有哮喘的肥胖患者，以确定脂肪组织相关的因素是否存在差异，这些因素可以解释为什么他们没有哮喘。