What controls calcium homeostasis in human airway smooth muscle?

什么控制人气道平滑肌中的钙稳态？

• 批准号: G0701390/1
• 负责人: Ian Hall
• 金额: $ 41.81万
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0701390%2F1
• 关键词: What; controls; calcium; homeostasis; human

Asthma is a major cause of lost working days in the UK: currently, according to Asthma UK 5.2 million are taking asthma treatment. The majority of symptoms are caused by narrowing of the airways. A major component of airway narrowing is due to contraction of the muscle (called airway smooth muscle) in the airway wall. This contraction is due to calcium release within the muscle cell or entry of calcium into the muscle cell. The mechanisms underlying these responses are poorly understood. This project will systematically define the important pathways and signalling molecules responsible for these processes. By defining these mechanisms, it should be feasible to design new treatments for asthma. We will also gain a fuller understanding of the mechanisms underlying the development of asthma.

哮喘是英国工作日损失的主要原因：目前，根据英国哮喘，有520万人正在接受哮喘治疗。大多数症状是由气道变窄引起的。气道狭窄的一个主要组成部分是由于气道墙中肌肉（称为气道平滑肌）的收缩。这种收缩是由于肌肉细胞内的钙释放或钙进入肌肉细胞。这些反应的基础机制知之甚少。该项目将系统地定义负责这些过程的重要途径和信号分子。通过定义这些机制，设计哮喘的新疗法应该是可行的。我们还将对哮喘发育发展的机制有更深入的了解。