Defining the genetic contribution and functional role to altered lung function of genes identified by GWAS meta-analysis

定义 GWAS 荟萃分析确定的基因对改变肺功能的遗传贡献和功能作用

• 批准号: G1000861/1
• 负责人: Ian Hall
• 金额: $ 169万
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G1000861%2F1
• 关键词: Defining; genetic; contribution; functional; role

Chronic obstructive pulmonary disease (COPD) is a common cause of illness, occuring mostly in smokers, which results in worsening cough and breathlessness and which is responsible for 30,000 deaths per year in the UK. It is recognised that genetics plays a role in the development of COPD, and recently we have identified that genetic variants in three genes called glutathione S transferase CD (GSTCD), HTR4 and AGER are risk factors for the development of abnormal lung function and COPD. The aims of this programme of research are to find out the role of these genes in the lungs, to determine how genetic variability in these genes alters lung function, and to assess how different genetic variants contribute to the development of airways disease focusing initially on COPD.

慢性阻塞性肺疾病（COPD）是疾病的常见原因，主要发生在吸烟者中，这导致咳嗽和呼吸困难，并导致英国每年30,000人死亡。人们认识到遗传学在COPD的发展中起作用，最近我们确定，三种称为谷胱甘肽的转移酶CD（GSTCD），HTR4和AGER的遗传变异是肺功能异常和COPD的危险因素。该研究计划的目的是找出这些基因在肺中的作用，以确定这些基因的遗传变异性如何改变肺功能，并评估不同的遗传变异如何有助于最初关注COPD的气道疾病的发展。