Microchip-Based Perchlorate Analyzer for Water Remediation Monitoring and Field A

用于水体修复监测和现场 A 的微芯片高氯酸盐分析仪

• 批准号: 7923649
• 负责人: Dale M Willard
• 金额: $ 6.56万
• 依托单位: ADVANCED MICROLABS, LLC
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-25 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7923649
• 关键词: Address; Air Bags; Anions; Beds; Businesses; California; Chemistry; Colorado; Communities; Coupled; Detection; Development; Developmental Delay Disorders; Devices; Dyes; Engineering; Environment; Equipment; Event; Exposure to; Fertilizers; Flare; Funding; Generations; Government; Hour; Laboratories; Legal patent; Maintenance; Measurement; Measures; Medical; Membrane; Methods; Monitor; Operative Surgical Procedures; Paint; Particulate Matter; Perchlorates; Phase; Plant Resins; Power Sources; Prevalence; Procedures; Process; Pump; Resources; Running; Sampling; Series; Site; Small Business Technology Transfer Research; Solid; Source; Surface; System; Technology; Technology Transfer; Testing; Thyroid Function Tests; Time; Training; United States Environmental Protection Agency; Universities; Validation; Water; Work; base; cost; design; detector; drinking water; exposed human population; instrument; instrumentation; interest; micro-total analysis system; microchip; monitoring device; prototype; public health relevance; remediation; superfund site; voltage; water sampling; water sampling/testing

DESCRIPTION (provided by applicant): This Small Business Technology Transfer Phase I project will develop a prototype online perchlorate monitor for a resin bed perchlorate remediation reactor. The device will be have less than 4 ppb limit- of-detection, provide results in less than 3 min., and require only periodic microchip replacement as routine maintenance. Currently, perchlorate can only be detected below 10 ppb using laboratory based equipment requiring trained technicians and, most importantly, at least several hours of time, and therefore, impractical for online monitoring. The Henry Group at Colorado State University has recently demonstrated sub ppb perchlorate detection using a patent-pending lab-on-a-chip technology with results that include real water sample testing. This technology opens the door for online monitoring of perchlorate remediation operations, which will significantly reduce the costs. Entire resin beds costing $100k in materials and additional costs in disposal would no longer be needed. This Phase I proposal will: 1. Develop pumps, valves, instrumentation, etc. to assemble a field deployable device, 2. Optimize our microchip functions by incorporating a sample membrane barrier and assessing nonhazardous alternative internal standards, and 3. Method validation and field testing. PUBLIC HEALTH RELEVANCE: Human exposure to perchlorate is of concern because of the potential for impaired thyroid function, leading to a number of developmental delays and other medical problems. Its prevalence in the environment only gained interest in the late 1990's, once a method was developed for its detection at the 4 ppb level. In 2005 after being added to the Environmental Protection Agency's (EPA) Unregulated Contaminant Monitoring Rule (UCMR1) list, a sampling of 2800 large water systems and 800 smaller systems, representing less than 10% of all US water systems, revealed contamination in 153 sites over 25 states. As of 2005, 120 remediation projects were underway, including 15 superfund sites, costing hundred's of millions of dollars to fund, mostly coming from government coffers. Our online monitoring device will significantly reduce costs for remediation. In addition to lowering costs to existing remediation, it will also allow smaller communities address cleanup that would otherwise not have enough resources.

描述（由申请人提供）：该小型企业技术转让第一阶段项目将为树脂床高氯酸盐修复反应器开发在线高氯酸盐监测仪原型。该设备的检测限低于 4 ppb，在 3 分钟内提供结果，并且只需定期更换微芯片作为日常维护。目前，使用实验室设备只能检测低于 10 ppb 的高氯酸盐，需要经过培训的技术人员，最重要的是，至少需要几个小时的时间，因此对于在线监测来说是不切实际的。科罗拉多州立大学亨利集团最近展示了使用正在申请专利的芯片实验室技术进行亚 ppb 级高氯酸盐检测，其结果包括真实水样测试。该技术为高氯酸盐修复操作的在线监控打开了大门，这将显着降低成本。整个树脂床将不再需要花费 10 万美元的材料和额外的处理费用。该第一阶段提案将： 1. 开发泵、阀门、仪器等来组装现场可部署设备， 2. 通过合并样品膜屏障和评估无害替代内标来优化我们的微芯片功能，以及 3. 方法验证和现场测试。公众健康相关性：人类接触高氯酸盐值得关注，因为可能会损害甲状腺功能，从而导致许多发育迟缓和其他医疗问题。直到 20 世纪 90 年代末，当开发出一种可检测 4 ppb 水平的方法后，它在环境中的普遍存在才引起了人们的兴趣。 2005 年，在被添加到美国环境保护署 (EPA) 的不受管制污染物监测规则 (UCMR1) 清单后，对 2800 个大型供水系统和 800 个小型系统（占美国所有供水系统的不到 10%）进行了抽样调查，结果显示 153 个地点受到污染超过 25 个州。截至2005年，共有120个修复项目正在进行中，其中包括15个超级基金点，耗资数亿美元，大部分来自政府财政。我们的在线监测设备将显着降低修复成本。除了降低现有修复成本外，它还将使较小的社区能够解决原本没有足够资源的清理问题。