Blue Light and Melatonin for Treatment of Circadian Rhythm Disorders and Jet Lag

蓝光和褪黑激素治疗昼夜节律紊乱和时差反应

• 批准号: 7810704
• 负责人: CHARMANE I EASTMAN
• 金额: $ 31.4万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7810704
• 关键词: Adverse effects; Boxing; Circadian Dysregulation; Circadian Rhythms; Complement component C1s; Delayed Sleep Phase Syndrome; Destinations; Distress; Dose; Fatigue; Future; Goals; Health; Home environment; Hour; Human; Individual; Jet Lag Syndrome; Light; Measures; Melatonin; Monitor; Occupations; Pattern; Performance; Phase; Photoreceptors; Physiologic pulse; Protocols documentation; Questionnaires; Reading; Recommendation; Relative (related person); Retinal Ganglion Cells; Schedule; Schools; Sleep; Sleep Deprivation; Sleep Disorders; Strigiformes; Symptoms; System; Techniques; Testing; Time; Travel; Vertebrate Photoreceptors; Visual system structure; Work; Wrist; alertness; circadian pacemaker; computerized; gastrointestinal; novel; prevent; response; shift work; therapy design

There are many situations in which modern humans find that their circadian rhythms are not aligned with their desired sleep/wake schedule, such as after jet travel, during shift work, and in some sleep disorders such as the delayed sleep phase syndrome. This misalignment causes excessive fatigue, sleepiness, decrements in alertness, loss of concentration, impaired performance, shortened and disrupted sleep, gastrointestinal distress and eventually health problems. Bright light and melatonin have been used to help phase shift the human circadian clock, but little has been done to test the combination. Recent exciting discoveries show that the circadian system uses a novel photoreceptor (besides the rods and cones) which is most sensitive to short wavelength (blue) light, and that larger phase shifts can be produced with blue light than with other wavelengths. We will test the combination of blue-enriched light and melatonin in a protocol that is practical for everyday use at home and at work. In all studies, the sleep schedule will be gradually phase advanced, and in most studies a small dose of melatonin will be used in the afternoon and bright blue-enrichedlight (from a single light box) will be used in the morning to help phase advance circadian rhythms. Our overall goal is to produce the largest possible phase advance with the least effort, while keeping the circadian rhythms aligned with the sleep schedule to prevent side-effects orjet-lag-type symptoms. Specific Aim #1 is to determine whether blue-enriched light produces a larger phase advance than white light. Specific Aim #2 is to assess the relative contributions of afternoon melatonin and morning bright blue- enriched light to phase advances, and to determine whether there is any merit to a melatonin-only treatment that does not require a light box. Specific Aim #3 is to determine whether distributing the same total duration of bright blue-enriched light into different patterns, by changing the duration of the pulses and their number, can increase the phase advance. Specific Aim #4 is to determine whether the duration of bright light exposure can be reduced while stillproducing acceptable magnitudes of phase shin. In all studies, circadian phase will be assessed from complete melatonin profiles collected in dim light. We will also measure sleep (with wrist activity monitors and logs), sleepiness and other symptoms (questionnaires) and performance (computerized). These studies will yield practical recommendations for phase shifting the circadian clock and may also provide information about how the human circadian clock responds to light.

在许多情况下，现代人类发现他们的昼夜节律与 他们所需的睡眠/唤醒时间表，例如喷气式旅行后，在轮班工作中以及在某些睡眠障碍中 例如延迟的睡眠期综合征。这种未对准会导致过度疲劳，嗜睡， 警觉性降低，集中度丧失，性能受损，睡眠缩短和破坏， 胃肠道困扰和最终健康问题。明亮的光线和褪黑激素已被用来帮助 相位移动人类昼夜节律，但几乎没有完成测试组合。最近令人兴奋 发现表明，昼夜节律系统使用一种新型的光感受器（除了杆和锥体） 对短波长（蓝色）光最敏感，并且可以用蓝光产生较大的相移 而不是其他波长。 我们将在协议中测试富含蓝色的光和褪黑激素的组合，该协议是实用的 每天在家中和工作中使用。在所有研究中，睡眠时间表都将逐渐高级，并且 在大多数研究中 单灯箱）将在早晨使用，以帮助阶段推进昼夜节律。我们的总体目标是 在努力最少的同时，保持最大的阶段进步，同时保持昼夜节律对齐 借助睡眠时间表以防止副作用ORJET-LAG型症状。 特定目的＃1是确定富含蓝色的光比白色产生更大的阶段前进 光。特定目的＃2是评估午后褪黑激素和早晨明亮的蓝色的相对贡献 富含光到相位的光，并确定仅纯褪黑激素治疗是否有任何优点 这不需要灯箱。特定目标＃3是确定是否分配相同的总持续时间 通过更改脉冲的持续时间及其数量，富含蓝色的光线为不同的模式 可以增加阶段的进步。特定目的＃4是确定明亮光的持续时间是否 可以减少暴露，同时仍然产生相胫骨的可接受幅度。在所有研究中， 将从昏暗的光线收集的完整褪黑激素谱进行评估昼夜节律。我们也会 测量睡眠（手腕活动监测和原木），嗜睡和其他症状（问卷）和 性能（计算机化）。这些研究将产生相移的实用建议 昼夜节律时钟，还可能提供有关人类昼夜节律时钟如何响应光的信息。