Blue Light and Melatonin for Treatment of Circadian Rhythm Disorders and Jet Lag

蓝光和褪黑激素治疗昼夜节律紊乱和时差反应

基本信息

批准号：
7238735
负责人：
CHARMANE I EASTMAN
金额：
$ 32.33万
依托单位：
RUSH UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
起止时间：
2000-09-01 至 2011-03-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): There are many situations in which modern humans find that their circadian rhythms are not aligned with their desired sleep/wake schedule, such as after jet travel, during shift work, and in some sleep disorders such as the delayed sleep phase syndrome. This misalignment causes excessive fatigue, sleepiness, decrements in alertness, loss of concentration, impaired performance, shortened and disrupted sleep, gastrointestinal distress and eventually health problems. Bright light and melatonin have been used to help phase shift the human circadian clock, but little has been done to test the combination. Recent exciting discoveries show that the circadian system uses a novel photoreceptor (besides the rods and cones) which is most sensitive to short wavelength (blue) light, and that larger phase shifts can be produced with blue light than with other wavelengths. We will test the combination of blue-enriched light and melatonin in a protocol that is practical for everyday use at home and at work. In all studies, the sleep schedule will be gradually phase advanced, and in most studies a small dose of melatonin will be used in the afternoon and bright blue-enriched light (from a single light box) will be used in the morning to help phase advance circadian rhythms. Our overall goal is to produce the largest possible phase advance with the least effort, while keeping the circadian rhythms aligned with the sleep schedule to prevent side-effects or jet-lag-type symptoms. Specific Aim #1 is to determine whether blue-enriched light produces a larger phase advance than white light. Specific Aim #2 is to assess the relative contributions of afternoon melatonin and morning bright blue-enriched light to phase advances, and to determine whether there is any merit to a melatonin-only treatment that does not require a light box. Specific Aim #3 is to determine whether distributing the same total duration of bright blue-enriched light into different patterns, by changing the duration of the pulses and their number, can increase the phase advance. Specific Aim #4 is to determine whether the duration of bright light exposure can be reduced while still producing acceptable magnitudes of phase shift. In all studies, circadian phase will be assessed from complete melatonin profiles collected in dim light. We will also measure sleep (with wrist activity monitors and logs), sleepiness and other symptoms (questionnaires) and performance (computerized). These studies will yield practical recommendations for phase shifting the circadian clock and may also provide information about how the human circadian clock responds to light.

描述（由申请人提供）：在许多情况下，现代人类发现他们的昼夜节律与他们所需的睡眠/唤醒时间表不符，例如喷气式旅行后，轮班工作期间以及某些睡眠障碍，例如延迟的睡眠期综合征。这种未对准会导致过度疲劳，嗜睡，机敏性降低，集中度丧失，性能受损，睡眠缩短和破坏，胃肠道遇险以及最终的健康问题。明亮的光线和褪黑激素已被用来帮助相位移动人类昼夜节律的时钟，但是几乎没有做任何用于测试组合的方法。最近的令人兴奋的发现表明，昼夜节律系统使用了一种新型的感光器（除了杆和锥体），该光感受器对短波长（蓝色）光最敏感，并且比其他波长可以用蓝光产生更大的相移。我们将测试富含蓝色的光和褪黑激素与在家中和工作中日常使用的协议中的组合。在所有研究中，睡眠时间表都将逐渐高级，并且在大多数研究中，下午将使用一小剂量的褪黑激素，而明亮的蓝色富含光（来自一个灯箱）将在早晨使用，以帮助阶段提前循环节奏节奏。我们的总体目标是以最少的精力产生最大的阶段进步，同时保持昼夜节律与睡眠时间表保持一致，以防止副作用或喷气滞后型症状。特定目的＃1是确定富含蓝色的光比白光产生更大的相位前进。具体目的＃2是评估午后褪黑激素和鲜蓝色富含光对相位进步的相对贡献，并确定不需要褪黑激素的治疗是否需要任何不需要轻盒的方法。特定目的＃3是确定通过改变脉冲持续时间及其数量来增加相同的富含蓝色的光的总持续时间是否可以增加相位的前进。特定目的＃4是确定是否可以减少明亮光的持续时间，同时仍会产生可接受的相位移位幅度。在所有研究中，昼夜节相都将根据以昏暗的光收集的完整褪黑激素谱进行评估。我们还将测量睡眠（手腕活动监测器和日志），嗜睡和其他症状（问卷）和性能（计算机化）。这些研究将对循环循环时钟产生实用的建议，并可能提供有关人类昼夜节律如何对光的响应的信息。