CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCH

CTSA 儿科研究基础设施

• 批准号: 8173838
• 负责人: THOMAS Arthur PEARSON
• 金额: $ 57.69万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173838
• 关键词: Pediatric Research; Research Infrastructure; Pediatric Research; Research Infrastructure

This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. The University of Rochester Clinical and Translational Science Institute (UR CTSI) will be created as the academic home for clinical and translational science, providing a centralized, integrated infrastructure. Under a system of governance in which the UR CTSI Program Director has authority over space, faculty, budgets, and other resources related to the CTSI, and in which much of the current GCRC budget is distributed to CTSI Key Functions in support of these functions, we plan to transform the two distinct research fields of clinical and translational science into a single new discipline. The goals of this discipline nclude the creation of new knowledge and techniques to diagnose, prevent and treat human disease, and he establishment of an environment that catalyzes their application to clinical practice in the community. To achieve these goals, we propose specific aims involving: novel methodologies; pilot studies; upgraded biomedical informatics, epidemiology, research design, ethics, and regulatory support; community engagement; new technology and resource cores; new educational and training programs; an Upstate New York Consortium; and rigorous evaluation and measurement of performance outcomes. Strategic planning for the UR CTSI has been underway for several years prior to this RFA. Evidence of institutional support includes commitment to a new 150,000 sq. ft. Clinical and Translational Science Building (CTSB) in which faculty conducting clinical and translational research will be brought together with students and trainees in existing and new degree-granting programs, with supporting regulatory and administrative functions, and with faculty working in collaborative disciplines such as biostatistics, epidemiology, and biomedical nformatics. The Director and Co-Directors of the UR CTSI will integrate the clinical and translational science functions contained in the CTSB with those functions located at other campus locations, such as functional genomics, other translational resources, and the General Clinical Research Center (GCRC). As an integral part of the CTSI, the GCRC will move into a newly-renovated 10,500 sq ft facility across the street from the CTSB, with enhanced functionality and subject access. As well, the UR CTSI will create two-way synergies with local community groups (school system, faith community, business, foundations) and with other Upstate New York institutions. Further, the UR CTSI will enable the sharing of data across disciplines and across institutions while assuring the privacy and confidentiality of human subjects. In summary, by coalescing and integrating new facilities with enhanced infrastructure, community and state-wide partnerships, a strong foundation of existing research and training, and a fundamentally reorganized administrative structure, the CTSI will transform the conduct of clinical and translational science at UR and contribute nationally to the forging of this new discipline.

该子项目代表CTSA资金百分比的估计值 被用于广泛的研究领域（艾滋病研究，儿科研究或 临床试验）。 列出的总成本只是CTSA数量的估计值 基础设施朝向这一研究领域，而不是直接提供的资金 NCRR授予subproject或subproject人员。 罗切斯特大学的临床与转化科学研究所（UR CTSI）将被创建为临床和转化科学的学术家园，提供集中综合的基础设施。 在一个治理体系下，UR CTSI计划主管对与CTSI有关的太空，教职员工，预算和其他资源具有权力 分布在CTSI关键功能中以支持这些功能，我们计划将两个不同的临床和转化科学研究领域转变为单个新学科。这项学科的目标是创建新知识和技术来诊断，预防和治疗人类疾病，并建立了一种促进其在社区中临床实践中应用的环境。为了实现这些目标，我们提出了涉及的特定目标：新方法；试点研究；升级的生物医学信息学，流行病学，研究设计，伦理和监管支持；社区参与；新技术和资源核心；新的教育和培训计划；北部新的 约克财团；以及对绩效结果的严格评估和测量。在此RFA之前，UR CTSI的战略规划已经进行了几年。机构支持的证据包括对新的150,000平方英尺的临床和转化科学大楼（CTSB）的承诺，其中 进行临床和转化研究的教师将与现有和新学位授予计划的学生和受训者一起，并支持监管和行政职能，并在合作学科中工作，例如生物统计学，流行病学和生物医学学学科 Nformatics。 UR CTSI的主任和联合指导者将将CTSB中包含的临床和转化科学功能与位于其他校园位置的功能（例如功能基因组学，其他转化资源和一般临床研究中心（GCRC））相结合。作为一个积分 CTSI的一部分，GCRC将进入CTSB的街道上新近装修的10,500平方英尺的设施，并具有增强的功能和主题访问。同样，UR CTSI将与当地社区团体（学校系统，信仰社区，商业，基金会）以及其他上州建立双向协同作用 纽约机构。此外，UR CTSI将在确保人类受试者的隐私和机密性的同时，使跨学科和机构之间的数据共享。总而言之，通过将新设施与增强的基础设施，社区和全州范围的伙伴关系结合在一起，这是一个强大的 CTSI的基础是现有的研究和培训，以及从根本上重组的行政结构，将改变UR的临床和转化科学的行为，并在全国范围内为这项新学科的锻造做出贡献。