TRANSFORMING CLINICAL AND TRANSLATIONAL RESEARCH AND EDUCATION AT ROCKEFELLER

改变洛克菲勒的临床和转化研究与教育

• 批准号: 8173835
• 负责人: Barry Coller
• 金额: $ 207.29万
• 依托单位: ROCKEFELLER UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173835
• 关键词: Clinical; Education; Translational Research

This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. The Rockefeller University Hospital, a GCRC awardee since 1963, has been the continuous "home" for clinical and translational science at Rockefeller since 1910. It has been the site of numerous landmark scientific and clinical contributions, and many of its trainees have gone on to become academic leaders. With the new resources available under a Clinical and Translational Science Award (CTSA), a core faculty of. distinguished investigators, whose research spans the basic-translational spectrum and encompasses a broad range of scientific and medical disciplines, will integrate and expand their scientific and educational programs in a new Rockefeller University Center for Clinical and Translational Science. The new Center will transform clinical and translational research by encouraging new studies, and by enhancing and centralizing the support structures required to conduct studies with scientific rigor and an absolute commitment to protection of human subjects and participant safety. The key elements in the transformation will be: 1) A new governance structure reflecting the NIH cooperative agreement (U54) "assistance" mechanism, 2) Creation of a new K-12 Clinical Research Scholars Program offering Masters and PhD level degrees to complement the current Clinical Scholars,Program, 3) Infrastructure enhancements to facilitate the development and conduct of clinical protocols under the principle of Good Clinical Practice (GCP), including biomedical informatics, biostatistics. bionutrition, research nursing, research pharmacy, participant recruitment and community engagement, and regulatory support and oversight from the clinical research (research subject advocate) support office, 4) Development of innovative and novel core methodologies related to dendritic cell therapy; hepatitis C, and malignancies; genetics/genomics; assessing the immune response; and metabolic phenotyping. The Center will continue Rockefeller's tradition of focusing on the interface between scientific discovery, human pathophysiology, and novel diagnostic, preventive and therapeutic strategies. It will partner with industry, when mutually beneficial, to achieve these goals. The Center will also be an active member of the National CTSA Consortium, offering the Consortium novel ideas and tools for conducting and evaluating clinical and translational research. It will also eagerly adopt the best practices identified by the Consortium and adhere to the standards set by the Consortium.

该子项目代表CTSA资金百分比的估计值 被用于广泛的研究领域（艾滋病研究，儿科研究或 临床试验）。 列出的总成本只是CTSA数量的估计值 基础设施朝向这一研究领域，而不是直接提供的资金 NCRR授予subproject或subproject人员。 自1963年以来，洛克菲勒大学医院（Rockefeller University Hospital）是GCRC奖项，自1910年以来一直是洛克菲勒（Rockefeller）临床和转化科学的“家”。它一直是众多具有里程碑意义的科学和临床贡献的地点，许多受训者已经继续成为学术领导者。和 根据临床和转化科学奖（CTSA）获得的新资源，这是一个核心教师。 杰出的研究人员的研究涵盖了基本的翻译光谱，并涵盖了广泛的科学和医学学科，它将整合和扩展其科学和教育 新洛克菲勒大学临床与转化科学中心的计划。新中心将通过鼓励新的研究，并加强和集中以科学严谨的研究所需的支持结构来改变临床和转化研究 保护人类受试者和参与者的安全。转型的关键要素将是：1）一种新的治理结构，反映了NIH合作协议（U54）“援助”机制，2）创建新的K-12临床研究学者计划，以提供硕士学位和博士水平来补充硕士学位 当前的临床学者，计划，3）基础设施增强功能，以促进良好临床实践原则（GCP）（包括生物医学信息学，生物统计学），促进临床方案的发展和行为。 Bionutrition，研究护理，研究药房，参与者招聘和社区参与以及临床研究的监管支持和监督（研究主题 倡导者）支持办公室，4）开发与树突状细胞疗法有关的创新和新颖的核心方法；丙型肝炎和恶性肿瘤；遗传学/基因组学；评估免疫反应；和代谢表型。该中心将继续洛克菲勒的关注传统 科学发现，人类病理生理学以及新颖的诊断，预防和治疗策略之间的界面。在互惠互利的情况下，它将与行业合作，以实现这些目标。该中心还将是国家CTSA财团的活跃成员 以及进行和评估临床和转化研究的工具。它还将急切地采用财团确定的最佳实践，并遵守财团设定的标准。