Development of Instrumentation for High-Rate Production of Hyperpolarized 3He Gas

超极化 3He 气体高速生产仪器的开发

基本信息

批准号：
7257512
负责人：
RONALD L WALSWORTH
金额：
$ 24.17万
依托单位：
HARVARD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-03-01 至 2009-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7257512
关键词：
Aluminum Alveolar Amplifiers Biomedical Engineering Biomedical Research Breathing Cells Characteristics Clinical Clinical Research Complex Computers Condition Coupled Development Devices Diagnostic Diffusion Dimensions Electronics Environment Environmental air flow Equipment European Funding Funding Mechanisms Gases Glass Guidelines Helium Hospitals Hour Human Image Imaging Techniques In Situ Institutes Internet Laboratories Lasers Life Light Lung Lung diseases Magnetic Resonance Imaging Magnetism Maps Medicine Methods Nature Noble Gases Nuclear Numbers Operating System Operative Surgical Procedures Optics Perfusion Physicians Physics Physiological Physiology Process Production Pump Purpose Qualifying Rate Relaxation Research Resolution Rubidium Sampling Science Signal Transduction Stainless Steel Structure System Techniques Technology Teflon Testing Time United States National Institutes of Health Vacuum Variant Work analog base bioimaging cost design gas analyzer instrument instrumentation interest laptop lung imaging magnetic field multidisciplinary novel physical science polarimetry polyfunctional aziridine pressure programs prototype technology development

项目摘要

DESCRIPTION (provided by applicant): The broad objective of this proposal is to develop a novel, rapid, robust and portable 3He hyperpolarization apparatus that will produce ~ 1 L / hour of 3He gas spin-polarized to 40% or greater. The apparatus will use the metastability-exchange optical pumping method (MEOP), a theoretically-favorable process that has traditionally been difficult to implement. Recent advances in compressor and laser technology have overcome these hurdles. A polarizer based on the MEOP process will provide an almost ten-fold increase in production rate for hyperpolarized 3He when compared to current polarizer technology based on the alternative spinexchange optical-pumping method (SEOP). The proposed apparatus will be the first MEOP 3He hyperpolarization apparatus dedicated to biomedical MRI use in the US and which can be located in the biomedical imaging environment. This multidisciplinary program bridges the physical and biomedical sciences, with the potential to provide significant breakthrough research in pulmonary physiology and medicine. Thus this program qualifies for the R-21 funding mechanism. The Specific Aims of the program are: 1. Design and fabricate a prototype 3He hyperpolarization apparatus that operates using the metastabilityexchange optical pumping (MEOP) method, and produces ~ 1 L per hour of 40% polarized 3He gas. 2. Determine optimum operating conditions for the apparatus, studying 3He polarization signal as a function of operating parameters, including gas mixture, pressure, and compression rate. 3. Perform phantom 3He MRI studies with gas from the MEOP 3He hyperpolarization apparatus.

描述（由申请人提供）：本提案的主要目标是开发一种新颖、快速、坚固且便携式的 3He 超极化装置，该装置将产生约 1 L/小时的 3He 气体，自旋极化达到 40% 或更高。该设备将使用亚稳态交换光泵浦方法（MEOP），这是一种理论上有利的过程，但传统上很难实现。压缩机和激光技术的最新进展克服了这些障碍。与当前基于替代脊柱交换光泵浦方法 (SEOP) 的偏振器技术相比，基于 MEOP 工艺的偏振器将使超偏振 3He 的生产率提高近十倍。所提出的设备将是美国第一台专门用于生物医学 MRI 的 MEOP 3He 超极化设备，并且可以放置在生物医学成像环境中。这个多学科项目连接了物理和生物医学科学，有可能在肺生理学和医学方面提供重大突破性研究。因此，该计划符合 R-21 资助机制的资格。该计划的具体目标是： 1. 设计和制造原型 3He 超极化装置，该装置使用亚稳态交换光泵浦 (MEOP) 方法运行，每小时产生约 1 L 的 40% 极化 3He 气体。 2. 确定设备的最佳操作条件，研究 3He 极化信号作为操作参数（包括气体混合物、压力和压缩率）的函数。 3. 使用来自 MEOP 3He 超极化装置的气体进行模型 3He MRI 研究。