Next generation MEMS-VCSEL technology for ultra-low-cost dental and periodontal swept source optical coherence tomography imaging

用于超低成本牙科和牙周扫频光学相干断层扫描成像的下一代 MEMS-VCSEL 技术

• 批准号: 10481677
• 负责人: Vijaysekhar Jayaraman
• 金额: $ 27.5万
• 依托单位: PRAEVIUM RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-16 至 2023-09-13
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10481677
• 关键词: 3-Dimensional; Agreement; Amplifiers; Angiography; Appearance; Butterflies; Calculi; Caliber; Cardiology; Clinical; Clinical Research; Collaborations; Computer-Aided Design; Data; Dental; Dental Technology; Dentistry; Dermatology; Detection; Development; Devices; Diagnostic Imaging; Discipline; Fiber; Foundations; Frequencies; Funding; Generations; Gingiva; Goals; Grant; Hemorrhage; Image; Imaging Device; Imaging Phantoms; Imaging technology; Inflammation; Label; Lasers; Maintenance; Malignant Neoplasms; Measurement; Medical; Methods; Monitor; Nature; Ophthalmology; Optical Coherence Tomography; Optics; Oral cavity; Oral health; Output; Pain; Penetration; Performance; Periodontal Diseases; Periodontal Pocket; Phase; Price; Procedures; Prognosis; Public Health; Pump; Reporting; Research; Resolution; Scanning; Semiconductors; Site; Small Business Innovation Research Grant; Source; Speed; Surface; System; Technology; Testing; Thick; Time; Tissues; Translating; Universities; Validation; Visualization; Washington; Water; Work; absorption; alveolar bone; arm; base; bone quality; cancer imaging; clinical practice; commercialization; cost; density; design; dynamic system; flexibility; high resolution imaging; human imaging; human subject; imaging science; improved; indexing; invention; miniaturize; next generation; operation; programs; quantitative imaging; regenerative; research in practice; success; tool; waveguide

This proposal aims to enable a new generation of high-speed, low-cost, wavelength-flexible swept source optical coherence tomography (SS-OCT) imaging device technology targeting applications in dental imaging and based on microelectromechanical systems vertical cavity surface emitting lasers (MEMS-VCSELs) and planar lightwave circuits (PLCs). MEMS-VCSELs provide an unmatched combination of high and variable axial scan rate, dynamic single mode operation enabling long imaging range, and the potential for low-cost volume manufacturing through wafer scale fabrication and testing. The proposed effort involves a collaboration between Praevium Research, which pioneered MEMS-VCSELs for SS-OCT, and the University of Washington (UW), a world leader in SS-OCT structural and angiographic imaging in dentistry. This work seeks both to advance dental imaging science through new imaging tools and promote commercialization in cost-sensitive dental markets. Praevium Research will develop new high axial scan rate MEMS-VCSEL swept sources near water absorption minima at 1700nm and 2200nm, to enable longer imaging range due to reduced scattering at longer wavelengths. Imaging at these wavelengths may be particularly important in improving the ability of OCT to noninvasively determine periodontal pocket depth. In addition, Praevium will combine emerging electrically pumped MEMS-eVCSELs at 1310nm with advanced PLC technology, replacing bulky and environmentally sensitive fiber networks commonly employed in SS-OCT by lithographically defined waveguide devices. This will allow a radically miniaturized low-cost and stable SS-OCT subsystem with MEMS-VCSEL, optical amplifier, wavelength monitoring, and MZI interferometers on a single chip in a compact butterfly package, overcoming long-standing cost barriers to SS-OCT in dentistry. UW collaborators will use various generations of high axial scan rate MEMS-VCSELs, starting at 1310nm and migrating to 1700nm and 2200nm as these latter sources are developed, to develop real-time wide field of view (FOV) whole mouth structural (OCT) and label-free angiographic (OCTA) periodontal imaging. Current methods for assessing periodontal disease rely on invasive probing, induce unnecessary pain and bleeding, and are error-prone due to inconsistent frequency and force of probing and due to the complexity of gingival thickness and appearance. The proposed SS-OCT technology, by contrast, has the potential to create qualitative and quantitative imaging of microstructure and vasculature in gingival tissue. This will enable a comprehensive periodontal imaging diagnostic suite which can assess periodontal attachment, alveolar bone quality and level, gingival inflammation, sub gingival calculus plaque and tissue biotype. Such a system can also provide an objective means to determine and evaluate the prognosis of periodontal, regenerative and restorative therapies, improve computer-aided design and machining (CAD/CAM) for dental restorative procedures and planning, and become a reliable tool for long term monitoring and maintenance in clinical practice for oral health.

该提案旨在实现新一代高速、低成本、波长灵活的扫频光源 光学相干断层扫描 (SS-OCT) 成像设备技术，瞄准牙科成像和 基于微机电系统垂直腔表面发射激光器 (MEMS-VCSEL) 和平面 光波电路（PLC）。 MEMS-VCSEL 提供无与伦比的高可变轴向扫描组合 速率、动态单模式操作可实现长成像范围以及低成本批量的潜力 通过晶圆级制造和测试进行制造。拟议的工作涉及以下人员之间的合作： Praevium Research 是 SS-OCT 的 MEMS-VCSEL 的先驱，华盛顿大学 (UW) 是一家 牙科 SS-OCT 结构和血管造影成像领域的世界领先者。这项工作旨在推进牙科 通过新的成像工具进行成像科学，并促进成本敏感的牙科市场的商业化。 Praevium Research 将开发新型高轴向扫描速率 MEMS-VCSEL 近水扫频源 1700nm 和 2200nm 处的吸收最小值，由于在更长的时间内减少了散射，从而实现了更长的成像范围 波长。这些波长下的成像对于提高 OCT 的能力可能特别重要 无创地确定牙周袋深度。此外，Praevium 将结合新兴的电气 采用先进的 PLC 技术在 1310nm 泵浦 MEMS-eVCSEL，取代了笨重且环保的产品 敏感光纤网络通常通过光刻定义的波导设备应用于 SS-OCT。这 将实现彻底小型化、低成本且稳定的 SS-OCT 子系统，配备 MEMS-VCSEL、光学放大器、 波长监测和 MZI 干涉仪位于紧凑蝶形封装中的单个芯片上，克服了 牙科领域 SS-OCT 长期存在的成本障碍。 华盛顿大学合作者将使用各代高轴向扫描速率 MEMS-VCSEL，从 1310nm 开始 随着这些光源的开发，迁移到 1700nm 和 2200nm，以开发实时宽领域 视图 (FOV) 全口结构 (OCT) 和无标记血管造影 (OCTA) 牙周成像。当前的 评估牙周病的方法依赖于侵入性探测，会引起不必要的疼痛和出血，并且 由于探测频率和力度不一致以及牙龈厚度的复杂性，容易出错 和外观。相比之下，所提出的 SS-OCT 技术有潜力创造定性和 牙龈组织微观结构和脉管系统的定量成像。这将使全面 牙周成像诊断套件，可评估牙周附着、牙槽骨质量和水平， 牙龈炎症、龈下牙石斑块和组织生物型。这样的系统还可以提供 确定和评估牙周、再生和修复治疗预后的客观手段， 改进牙科修复程序和规划的计算机辅助设计和加工 (CAD/CAM)，以及 成为口腔健康临床实践中长期监测和维护的可靠工具。