Dana-Farber/Harvard SPORE in Breast Cancer

达纳法伯/哈佛孢子在乳腺癌中的应用

• 批准号: 7676025
• 负责人: ERIC P WINER
• 金额: $ 217.95万
• 依托单位: DANA-FARBER CANCER INST
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7676025
• 关键词: Dana; Farber; Harvard; SPORE; Breast

DESCRIPTION (provided by applicant): This application is for the first renewal of the Dana-Farber/Harvard SPORE in Breast Cancer, funded October 1, 2000. This SPORE is a component of the Breast Cancer Program in the Dana-Farber/Harvard Comprehensive Cancer Center (DF/HCC), and includes investigators from all major DF/HCC sites, Harvard University and MIT. Six Projects are proposed: Project 1 seeks common molecular pathways shared by basal-like and BRCA1 -linked cancers, and proposes a preoperative clinical trial in HER2-and ER-negative cancers. Project 2 will improve the treatment of HER2-positive cancer by searching for new targets and new drugs to use in combination with trastuzumab. Project 3 examines the response of ER-positive cancers to aromatase inhibitors, focusing on the role of coactivators and receptor occupancy of ER target sequences. Project 4 addresses the conundrum of metastasis using genomic approaches to study human primary and metastatic disease. Project 5 examines the role of tumor - stromal interactions in the early breast neoplasia, and seeks diagnostic and therapeutic targets that are active in this interaction. Project 6 will combine functional studies in cells and tissues with population-based research to seek alleles of kinase genes associated with increased risk. These Projects will be supported by the following Core Resources: Tissue and Pathology, providing a range of tissues and services; Clinical Studies, managing the interface between research and patients (recruitment, consent, and registration); Cohort Studies, managing and maintaining databases of research and clinical resources; Biostatistics, providing statistical consultation to SPORE investigators; and Bioinformatics to manage large genomic data sets and provide initial consultation to investigators seeking analytical help. The Harvard SPORE will devote 13% of its direct research costs to Career Development and Developmental Projects, and proposes selection and evaluation processes. The Communication, Planning and Administration Core will continually improve the SPORE by evaluating, planning and modifying our research to maximize our impact on breast cancer.

描述（由申请人提供）： 该应用是用于2000年10月1日资助的Dana-Farber/Harvard孢子的第一次续签。该孢子是Dana-Farber/Harvard综合癌症中心（DF/HCC）的乳腺癌计划的组成部分，包括来自所有主要DF/HCC站点，哈佛大学和MIT的所有主要DF/HCC站点。提出了六个项目：项目1寻求通过基底和BRCA1连接的癌症共享的常见分子途径，并在HER2和ER-ER阴性癌症中提出了术前临床试验。项目2将通过寻找与曲妥珠单抗结合使用的新靶标和新药物来改善HER2阳性癌症的治疗方法。项目3研究了ER阳性癌症对芳香酶抑制剂的反应，重点是共激活因子和ER靶序列的受体占用率。项目4使用基因组方法研究人类原发性和转移性疾病的基因组方法解决了转移的难题。项目5研究了早期乳腺肿瘤中肿瘤 - 基质相互作用的作用，并寻求这种相互作用中活性的诊断和治疗靶标。项目6将在细胞和组织中的功能研究与基于人群的研究相结合，以寻求与风险增加有关的激酶基因的等位基因。这些项目将得到以下核心资源的支持：组织和病理，提供一系列组织和服务；临床研究，管理研究与患者之间的接口（招募，同意和注册）；队列研究，管理和维护研究和临床资源的数据库；生物统计学，向孢子研究人员提供统计咨询；和生物信息学以管理大型基因组数据集并向寻求分析帮助的研究人员提供初步咨询。哈佛孢子将其直接研究成本的13％用于职业发展和发展项目，并提出选择和评估过程。沟通，计划和管理核心将通过评估，计划和修改我们的研究以最大程度地影响我们对乳腺癌的影响，从而不断改善孢子。