Phenomenology of Obsessive Compulsive Personality Disorder

强迫性人格障碍的现象学

• 批准号: 7895561
• 负责人: Anthony Pinto
• 金额: $ 18.52万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-08 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7895561
• 关键词: Address; Affect; Anorexia Nervosa; Anxiety; Area; Attention; Back; Behavior; Classification; Clinical; Clinical Trials; Cognitive; Cognitive remediation; Communities; Data; Decision Making; Development; Diagnosis; Diagnostic; Dimensions; Disease; Doctor of Philosophy; Evidence based treatment; Family; Five-Year Plans; Funding; Future; Goals; Grant; Heterogeneity; Hybrids; Individual; Intervention; Interview; Knowledge; Lead; Link; Manuscripts; Measures; Mental Depression; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Methodology; Modeling; Muscle Rigidity; Nature; Neurocognition; Neurocognitive; Neuropsychology; Obsessive-Compulsive Disorder; Obsessive-Compulsive Personality; Outcome Measure; Pathology; Patients; Personality; Personality Disorders; Personality Traits; Public Health; Quality of life; Research; Research Ethics; Research Personnel; Research Project Grants; Sampling; Severities; Structure; Symptoms; Testing; Time; Training Activity; Writing; career; career development; design; executive function; functional disability; improved; instrument; neurocognitive test; neuropsychological; novel; novel therapeutics; patient oriented research; programs; psychosocial; public health relevance; response; skills; success; trait; treatment trial

DESCRIPTION (provided by applicant): The proposed Mentored Patient-Oriented Research Career Development Award (K23) is a five-year plan that will enable the candidate to develop his career as a clinical researcher with a programmatic line of research in the area of obsessive compulsive personality disorder (OCPD). The application integrates formal coursework, complementary mentorship under established researchers, and an independent research program that will enable the candidate to: (1) develop expertise in the phenomenology of OCPD and personality disorder assessment; (2) become proficient in the neuropsychological assessment of executive functioning; (3) increase his knowledge of clinical trial methodology/research ethics so that he can examine novel therapeutics for OCPD; and (4) enhance his manuscript- and grant-writing skills in order to establish an independently-funded OCPD research program. In addition to mentored training activities, the candidate also proposes three research projects, each designed to advance the study of OCPD by filling specific gaps in our understanding of the disorder. In Project 1, the candidate will systematically examine the phenomenology of OCPD, particularly its core dimensions, psychosocial functioning (from both the patient and family perspective), and the controversial relationship with obsessive compulsive disorder (OCD). The candidate will develop much needed clinical instruments for the disorder, including a checklist of OCPD traits and symptomatic behaviors for characterization and a semi-structured interview to assess severity, both of which will facilitate further research. Project 2 will be the first comprehensive study of hypothesized executive deficits in OCPD (versus controls), namely cognitive inflexibility and overattention to details, using neurocognitive tests of set-shifting, response inhibition, decision making, and planning. To clarify the convergence of OCPD and OCD, the clinical and neurocognitive measures will be administered to OCPD subjects with and without comorbid OCD. Project 3 will test whether a novel intervention, cognitive remediation therapy, with demonstrated success in anorexia nervosa and OCD, leads to improvement in OCPD severity, as well as executive and psychosocial functioning. Public Health Relevance: OCPD is an impairing yet poorly understood personality disorder. Even though it is one of the most frequently diagnosed personality disorders across community and clinical samples, OCPD has received little empirical attention in the last two decades and there are currently no evidence-based treatments for the disorder. The proposed research is expected to have substantial clinical and public health significance because it will provide the necessary groundwork in phenomenology, assessment, and neurocognition to develop new treatments. In addition, the neurocognitive data will offer a first step in understanding potential underlying mechanisms, and the open trial will provide the first test of a novel intervention in this patient group.

描述（由申请人提供）：拟议的指导的面向患者的研究职业发展奖（K23）是一项为期五年的计划，将使候选人能够在强迫性强迫性人格障碍（OCPD）领域具有程序化研究领域的临床研究人员的职业。该应用程序将正式的课程工作，既定研究人员的互补指导制度以及一个独立的研究计划整合，该计划将使候选人能够：（1）开发OCPD现象学和人格障碍评估的专业知识； （2）精通执行功能的神经心理学评估； （3）提高他对临床试验方法/研究伦理的了解，以便他可以检查OCPD的新型治疗剂； （4）增强他的手稿和赠款书写技能，以建立独立资助的OCPD研究计划。除了指导的培训活动外，候选人还提出了三个研究项目，每个研究项目旨在通过填补我们对疾病的特定空白来推动OCPD的研究。在项目1中，候选人将系统地检查OCPD的现象学，尤其是其核心维度，社会心理功能（从患者和家庭的角度来看）以及与强迫症（OCD）的有争议的关系。候选人将为该疾病开发急需的临床工具，包括OCPD特征的清单和表征性的症状行为和半结构化访谈以评估严重性，这两者都将促进进一步的研究。项目2将是对OCPD的假设执行缺陷（与对照组）的首次全面研究，即认知僵化性和对细节的过度关注，并使用设置转换，响应抑制，决策和计划的神经认知测试。为了阐明OCPD和OCD的收敛性，将对有或没有合并症OCD的OCPD受试者进行临床和神经认知措施。项目3将测试新的干预措施，认知补救疗法是否在神经性厌食症和强迫症中取得成功，导致OCPD严重程度以及执行和社会心理功能的改善。公共卫生相关性：OCPD是一种受损但知之甚少的人格障碍。尽管它是社区和临床样本中最常见的人格障碍之一，但OCPD在过去的二十年中几乎没有得到经验的关注，目前尚无对该疾病的循证治疗。拟议的研究预计将具有实质性的临床和公共卫生意义，因为它将为现象学，评估和神经认知提供必要的基础，以开发新的治疗方法。此外，神经认知数据将为理解潜在的潜在机制提供第一步，开放试验将对该患者组进行新的干预措施进行首次测试。