Intensive Exercise to Improve Mitochondrial Dysfunction in Pediatric Obesity

强化运动可改善儿童肥胖症的线粒体功能障碍

• 批准号: 7707756
• 负责人: Amy Debra Fleischman
• 金额: $ 5.26万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7707756
• 关键词: Adult; Age-Years; Animals; Area; Body Composition; Cessation of life; Child; Childhood; Clinical Data; Cohort Studies; Complications of Diabetes Mellitus; Data; Detection; Development; Diabetes Mellitus; Diagnosis; Dual-Energy X-Ray Absorptiometry; Epidemic; Evaluation; Exercise; Fatty acid glycerol esters; First Degree Relative; Functional disorder; Future; Hormones; Human; Image; Imaging Techniques; Individual; Insulin; Insulin Resistance; Intervention; Intervention Trial; Investigation; Knowledge; Label; Life Style; Link; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Measures; Metabolic; Methods; Mitochondria; Molecular; Molecular Target; Non obese; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Pilot Projects; Population; Preparation; Prevalence; Prevention; Protocols documentation; Puberty; Randomized; Randomized Controlled Trials; Relative (related person); Risk; Role; Series; Staging; Technology; Testing; Time; United States; Work; base; design; diabetic patient; disorder risk; emerging adult; glucose metabolism; high risk; impaired glucose tolerance; improved; in vivo; mitochondrial dysfunction; novel; peripheral blood; prepuberty; programs; therapeutic target; young adult

DESCRIPTION (provided by applicant): Obesity and type 2 diabetes are occurring at epidemic rates in the United States and worldwide. The global burden of diabetes is estimated to double over the next 25 years. Obese children are at risk for the development of insulin resistance, relative insulin deficiency and type 2 diabetes mellitus. The prevention of type 2 DM is hindered by the lack of a non-invasive predictive test, knowledge as to individual risk and effective preventative measures. There is increasing evidence that alterations in mitochondria contribute to the development of diabetes in humans. Therefore, it is important to explore mitochondrial dysfunction as a potential predictor of diabetes in children and a potential target for prevention. The aims of the proposed protocol are to determine whether an intensive exercise intervention can improve mitochondrial function in children identified as having mitochondrial dysfunction and insulin resistance. The use of a non-invasive imaging technique will allow for a functional in vivo assessment of mitochondrial activity. We propose the investigation of an intensive exercise protocol designed to improve mitochondrial function in children who are insulin resistant and have documented mitochodrial dysfunction by magnetic resonance spectroscopy. The study is designed to investigate the plasticity of abnormal mitochondrial function in high risk children. In summary, the proposed projects will investigate mitochondrial function as a non-invasive predictive marker for the development of insulin resistance and type 2 diabetes mellitus in children and attempt to modify mitochondrial function with an intensive exercise intervention. The study of mitochondrial dysfunction in children may both identify those at risk for disease and provide a molecular therapeutic target for prevention and treatment.

描述（由申请人提供）： 肥胖和2型糖尿病是在美国和全球范围内以流行病的出现。在未来25年中，糖尿病的全球负担估计是一倍。肥胖儿童有胰岛素抵抗，相对胰岛素缺乏和2型糖尿病的风险。缺乏非侵入性预测测试，个人风险和有效的预防措施的知识，阻碍了2型DM的预防。越来越多的证据表明，线粒体的改变有助于人类糖尿病的发展。因此，重要的是要探索线粒体功能障碍，作为儿童糖尿病的潜在预测因子，并且是预防的潜在靶标。该方案的目的是确定强化运动干预是否可以改善被确定具有线粒体功能障碍和胰岛素抵抗的儿童的线粒体功能。使用非侵入性成像技术将允许对线粒体活性进行功能性评估。我们提出了一项强化运动方案的研究，旨在改善耐胰岛素耐药性并通过磁共振光谱记录线粒体功能障碍的儿童的线粒体功能。该研究旨在研究高风险儿童中线粒体功能异常的可塑性。总而言之，拟议的项目将研究线粒体功能，作为儿童胰岛素抵抗和2型糖尿病的非侵入性预测标记，并试图通过强化运动干预来修饰线粒体功能。儿童线粒体功能障碍的研究既可以识别患有疾病风险的人，又为预防和治疗提供了分子治疗靶标。