Interfacing computational and engineering with digestive and metabolic physiology

将计算和工程学与消化和代谢生理学相结合

• 批准号: 7941400
• 负责人: Santiago Schnell
• 金额: $ 10.8万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7941400
• 关键词: Address; Advisory Committees; Animal Model; Appointment; Area; Bioinformatics; Computational Science; Diabetes Mellitus; Digestive System Disorders; Discipline; Disease; Doctor of Philosophy; Educational process of instructing; Engineering; Enrollment; Ethical Issues; Faculty; Fellowship; Funding; Goals; Health; Informatics; Joints; Laboratories; Laboratory Research; Malignant neoplasm of gastrointestinal tract; Medicine; Mentors; Metabolic; Metabolic Diseases; Metabolism; Michigan; Mission; Molecular; Monitor; National Institute of Diabetes and Digestive and Kidney Diseases; Obesity; Operative Surgical Procedures; Oral; Outcome; Pediatrics; Physiology; Qualifying; Research; Research Personnel; Research Project Grants; Science; Series; Student Selections; Students; Universities; career; computer science; experience; graduate student; lectures; medical schools; programs; public health relevance; symposium

DESCRIPTION (provided by applicant): The purpose of this proposal is develop a program to attract undergraduate and graduate students who are majoring in engineering, informatics and computational disciplines to consider careers in the areas of digestive disease and metabolism and their related health disorders. The program is sponsored by the Department of Molecular & Integrative Physiology at the University of Michigan Medical School, and includes two components. One component is to develop and offer a graduate-level course, which may also be available as an upper-level undergraduate course, to teach physiology, bioinformatics, engineering and computer science students computational applications related to NIDDK research missions such diabetes, obesity and gastrointestinal cancers. It is anticipated that this course will attract graduate students, who have not selected a mentor, to pursue PhD projects related to digestive disease and metabolism. Students will be exposed to the research programs of 17 proposed Program Faculty mentors. All Program Faculty are funded investigators carrying out research in the areas of digestive disease or metabolism, and have primary or joint appointments in Physiology but also have appointments with Medicine, Pediatrics or Surgery. The second component is to establish summer research fellowships that provide opportunities for engineering and computational students to gain laboratory experience in the research areas of digestive or metabolic physiology. Students will attend a noon lecture series that introduces them to multiple aspects of physiology-related research including the use of different model organisms, ethical issues in laboratory research, and career opportunities in biomedical sciences. The research experience will culminate in a half-day symposium that includes oral presentations given by the students summarizing their research projects. Program oversight will be provided by a highly qualified Internal Advisory Committee, and student selection and progress-monitoring will be done by a Student Selection and Mentoring Committee. To maximize the experience, students will be encouraged to enroll in two consecutive summers when possible. Anticipated outcomes include: (i) graduate students from engineering, informatics, and computational sciences will pursue research related to the NIDDK-mission, and (ii) undergraduate students from underrepresented scientific disciplines will perform laboratory research in the areas of digestive and metabolic physiology. We expect this experience to encourage them not only to pursue a research career but to also to consider the exciting opportunities related to solving health problems involving digestive diseases and metabolic disorders. PUBLIC HEALTH RELEVANCE: The goal of the proposed program is to establish a course to teach graduate and undergraduate students from engineering and computational backgrounds the exciting challenges and opportunities pertaining to digestive health and metabolism. The program also offers summer research opportunities to undergraduate engineering students. Our goals are that the offered course and summer research experience will stimulate graduate and undergraduate students to engage in research careers that address the health problems pertaining to digestive disease and metabolic disorders such as diabetes and obesity.

描述（由申请人提供）： 该提案的目的是制定一个计划，吸引工程、信息学和计算学科专业的本科生和研究生考虑从事消化疾病和新陈代谢及其相关健康疾病领域的职业。该计划由密歇根大学医学院分子与综合生理学系赞助，包括两个部分。其中一个组成部分是开发并提供研​​究生课程，该课程也可以作为高年级本科课程，向生理学、生物信息学、工程和计算机科学专业的学生教授与 NIDDK 研究任务（如糖尿病、肥胖症和胃肠道）相关的计算应用癌症。预计该课程将吸引尚未选择导师的研究生攻读与消化疾病和代谢相关的博士项目。学生将接触 17 名拟议项目教师导师的研究项目。所有项目教员都是受资助的研究人员，在消化疾病或新陈代谢领域进行研究，并在生理学方面有主要或联合任命，但也有医学、儿科或外科方面的任命。第二个部分是建立夏季研究奖学金，为工程和计算专业的学生提供获得消化或代谢生理学研究领域的实验室经验的机会。学生将参加中午的系列讲座，向他们介绍生理学相关研究的多个方面，包括不同模式生物的使用、实验室研究中的伦理问题以及生物医学科学的职业机会。研究经验将在为期半天的研讨会中达到高潮，其中包括学生总结其研究项目的口头报告。项目监督将由高素质的内部咨询委员会提供，学生选拔和进度监控将由学生选拔和指导委员会完成。为了最大限度地获得体验，我们鼓励学生在可能的情况下连续两个暑期入学。预期成果包括：(i) 来自工程、信息学和计算科学的研究生将从事与 NIDDK 任务相关的研究，(ii) 来自代表性不足的科学学科的本科生将在消化和代谢生理学领域进行实验室研究。我们希望这种经历不仅能鼓励他们从事研究事业，还能考虑与解决涉及消化疾病和代谢紊乱的健康问题相关的令人兴奋的机会。 公共卫生相关性： 该计划的目标是建立一门课程，向工程和计算背景的研究生和本科生讲授与消化健康和新陈代谢有关的令人兴奋的挑战和机遇。该计划还为工程本科生提供夏季研究机会。我们的目标是，提供的课程和暑期研究经验将刺激研究生和本科生从事研究职业，解决与消化疾病和代谢紊乱（如糖尿病和肥胖症）有关的健康问题。