Interfacing computation and engineering with digestive and metabolic physiology

将计算和工程与消化和代谢生理学相结合

• 批准号: 8999386
• 负责人: Santiago Schnell
• 金额: $ 10.8万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2021-01-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8999386
• 关键词: Address; Advisory Committees; Animal Model; Area; Award; Bachelor' s Degree; Big Data; Biomedical Research; Caenorhabditis elegans; Complex; Diabetes Mellitus; Digestive System Disorders; Discipline; Disease; Doctor of Philosophy; Drosophila melanogaster; Educational process of instructing; Engineering; Enrollment; Ethics; Evaluation; Faculty; Fellowship Program; Genomics; Goals; Health; Interdisciplinary Study; Laboratory Research; Link; Liver diseases; Malignant Neoplasms; Manuscripts; Mathematics; Mentors; Mentorship; Metabolic; Metabolic Diseases; Metabolism; Michigan; Mission; Molecular; Monitor; Mus; National Institute of Diabetes and Digestive and Kidney Diseases; Obesity; Oral; Paper; Physics; Physiological; Physiology; Positioning Attribute; Proteomics; Public Health; Publishing; Qualifying; Recommendation; Recruitment Activity; Reporting; Research; Research Personnel; Research Project Grants; Science; Scientist; Series; Student Selections; Students; System; Technology; Training; Transcend; Transgenic Organisms; Travel; United States National Institutes of Health; Universities; Work; Zebrafish; career; computerized tools; education research; experience; genomic data; innovation; interest; lectures; medical schools; metabolomics; minority student; multi-scale modeling; next generation; programs; public health relevance; statistics; student mentoring; success; summer research; symposium; tool; undergraduate student; Address; Advisory Committees; Animal Model; Area; Award; Bachelor' s Degree; Big Data; Biomedical Research; Caenorhabditis elegans; Complex; Diabetes Mellitus; Digestive System Disorders; Discipline; Disease; Doctor of Philosophy; Drosophila melanogaster; Educational process of instructing; Engineering; Enrollment; Ethics; Evaluation; Faculty; Fellowship Program; Genomics; Goals; Health; Interdisciplinary Study; Laboratory Research; Link; Liver diseases; Malignant Neoplasms; Manuscripts; Mathematics; Mentors; Mentorship; Metabolic; Metabolic Diseases; Metabolism; Michigan; Mission; Molecular; Monitor; Mus; National Institute of Diabetes and Digestive and Kidney Diseases; Obesity; Oral; Paper; Physics; Physiological; Physiology; Positioning Attribute; Proteomics; Public Health; Publishing; Qualifying; Recommendation; Recruitment Activity; Reporting; Research; Research Personnel; Research Project Grants; Science; Scientist; Series; Student Selections; Students; System; Technology; Training; Transcend; Transgenic Organisms; Travel; United States National Institutes of Health; Universities; Work; Zebrafish; career; computerized tools; education research; experience; genomic data; innovation; interest; lectures; medical schools; metabolomics; minority student; multi-scale modeling; next generation; programs; public health relevance; statistics; student mentoring; success; summer research; symposium; tool; undergraduate student

 DESCRIPTION (provided by applicant): The overall long-term goal of our R25 Educational Program "Interfacing computation and engineering with digestive and metabolic physiology" is to attract and encourage undergraduate students who are majoring in engineering, quantitative and computational disciplines to consider careers in digestive health and metabolism and their related diseases. The program is sponsored by the Department of Molecular & Integrative Physiology at the University of Michigan and includes 21 mentors. The focus of this renewal application is to continue but expand the annual summer research fellowship program referred to as STEP (Short Term Educational Program) from 8 to 11 students per summer. During the past four years, we evaluated 119 applications and enrolled 32 different students from across the US, from whom 6 were fellows for 2 years. To maximize the experience, students are encouraged to enroll in two consecutive summers if possible. Notably, 5 of the 6 students who participated in two summers have published at least one paper with their research mentors; 9 of the 32 students are coauthors on at least one manuscript; and 71% of our fellows who have finished their undergraduate degree are attending graduate or medical schools, or hold technical positions in academic biomedical research settings. Our 10 week fulltime summer research experience incorporates a noon lecture series that teaches important physiology and research-related principles, including the use of different model organisms, ethics in laboratory research, and career opportunities in biomedical sciences. The research experience culminates in a mini-symposium, with oral presentations given by the students that summarize their research projects. To further enhance our students' experience, we are incorporating to the program conference travel awards to promote the personalized mentor-trainee relationship beyond the summer; and an alumni mentorship program to link former program fellows, who are pursuing advanced degrees, with actively enrolled STEP students. The Educational Program will continue to be under the oversight of a highly qualified Advisory Committee, and student selection and progress monitoring will be done by a Student Selection and Mentoring Committee. The 2012 NIH Biomedical Workforce estimates that quantitative and computational scientists make up less than 2% of the biomedical science workforce. Therefore, training of quantitative scientists is critical for the advancement of biomedical sciences, especially in the era of big data including complex genomics and proteomics, and multi-scale physiological systems. Our program provides excellent opportunities for undergraduate students from quantitative scientific disciplines to perform laboratory research. We expect this experience to instill excitement and to propel the students to pursue biomedical research- oriented careers, particularly in NIDDK-focused areas of digestive health, metabolism and related diseases. Given what we have accomplished during the past 4 years, and the improvements we propose to implement, we anticipate being able to contribute to the next generation of highly accomplished biomedical scholars.

 描述（应用程序提供）：我们R25教育计划的总体长期目标“将计算和工程与消化和代谢生理学进行连接”是吸引和鼓励主修工程，定量和计算学科主修的本科生，以考虑在消化系统和代谢性及其相关疾病方面的职业生涯。该计划由密歇根大学分子与综合生理学系赞助，其中包括21位导师。该更新申请的重点是继续，但将每年夏天的8至11名学生称为步骤（短期教育计划）的年度夏季研究奖学金计划。在过去的四年中，我们评估了119份申请，并招收了来自美国各地的32名不同的学生，其中6名是研究员2年。为了最大程度地利用体验，鼓励学生在可能的情况下参加两个保守的夏天。值得注意的是，参加两个夏季的6名学生中有5名与他们的研究导师发表了至少一篇论文。在32名学生中，有9名是至少一份手稿的合着者；我们已经有71％的研究生的研究生正在就读研究生或医学院，或者在学术生物医学研究环境中担任技术职位。我们为期10周的全职夏季研究经验结合了一个中午的讲座系列，该系列讲授重要的生理学和研究相关的原理，包括使用不同的模型生物，实验室研究中的伦理和生物医学科学的职业机会。该研究经验最终以迷你群岛为顶点，并由学生提供了总结其研究项目的口头演讲。为了进一步增强学生的经验，我们正在进口计划会议旅行奖，以在夏季以后促进个性化的心理培训关系；以及一个校友心理学计划，旨在将追求高级学位的前计划研究员与积极入学的Step学生联系起来。教育计划将继续受到高度合格的咨询委员会的监督，学生选择和进度监控将由学生选择和指导委员会完成。 2012年NIH生物医学劳动力估计，定量和计算科学家不到生物医学科学劳动力的2％。因此，定量科学家的培训对于生物医学科学的发展至关重要，尤其是在包括复杂基因​​组学和蛋白质组学以及多规模物理系统在内的大数据时代。我们的计划为来自定量科学学科的本科生提供了极好的机会，以进行实验室研究。我们希望这种经验能够灌输兴奋，并推动学生从事以生物医学研究为导向的职业，尤其是在以NIDDK为注重的消化健康，代谢和相关疾病的领域。鉴于我们在过去4年中取得的成就以及我们提出的实施的改进，我们预计能够为下一代高度成就的生物医学学者做出贡献。