Programmable transdermal drug delivery

可编程透皮给药

• 批准号: 7804706
• 负责人: MICAH YAIRI
• 金额: $ 37.44万
• 依托单位: LOS GATOS RESEARCH
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7804706
• 关键词: Affect; Age; Businesses; Chemicals; Child; Clinical Trials; Computers; Data; Diffuse; Diffusion; Disclosure; Disease; Dose; Drug Delivery Systems; Drug Formulations; Elderly; Enhancers; Goals; Gonadal Steroid Hormones; Individual; Injection of therapeutic agent; Length; Leuprolide; Leuprolide Acetate; Life; Link; Malignant Neoplasms; Malignant neoplasm of prostate; Medicine; Methodology; Methods; Microfluidics; Molecular Weight; Pain; Pain-Free; Painless; Patch Tests; Patients; Penetration; Peptides; Performance; Pharmaceutical Preparations; Phase; Population; Precocious Puberty; Process; Proteins; Puberty; Research; Research Project Grants; Risk Management; Safety; Skin; Small Business Innovation Research Grant; Staging; System; Technology; Testing; Time; Transdermal substance administration; United States; United States National Institutes of Health; Woman; Work; Youth; combat; design; dosage; endometriosis; fighting; forgetting; improved; innovation; meetings; men; mortality; new technology; novel; preclinical study; public health relevance; reproductive; verification and validation

DESCRIPTION (provided by applicant): Prostate cancer and central precocious puberty - linked through improper gonadal steroid levels - are most common in either the elderly or youth populations. Similar gonadal steroid problems also connected to endometriosis. Some traditional methodologies for treating these illnesses involves daily injections of medicine, which can become painful or be forgotten, result in under-dosing. Los Gatos Research is developing an alternative method for delivering time-controlled drug formulations that is practically pain free. Furthermore, the novel technology provides an extended, programmable release platform that helps patients avoid the need to remember to take medication (particularly important for portions of the elderly population) and offers the potential to use less medicine to produce the same effect due to the ability to customize the delivery to the individual patient. The technologies developed in this proposed project enable programmable, microfluidic transdermal patches to provide a means for delivering large molecular weight drug formulations that is controlled, painless, and direct. The specific aims of the Phase II project include upgrading the unique programmable transdermal patches, testing and validating their performance capabilities, optimizing them for rapid, controlled delivery of medication to control gonadal steroid levels, and conducting initial pre- clinical trials of the patches.

描述（由申请人提供）：前列腺癌和中央早熟青春期 - 通过性腺类固醇水平不当链接 - 在老年人或青年人群中最常见。类似的性腺类固醇问题也与子宫内膜异位症有关。一些治疗这些疾病的传统方法涉及每天注射药物，可能会变得痛苦或被遗忘，导致剂量不足。 Los Gatos Research正在开发一种替代方法，用于提供实际无疼痛的时间控制药物。此外，这项新技术提供了一个扩展的可编程发行平台，可帮助患者避免记住服用药物（对于部分老年人口尤其重要），并提供较少使用药物来产生相同效果的潜力，因为能够自定义向单个患者提供分娩的能力。在该提出的项目中开发的技术可实现可编程的微流体透皮贴片，以提供一种用于控制，无痛和直接的大分子量药物制剂的方法。第二阶段项目的具体目的包括升级独特的可编程透皮贴片，测试和验证其性能能力，优化它们，以快速，控制的药物递送以控制性腺类固醇水平，并进行斑块的初步临床试验。