The Unique Bioinorganic Chemistry of the Formation of Hydroxyaluminosilicates: A Case to Support a New Graphite Furnace Atomic Absorption Spectrometer

羟基铝硅酸盐形成的独特生物无机化学：支持新型石墨炉原子吸收光谱仪的案例

• 批准号: EP/G00983X/1
• 负责人: Christopher Exley
• 金额: $ 7.06万
• 依托单位: Keele University
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FG00983X%2F1
• 关键词: Unique; Bioinorganic; Chemistry; Formation; Hydroxyaluminosilicates

Research in the Bioinorganic Chemistry Laboratory at Keele University is focussed upon the biological reactivity, availability and essentiality of the second and third most common elements of the Earth's crust, silicon and aluminium. In particular we have shown that aluminium binds silicon in forming hydroxyaluminosilicates and in doing so protects against the known toxicity of aluminium. It is essential to the continuing success of all of the research that we can measure low concentrations of aluminium accurately and reproducibly and we achieve this using instrumentation called a Graphite Furnace Atomic Absorption Spectrometer (GFAAS). Unfortunately our present machine which was bought in 1992 is no longer serviceable and we urgently require to replace it so that all of our research can continue without delay. In this application we have highlighted the ongoing research in our laboratory which uses GFAAS as well as prospective research and our committments to teaching undergraduate and postgraduate students with the view to demonstrating our need for a new GFAAS. Funds to support the buying of a new GFAAS are the subject of this application.

基尔大学生物无机化学实验室的研究重点是地壳中第二和第三常见元素硅和铝的生物反应性、可用性和必要性。特别是，我们已经证明，铝与硅结合形成羟基铝硅酸盐，从而防止铝的已知毒性。对于所有研究的持续成功至关重要，我们能够准确且可重复地测量低浓度的铝，并且我们使用称为石墨炉原子吸收光谱仪 (GFAAS) 的仪器来实现这一目标。不幸的是，我们现有的 1992 年购买的机器已无法使用，我们迫切需要更换它，以便我们所有的研究能够立即继续。在此申请中，我们重点介绍了我们实验室正在进行的使用 GFAAS 的研究以及前瞻性研究，以及我们对本科生和研究生教学的承诺，以证明我们对新 GFAAS 的需求。支持购买新 GFAAS 的资金是本申请的主题。

项目成果

Aluminium in the human brain

铝在人脑中的作用

• DOI: 10.1007/s00706-010-0417-y
• 发表时间: 2011-04-01
• 期刊: Monatshefte für Chemie - Chemical Monthly
• 作者: C. Exley;E. House
• 通讯作者: E. House

Towards a model of non-equilibrium binding of metal ions in biological systems.

建立生物系统中金属离子非平衡结合的模型。

• DOI: http://dx.10.1016/j.jinorgbio.2008.10.003
• 发表时间: 2009
• 期刊: Journal of inorganic biochemistry
• 影响因子: 3.9
• 作者: Beardmore J

New insight into silica deposition in horsetail (Equisetum arvense).

对问荆（Equisetum arvense）中二氧化硅沉积的新见解。

• DOI: http://dx.10.1186/1471-2229-11-112
• 发表时间: 2011
• 期刊: BMC plant biology
• 影响因子: 5.3
• 作者: Law C

There is (still) too much aluminium in infant formulas.

婴儿配方奶粉中的铝含量（仍然）过多。

• DOI: http://dx.10.1186/1471-2431-10-63
• 发表时间: 2010
• 期刊: BMC pediatrics
• 影响因子: 2.4
• 作者: Burrell SA