600 MHz NMR Spectrometer Console

600 MHz 核磁共振波谱仪控制台

• 批准号: 7212707
• 负责人: David Joseph Weber
• 金额: $ 36.24万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7212707
• 关键词: AIDS/HIV problem; Acids; Address; Aging; Amino Acids; Arts; Bacteriophages; Baltimore; Binding; Biotechnology; Brain; Cancer Center; Catalytic Domain; DNA; Drug Design; Equipment; Faculty; Failure; Funding; Heart Diseases; Human; Malignant Neoplasms; Maryland; Metabolism; Mismatch Repair; NGFRAP1 gene; NMR Spectroscopy; Pharmacy Schools; Principal Investigator; Proteins; Public Health; Rate; Research; S100 Proteins; Structure; Time; United States National Institutes of Health; Universities; cryogenics; instrumentation; medical schools; member; trafficking

DESCRIPTION (provided by applicant): NIH-funded principal investigators at the University of Maryland, Baltimore have a scientific need for a state-of-the-art 600 MHz NMR spectrometer console to carry out their NIH funded NMR-related research. This equipment is necessary to (i) become state-of-the art, (ii) to adequately protect our cryogenic probe and (iii) to reduce the amount of NMR down-time resulting from the high failure rate of our existing 600 MHz instrumentation. The users of the UMB NMR center include faculty members from the School of Medicine, the School of Pharmacy, the Greenebaum Cancer Center, the University of Maryland Biotechnology center, and users from other universities and private companies. The ongoing NIH-funded projects that are dependent upon the 600 MHz NMR spectrometer include: 1. Dr. David J. Weber (PI), Structure/function and drug design for S100 proteins; 2. Dr. Lindsay Black, Structure/function studies of the phage IPI protein; 3. Dr. Alex Drohat, The structure of the human TDG catalytic core by NMR spectroscopy; 4. Dr. A-Lien Lu-Chang, Structural and Mechanistic Studies of DNA Mismatch Repair Proteins, 5. Dr. Frank Margolis, Structure/function studies of OMP bound to the Bex proteins; 6. Dr. Mary McKenna, Monocarboxylic acids and amino acids in metabolism and trafficking in the brain; 7. Dr. James Nataro, Structure/Function studies of Dispersin; 8. Dr. Kristen Varney, Structure and Function of Mts1 (S100A4). In addition, four other projects are briefly described in this application, which also have an essential need for continued use of the 600 MHz NMR spectrometer. Relevance: The ongoing NMR-related projects under study by NIH-funded principal investigators at the University of Maryland, Baltimore address many important public health concerns including cancer, HIV/AIDS, aging, heart disease, and several aspects of drug design.

描述（由申请人提供）：巴尔的摩马里兰大学的 NIH 资助的主要研究人员对最先进的 600 MHz NMR 波谱仪控制台有科学需求，以开展 NIH 资助的 NMR 相关研究。该设备对于 (i) 成为最先进的设备、(ii) 充分保护我们的低温探头以及 (iii) 减少因我们现有 600 MHz 仪器的高故障率而导致的 NMR 停机时间是必要的。 UMB NMR 中心的用户包括来自医学院、药学院、格林鲍姆癌症中心、马里兰大学生物技术中心的教职人员以及来自其他大学和私营公司的用户。 NIH 正在资助的依赖 600 MHz NMR 波谱仪的项目包括： 1. David J. Weber 博士（PI），S100 蛋白的结构/功能和药物设计； 2. Lindsay Black博士，噬菌体IPI蛋白的结构/功能研究； 3. Alex Drohat 博士，通过核磁共振波谱分析人类 TDG 催化核心的结构； 4. A-Lien Lu-Chang 博士，DNA 错配修复蛋白的结构和机制研究，5. Frank Margolis 博士，OMP 与 Bex 蛋白结合的结构/功能研究； 6. Mary McKenna 博士，单羧酸和氨基酸在大脑中的代谢和运输； 7. James Nataro博士，Dispersin的结构/功能研究； 8. Kristen Varney 博士，Mts1 (S100A4) 的结构和功能。此外，本申请中还简要描述了其他四个项目，这些项目也对继续使用 600 MHz NMR 波谱仪有基本需求。 相关性：由 NIH 资助的巴尔的摩马里兰大学主要研究人员正在研究的核磁共振相关项目解决了许多重要的公共卫生问题，包括癌症、艾滋病毒/艾滋病、衰老、心脏病和药物设计的几个方面。