Focal Structure-Function Relationships in Macular Layers from 3D Spectral OCT

3D 光谱 OCT 黄斑层的焦点结构-功能关系

• 批准号: 7729130
• 负责人: Michael David Abramoff
• 金额: $ 35.85万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7729130
• 关键词: 3-Dimensional; Address; Adherence; Age; Age Distribution; Age-Years; Anatomy; Anterior; Anterior Ischemic Optic Neuropathy; Axon; Biometry; Burn injury; Characteristics; Clinical; Collaborations; Data; Data Analyses; Devices; Enrollment; Environment; Eye; Frequencies; Glaucoma; Image; Image Analysis; Imaging Device; Knowledge; Link; Location; Measures; Medical Imaging; Methods; Monitor; Morphology; Neuropathy; Ophthalmologist; Ophthalmology; Optical Coherence Tomography; Papillary; Patients; Perimetry; Productivity; Property; Protocols documentation; Qualifying; Reproducibility; Research; Research Personnel; Retina; Retinal; Retinal Diseases; Retinal Ganglion Cells; Structural Models; Structure; Structure-Activity Relationship; Study Subject; Testing; Texture; Thick; Three-Dimensional Image; Three-dimensional analysis; Tissues; Vision; Visual; Visual Fields; Work; age difference; base; central visual field; design; disease diagnosis; experience; functional status; ganglion cell; imaging Segmentation; in vivo; indexing; macula; member; novel strategies; optic nerve disorder; patient oriented research; predictive modeling; public health relevance; relating to nervous system; retinal nerve fiber layer

DESCRIPTION (provided by applicant): This proposal seeks to elucidate the structure-function relationships between visual field threshold sensitivity and the structural features of the retinal layers. The study will address which structural properties of the layers of the macula - obtained from three-dimensional image analysis of spectral domain optical coherence tomography (3-D OCT) - are associated with visual sensitivity, a measure of function. Specifically, we will investigate how structural measures of localized columnar regions of the macula, including layer thickness and texture, are associated with the threshold sensitivity of those macular columns measured at corresponding locations in the central 10 degrees with 10-2 perimetry. The project is driven by an important clinical problem - the poor reliability and reproducibility of the visual field as a measure of irreversible damage to the retinal ganglion cells and their axons in optic neuropathies including glaucoma. If the expected associations are confirmed by 3-D image analysis of spectral domain OCT of the macular layers, the new approach has the potential to become an objective and reproducible addition to the functional assessment of the status of damage. The overriding hypothesis motivating the proposed research is that macular visual sensitivity can be predicted from macular structure and texture properties as imaged and quantified by comprehensive analysis of 3-D spectral-domain OCT. We have identified the following specific aims: Aim 1: Refine and validate our existing method of segmenting retinal layers from 3-D spectral OCT images; derive global and focal structural indices, such as thickness and texture, of each retinal layer in the peripapillary and the macular regions of the retina in normal eyes and in eyes with central visual field damage from glaucoma and anterior ischemic optic neuropathy. Aim 2: Determine how the structural indices derived from the retinal ganglion cell and other intraretinal layers in the macula correlate with the thickness of the corresponding ganglion cell axons in the retinal nerve fiber layer. This will be demonstrated in normal eyes and in eyes with a wide range of macular sensitivity loss from glaucoma and anterior ischemic optic neuropathy. Aim 3: Model the structural-functional relationships in the macula by comparing and registering visual sensitivity at 68 locations (Humphrey 10-2 test averaged over 3 repeats) with their corresponding structural indices of the segmented layers. Derive a predictive model of function from structural properties of the macular layers in the same set of normal and damaged eyes used in Aim 2. The work will be performed in in-vivo acquired 3-D OCT images accompanied by visual field sensitivity test data from 30 normal, 5 glaucoma, and 20 unilateral anterior ischemic optic neuropathy subjects. PUBLIC HEALTH RELEVANCE: Three dimensional spectral OCT imaging provides a wealth of information about the morphology and tissue characteristics of retinal layers. We propose to study structural and functional relationships of the macular intraretinal layers using this new 3-D OCT imaging device. This study has potentially important consequences for glaucoma, anterior ischemic neural neuropathy, and other retinal disease diagnosis and treatment.

描述（由申请人提供）：该提案旨在阐明视场阈值灵敏度与视网膜层的结构特征之间的结构功能关系。该研究将解决黄斑层的结构特性 - 从光谱结构域光学相干断层扫描（3 -D OCT）的三维图像分析（3 -d OCT）获得与视觉灵敏度有关，这是功能的度量。具体而言，我们将研究黄斑的局部柱状区域的结构测量，包括层厚度和纹理，与这些黄斑柱的阈值敏感性有关，这些黄斑柱在中央10度的相应位置测量的阈值敏感性，并具有10-2度。该项目是由一个重要的临床问题驱动的 - 视野的可靠性和可重复性差，是对视网膜神经节细胞及其轴突不可逆转的损害，包括青光眼（包括青光眼）。如果通过对黄斑层的光谱域OCT的3-D图像分析确认了预期的关联，则新方法有可能成为对损害状态的功能评估的客观且可重复的添加。促成拟议研究的覆盖假设是，可以通过对3-D光谱域OCT的全面分析对黄斑的视觉灵敏度和纹理特性预测。我们已经确定了以下特定目标：目标1：完善并验证我们现有的从3-D光谱OCT图像分割视网膜层的方法；在正常眼睛的围角毛皮毛皮毛皮和黄斑区域，在正常眼睛的围角和黄斑区域中，得出全局和局灶性结构指标，例如厚度和纹理，在正常的眼睛和眼睛中，具有青光眼和缺血性视野神经性神经性神经性神经性的中央视野损害。 AIM 2：确定黄斑中的视网膜神经节细胞和其他视网膜内层的结构指标与视网膜神经纤维层中相应神经节细胞轴突的厚度相关。这将在正常的眼睛和眼睛中证明，在青光眼和前缺血性视神经病变中具有广泛的黄斑敏感性丧失。 AIM 3：通过比较和记录68个位置（Humphrey 10-2测试平均3个重复测试）的视觉灵敏度与它们的相应结构指标的相应结构指标，通过比较和记录视觉敏感性。在AIM 2中使用的一组正常和受损的眼睛中，从黄斑层的结构特性中得出一个功能的预测模型。该工作将在Vivo中获得的3-D OCT图像进行3-D OCT图像，并带有来自视野灵敏度测试数据30个正常，5个青光眼和20个单侧缺血性视神经病变受试者。公共卫生相关性：三维光谱OCT成像提供了有关视网膜层的形态和组织特征的大量信息。我们建议使用这种新的3-D OCT成像装置研究黄斑内层的结构和功能关系。这项研究对青光眼，前缺血性神经病以及其他视网膜疾病诊断和治疗产生了重要的影响。