Retinal Therapy Guided by 3-D OCT Image Analysis

3-D OCT 图像分析引导的视网膜治疗

• 批准号: 8268455
• 负责人: Michael David Abramoff
• 金额: $ 52.69万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2015-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8268455
• 关键词: 3-Dimensional; Address; Adopted; Adverse event; Affect; Aftercare; Age related macular degeneration; American; Back; Biological Preservation; Biometry; Blindness; Choroidal Neovascularization; Chronic; Clinical; Clinical assessments; Cyst Fluid; Data Analyses; Disease; Dose; Endophthalmitis; Exudate; Eye; Goals; Human Characteristics; Image; Image Analysis; Imaging Device; Individual; Infection; Injection of therapeutic agent; Institutes; Interdisciplinary Study; Iowa; Light; Measures; Medical Imaging; Medicine; Methods; Modeling; Morphology; Optical Coherence Tomography; Outcome; Pathology; Patients; Performance; Phase; Property; Protocols documentation; Reaction Time; Reading; Recurrence; Reproducibility; Research; Research Infrastructure; Research Personnel; Resolution; Retina; Retinal; Retreatment; Risk; Scanning; Slice; Specialist; Structure; Thick; Three-dimensional analysis; Time; Tissues; Translational Research; Treatment outcome; Validation; Vision; Visual Acuity; Work; abstracting; base; bevacizumab; bioimaging; cost effective; follow-up; improved; in vivo; indexing; legally blind; macula; novel; response; restoration; success; tool; treatment response; two-dimensional

Abstract: Age related macular degeneration (AMD) is one of the primary causes of blindness in the U.S. A wealth of powerful new treatments, especially anti-VEGF agents, have recently become available to restore visual function in choroidal neovascularization (CNV), the most severe form of AMD. The risk of ocular adverse events increases with repeated intravitreal treatment injections. Ideally a patient-specific dosing strategy with the minimally necessary number of anti-VEGF injections would be employed. This study will address which patient-specific properties of the intra- and sub-retinal fluid, cysts, and retinal layers of the macula (obtained from 3D spectral domain optical coherence tomography or OCT) (i) are associated with individual response to anti-VGEF treatment, and (ii) can predict proper treatment timing and response. The main hypothesis motivating the proposed research is that a model of retinal response to initial anti-VEGF treatment for CNV, based on quantitative 3D OCT-derived measures, can predict the timing of retreatment. We have identified the following specific aims: Aim 1: Further refine and validate a comprehensive set of analysis methods and approaches for 3D spectral OCT image analysis in the presence of wet AMD pathology (Symptomatic Exudate Associated Derangements or SEADs) and assess its performance by comparison to expert analyses. Aim 2: Determine associations between standard 2D Spectralis OCT clinical readings from retinal specialists and quantitative SEAD- and layer-derived measures from 3D Cirrus OCT. Aim 3: Determine how well the quantitative SEAD- and layer-derived measures from 3D OCT predict the patient-specific outcome parameters in response to post-induction anti-VEGF treatment in patients with CNV, in order to predict the timing of retreatment. The work will be performed prospectively in in-vivo spectral-domain OCT images acquired during the course of CNV disease treatment. We will repeatedly image 200 patients with choroidal neovascularization before and during treatment and during the 1-year follow-up phase.

抽象的： 与年龄相关的黄斑变性（AMD）是美国失明的主要原因之一，尤其是抗VEGF药物，最近已用于恢复脉络膜新生血管形成（CNV）的视觉功能（CNV），这是AMD最严重的形式。眼部不良事件的风险随着玻璃体内治疗的反复注射而增加。理想情况下，将采用特定于患者的剂量策略，并使用最少必要的抗VEGF注射量。这 研究将解决黄斑内和视网膜下液，囊肿和视网膜层的患者特异性特异性（从3D光谱域光学相干断层扫描或OCT）（I）（I）（I）（i）与抗VGEF治疗的个体反应有关，并且（II）可以预测适当的治疗时间和反应。 促使拟议研究的主要假设是，基于定量3D OCT的测量方法，对CNV初始抗VEGF处理的视网膜反应模型可以预测撤退的时间。 我们已经确定了以下具体目标： 目标1：进一步完善并验证3D的全面分析方法和方法 在存在湿AMD病理学的情况下，光谱OCT图像分析（有症状的渗出液 与专家相比，通过相关的乱扰或钉）并评估其性能 分析。 AIM 2：确定视网膜标准2D光谱OCT临床读数之间的关联 来自3D Cirrus Oct的专家和定量壁式和层衍生的措施。 目标3：确定从3d OCT预测的定量SEAD和层衍生的措施 针对诱导后抗VEGF治疗的患者特异性结果参数 CNV患者，以预测撤退的时间。 这项工作将在体内光谱域的OCT图像中前瞻性执行 CNV疾病治疗过程。我们将反复成像200例脉络膜患者 在治疗前后，在1年的随访阶段进行新血管化。