CARING FOR A CHILD WITH SERIOUS ILLNESS PROJECT (CCI PROJECT)

照顾患有严重疾病的儿童项目（CCI 项目）

• 批准号: 7724364
• 负责人: DOROTHY A GLOVER
• 金额: $ 0.52万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7724364
• 关键词: Acute; Asthma; Autistic Disorder; Biological; Biological Markers; Brain; Caring; Catecholamines; Child; Chronic; Chronic stress; Computer Retrieval of Information on Scientific Projects Database; Data; Development; Diabetes Mellitus; Diagnosis; Diastolic blood pressure; Dopamine; Epilepsy; Epinephrine; Female; Funding; Future; Grant; Hip region structure; Hippocampus (Brain); Hormones; Human; Hydrocortisone; Individual; Institution; Magnetic Resonance Imaging; Major Depressive Disorder; Malignant Neoplasms; Mothers; Norepinephrine; Numbers; Participant; Post-Traumatic Stress Disorders; Prevention; Research; Research Personnel; Resources; Source; Stress; Structure; Symptoms; System; United States National Institutes of Health; allostatic load; coping; disturbance in affect; experience; hypothalamic-pituitary-adrenal axis; response; size; urinary

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. 'There are a number of biological systems that regulate the human response to stress, including the hypothalamic-pituitary-adrenal (HPA) axis which produces hormones like cortisol and catecholamines. Dysregulation in these systems is sometimes called "allostatic load" or AL. Studies have shown AL dysregulation and a smaller hippocampus (a brain structure) among individuals with chronic posttraumatic stress disorder (PTSD) and major depressive disorder (MDD). However, we do not know the exact relationship between AL system dysregulation and hippocampal size among individuals who have experienced acute and chronic stress. Also, we do not know if the relationship depends on the presence of current PTSD or MDD symptoms. Perhaps AL and structural brain changes can also be seen in stressed individuals without symptoms. This project investigates the relationship between biomarkers of stress-influenced biological systems (AL) and hippocampal size. Research participants will consist of female primary careproviders (e.g., mothers) of children who have been diagnosed with a serious illness such as cancer, epilepsy, asthma, diabetes or autism. Previous research has shown that some mothers will develop symptoms of PTSD or MDD and some will not, but all will undergo chronic stress as they cope with their child's illness and its treatment. Thus, it will be possible to study stress-system dysregulation and hippocampal size in relation to PTSD or MDD. Mothers of children with a serious illness will be assessed for a) PTSD, MDD and other related symptoms of mood disturbance; b) dysregulation in stress-influenced biological systems (AL: urinary cortisol, dopamine, norepinephrine and epinephrine; systolic and diastolic blood pressure; and waist-to-hip ratio) and c) reduced hippocampal size (via Magnetic Resonance Imaging (MRI). The study will provide much-needed data on the impact of acute and chronic stress on biological systems and brain structure and may help in the development of prevention and treatment efforts in the future.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 ``有许多生物系统可以调节人类对应激的反应，包括下丘脑 - 垂体 - 肾上腺（HPA）轴，该轴产生了皮质醇和儿茶酚胺等激素。 这些系统中的失调有时称为“同性载荷”或AL。 研究表明，慢性创伤后应激障碍（PTSD）和主要抑郁症（MDD）患者中的AL失调和较小的海马（大脑结构）。但是，我们不知道经历了急性和慢性压力的个体中系统失调和海马大小之间的确切关系。 另外，我们不知道这种关系是否取决于当前PTSD或MDD症状的存在。 也许在没有症状的压力个体中也可以看到AL和结构性大脑的变化。 该项目研究了受压力影响的生物系统（AL）和海马大小之间的关系。 研究参与者将由被诊断出患有严重疾病的儿童（例如癌症，癫痫，哮喘，哮喘，糖尿病或自闭症）的儿童组成。 先前的研究表明，有些母亲会出现PTSD或MDD的症状，而有些则不会，但是当他们应对孩子的疾病及其治疗时，所有母亲都会承受慢性压力。 因此，与PTSD或MDD有关的应力系统失调和海马大小可能会研究应力系统失调。 患有严重疾病的儿童的母亲将被评估为A）PTSD，MDD和其他相关的情绪障碍症状； b）受压力影响的生物系统（AL：尿皮质醇，多巴胺，去甲肾上腺素和肾上腺素；收缩和舒张血压；以及腰椎比）以及C）以及C）降低海马大小（通过磁性成像（MIRI）降低了脑结构，并在脑结构上降低了，并且在脑结构上有很多影响，并且在脑结构上有帮助，并且在脑结构上有帮助，并且在脑部的脑力成像时，均质和腰部均具有影响，并且腰部和腰部的影响力很大。未来预防和治疗工作的发展。