GENETICS OF PEDIATRIC BIPOLAR DISORDER

儿科双相情感障碍的遗传学

• 批准号: 7723440
• 负责人: YUQUN LUO
• 金额: $ 0.45万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7723440
• 关键词: Age; Alzheimer' s Disease; Applications Grants; Bipolar Disorder; Caring; Child; Childhood; Chronic; Clinical; Complex; Computer Retrieval of Information on Scientific Projects Database; Computer software; Data Collection; Development; Diagnosis; Diagnostic; Evolution; Family history of; Funding; Genes; Genetic; Genetic Determinism; Grant; Hereditary Disease; Institution; Manic; Mental disorders; Methods; Research; Research Personnel; Resources; Risk Factors; Source; Statistical Methods; Symptoms; United States National Institutes of Health; early onset; genetic analysis; genetic risk factor; malignant breast neoplasm; novel; psychosocial; segregation; success

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Pediatric Bipolar Disorder (PBD) is a spectrum of chronic debilitating illness characterized by elevated symptoms of mania (ESM). We aim to study the phenomenology, diagnostic evolution, psychosocial functioning, family history and risk factors (including genetic risk factors) of 600 children ages 6-12 years who present for clinical care with ESM regardless of their bipolarity diagnosis. Bipolar disorder, being one of the most familial, heritable, and well-defined mental disorders, has attracted tremendous effort to unravel its genetic determinants. Presenting the same challenges to genetic analysis as many other complex genetic diseases, it has also greatly stimulated the development of novel statistical genetic methods over the past two decades. The effort to locate the underlying genes, however, has not met with much success. Pediatric Bipolar Disorder, together with its subtypes, is recognized as potentially more genetically loaded and homogeneous. Hence, genetic analysis focusing on this earlier onset form might be more profitable, considering the breakthroughs in the quest for underlying genes of breast cancer and Alzheimer's disease, through similar strategies. A grant proposal "Longitudinal Assessment of Manic Symptoms" to study the genetics of pediatric bipolar disorder has recently been funded and data collection started. Existing methods implemented in the S.A.G.E. software, as well as newly developed statistical methods suitable for the challenge posed by the genetic analysis of PBD, will be employed to perform segregation, linkage and association analyses.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 小儿双相情感障碍 (PBD) 是一系列慢性衰弱性疾病，其特征是躁狂症状 (ESM) 升高。我们的目标是研究 600 名 6-12 岁儿童的现象学、诊断演变、心理社会功能、家族史和风险因素（包括遗传风险因素），这些儿童无论是否患有双相情感障碍诊断，都接受 ESM 临床护理。双相情感障碍是最具家族性、遗传性和明确定义的精神障碍之一，人们为解开其遗传决定因素付出了巨大的努力。与许多其他复杂的遗传疾病一样，它给遗传分析带来了同样的挑战，但在过去的二十年里也极大地刺激了新型统计遗传方法的发展。然而，寻找潜在基因的努力并没有取得太大成功。儿童双相情感障碍及其亚型被认为可能具有更多的遗传负荷和同质性。因此，考虑到通过类似的策略在寻找乳腺癌和阿尔茨海默病的潜在基因方面取得的突破，专注于这种早期发病形式的遗传分析可能会更有利可图。一项研究儿童双相情感障碍遗传学的拨款提案“躁狂症状的纵向评估”最近已获得资助并开始数据收集。 S.A.G.E. 中实施的现有方法。软件以及新开发的适合PBD遗传分析挑战的统计方法将用于进行分离、连锁和关联分析。