FASEB Conference on Protein Kinases

FASEB 蛋白激酶会议

• 批准号: 7331403
• 负责人: JOHN BLENIS
• 金额: $ 0.5万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7331403
• 关键词: Academia; Affect; Biochemical; Biological Process; Cell physiology; Communication; Communication Research; Development; Disease; Enzymes; Goals; Growth and Development function; Human; Human Genome; Industry; Knowledge; Modification; Molecular; Pathway interactions; Phosphorylation; Phosphotransferases; Play; Protein Kinase; Protein Kinase Protein Phosphorylation; Regulation; Research; Role; Scientist; Signal Pathway; Signal Transduction; Therapeutic Intervention; Time; base; computerized data processing; developmental disease; human disease; improved; novel therapeutics; symposium; therapeutic target; transmission process

DESCRIPTION (provided by applicant): The goal of the signal transduction field is to identify and characterize the biochemical and molecular basis of communication from one molecule to another as part of a signaling pathway. Over the last 30 years, this knowledge has provided a vastly improved understanding of how transfer of this information regulates a variety of cellular processes associated with normal growth and development. Unfortunately, these pathways are also the targets of inappropriate regulation through an assortment of mechanisms, and when this occurs a variety of human developmental disorders and diseases can arise. The structural modification of proteins by phosphorylation is now well established to be a major mechanism of modulating signaling processes. There are over 500 protein kinases in the human genome with the potential to regulate protein phosphorylation, but relatively few are well characterized. Of those that are, many are now known to possess important functions in normal development and disease. Because of the central role these enzymes play in a variety of biological processes and in many human diseases, and because protein kinases are potential targets for therapeutic intervention, a tremendous effort has been made at determining the molecular basis for information transmission and the biological processes affected. The characterization of new kinases and their functions will likely reveal even more novel therapeutic targets. These are truly exciting times in the protein kinase and protein phosphorylation arena. Thus, it is critical that the exchange of information and ideas between the leading scientists in the field occur in order for this scientific discovery to proceed. Since its inception in 1983, the FASEB summer research conference on "Protein Kinases and Protein Phosphorylation" (held biennially) has consistently been one of the preeminent meetings in the field of signal transduction, providing a premier venue for the communication of research findings from both academia and industry. The goal of the proposed conference is to continue this tradition of exciting and enthusiastic scientific exchange.

描述（由申请人提供）：信号转导领域的目标是识别和表征作为信号传导途径一部分的从一个分子到另一个分子的通信的生化和分子基础。 在过去的 30 年里，这些知识极大地加深了人们对信息传递如何调节与正常生长和发育相关的各种细胞过程的理解。 不幸的是，这些途径也是通过各种机制进行不当调节的目标，当这种情况发生时，可能会出现各种人类发育障碍和疾病。 通过磷酸化对蛋白质进行结构修饰现已被确定为调节信号传导过程的主要机制。 人类基因组中有超过 500 种蛋白激酶具有调节蛋白磷酸化的潜力，但得到充分表征的蛋白激酶相对较少。 其中，许多现在已知在正常发育和疾病中具有重要功能。 由于这些酶在多种生物过程和许多人类疾病中发挥着核心作用，并且蛋白激酶是治疗干预的潜在靶标，因此人们在确定信息传递的分子基础和受影响的生物过程方面付出了巨大的努力。 。 新激酶及其功能的表征可能会揭示更多新的治疗靶点。 这是蛋白激酶和蛋白磷酸化领域真正激动人心的时刻。 因此，为了使这一科学发现得以继续，该领域的顶尖科学家之间进行信息和思想的交流至关重要。 自 1983 年成立以来，FASEB 关于“蛋白激酶和蛋白磷酸化”的夏季研究会议（每两年举行一次）一直是信号转导领域的杰出会议之一，为交流双方的研究成果提供了首要场所。学术界和工业界。 拟议会议的目标是延续这种令人兴奋和热情的科学交流的传统。