MENDELIAN RANDOMIZATION TO INFER CAUSATION IN OBSERVATIONAL EPIDEMIOLOGY

孟德尔随机化在观察流行病学中推断因果关系

• 批准号: 7723460
• 负责人: MURIELLE BOCHUD
• 金额: $ 0.45万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7723460
• 关键词: Affect; Alleles; Birth; Causations; Computer Retrieval of Information on Scientific Projects Database; Conceptions; Epidemiology; Funding; Germ Cells; Grant; Institution; Laws; Mind; Observational Study; Parents; Randomized; Research; Research Personnel; Resources; Source; United States National Institutes of Health; segregation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Currently, little is known about the mechanisms that distort the distribution of alleles from that expected from Mendel's first law between gamete formation, conception, birth and entry into a study. It is therefore difficult to estimate the extent to which these mechanisms may affect the results of Mendelian randomization studies. However, these mechanisms should not be assumed to be negligible until they have been properly evaluated. Potential for segregation distortion, selective survival and parent-of-origin effect should be kept in mind when conducting Mendelian randomization studies to draw causal inference in observational studies.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 目前，关于扭曲的机制知之甚少 等位基因从门德尔的期望中分布 配子形成，构想，出生和 进入研究。因此，很难估计 这些机制可能会影响门德尔的结果 随机研究。但是，这些机制不应 假定在正确之前可以忽略不计 评估。隔离失真，选择性生存的潜力 并在 进行孟德尔随机研究以绘制因果关系 观察性研究的推论。