MULTIMODAL SPECTROSCOPY PROBE DEVELOPMENT

多模态光谱探头开发

• 批准号: 7722788
• 负责人: OBRAD SCEPANOVIC
• 金额: $ 3.81万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7722788
• 关键词: Atherosclerosis; Clinical; Collection; Computer Retrieval of Information on Scientific Projects Database; Coupling; Development; Diagnosis; Diagnostic; Fiber; Fluorescence; Funding; Grant; Institution; Light; Location; Modality; Operative Surgical Procedures; Optics; Raman Spectrum Analysis; Range; Research; Research Personnel; Resources; Signal Transduction; Source; Spectrum Analysis; Tissues; United States National Institutes of Health; base; design; desire; in vivo; instrument; malignant breast neoplasm

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are investigating the utility of combining diagnostic information from reflectance and fluorescence to that obtained by Raman spectroscopy  termed multimodal spectroscopy (MMS) - to diagnose atherosclerosis and breast cancer. As a result, a single spectral probe is being developed to be used with all three modalities. The combined probe would take excitation light from existing reflectance, fluorescence, and Raman sources and deliver to and collect the light from the same tissue location. The combined probe is designed to be capable of delivering and collecting light in the 300-1000 nm spectral range. Based on the in vivo Raman probe that has been successful used in the surgical theatre, the combined probe will enable the coupling of multiple sources into its single excitation fiber, incorporate excitation and emission filters with specially designed optical coatings to suppress fiber background and enable efficient extraction of the desired signal. Collection fibers would be split up and be directed to two spectrograph/CCD modules of the clinical MMS instrument for spectral analysis and parameter extraction.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 我们正在研究将诊断信息从反射率和荧光结合到称为多模式光谱法（MMS）获得的诊断信息，以诊断动脉粥样硬化和乳腺癌。结果，正在开发单个光谱探针与所有三种方式一起使用。合并后的探针将从现有的反射率，荧光和拉曼来源中获得激发光，并从同一组织位置传递并收集光。合并的探针设计为能够在300-1000 nm光谱范围内传递和收集光。基于在手术剧院中成功使用的体内拉曼探针，合并的探针将使多个来源耦合到其单个激发纤维中，将激发和发射过滤器与特殊设计的光纤涂层结合起来，以抑制纤维背景，并有效地提取所需信号。收集纤维将被拆分，并将其定向到临床MMS仪器的两个光谱仪/CCD模块，以进行光谱分析和参数提取。