DNA DESIGNER CRYSTALS

DNA 设计师水晶

• 批准号: 7726269
• 负责人: JENS J BIRKTOFT
• 金额: $ 0.79万
• 依托单位: BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-18 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7726269
• 关键词: Binding; Computer Retrieval of Information on Scientific Projects Database; Crystallization; DNA; Funding; Goals; Grant; Institution; Ligands; Memory; Optics; Research; Research Personnel; Resources; Sorting - Cell Movement; Source; Structure; System; United States National Institutes of Health; base; design; macromolecule; nanoelectronics; nanoscale; programs; prototype; scaffold; three dimensional structure

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our research program is designed to utilize new types of macromolecular building blocks, based on branched DNA, as the basis of specific 3D structural designs. The goal of developing the systems is eventually to provide a macromolecular scaffolding, capable of binding, orienting and juxtaposing a variety of molecules, from cellular macromolecules to organic conductors and optical memory components. We propose to determine the structures of 3D periodic arrays, which represent the first designed 3D systems of this sort. The ultimate goal here is to use these arrays to prototype a general form of macromolecular crystallization, in which the DNA components form the host lattice and all crystalline contacts, and macromolecular guests are aligned within the cavities present. This system is likely to enable the initial crystallization of macromolecular species previously intractable to such ordering, and it is also designed to allow analysis of previously crystallized molecules bound to ligands whose presence disrupts their conventional lattices. The ability to produce specific structures on the nanoscale should also enable us to use this system to produce ordered arrangements of so-called cargo hetero-molecules that are attached to the DNA units. Thus, the organization of nanoelectronic components in 3D, leading to smaller and presumably faster computation will likely result from this research

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此，可以在其他清晰的条目中表示。列出的机构是 对于中心，这不一定是调查员的机构。 我们的研究计划旨在利用基于分支DNA的新型大分子构建块作为特定的3D结构设计的基础。开发系统的目的最终是提供一个大分子脚手架，能够结合，定向和并置从细胞大分子到有机导体和光学记忆成分的各种分子。我们建议确定3D周期阵列的结构，这代表了此类设计的第一个设计的3D系统。这里的最终目标是使用这些阵列原型制作大分子结晶的一般形式，其中DNA成分形成宿主晶格和所有结晶触点，而大分子来宾则在存在的腔内对齐。该系统可能能够使以前对这种有序的大分子物种的初始结晶化，并且还旨在分析以前结晶的分子与配体的结合，而配体的存在会破坏其常规的晶格。在纳米级上生产特定结构的能力也应使我们能够使用该系统来生成附着在DNA单元上的所谓货物异质分子的有序排列。因此，在3D中组织纳米电子成分，可能会导致较小且可能更快的计算。