CRYSTALLOGRAPHIC STUDIES OF TRANSPORTERS AND RECEPTORS

转运体和受体的晶体学研究

• 批准号: 7722058
• 负责人: James E Gouaux
• 金额: $ 0.02万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7722058
• 关键词: Aspartate; Computer Retrieval of Information on Scientific Projects Database; Data; Funding; Gated Ion Channel; Grant; Institution; Integral Membrane Protein; Ion Channel Protein; L-Selenomethionine; Leucine; Ligands; Phase; Research; Research Personnel; Resolution; Resources; Source; United States National Institutes of Health; receptor; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We have crystals of multiple integral membrane protein transporters and ligand-gated ion channel receptors that include the GltPh aspartate transporter, LeuT leucine transporter and two eukaryotic ligand-gated ion channels for which there is currently no high resolution structural data. We aim to carry out specific mechanistics studies on GltPh and LeuT and to perform MAD (SeMet) experiments on the two ligand-gated ion channel proteins in order to solve the phase problem.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 我们的晶体具有多个积分膜蛋白转运蛋白和配体门控的离子通道受体，其中包括GLTPH天冬氨酸转运蛋白，Leut Leucine Transporter和两个真核生物配方配置的离子通道，目前没有高分辨率结构数据。 我们旨在对GLTPH和LEUT进行特定的机构研究，并对两个配体门控离子通道蛋白进行MAD（SEMET）实验，以解决相位问题。