BARDGETT POST-DOC/TECHNICIAN SUPPORT

BARDGETT 博士后/技术员支持

• 批准号: 8168278
• 负责人: MARK Edward BARDGETT
• 金额: $ 6.71万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8168278
• 关键词: Adult; Award; Behavioral; Cognitive; Computer Retrieval of Information on Scientific Projects Database; Data; Dorsal; Funding; Goals; Grant; Hippocampus (Brain); Histamine H3 Receptors; Infusion procedures; Injury; Institution; Memory; Memory impairment; Modeling; Mollies; Motor Activity; N-Methyl-D-Aspartate Receptors; N-Methylaspartate; Neonatal; Paper; Pharmaceutical Preparations; Postdoctoral Fellow; Prefrontal Cortex; Publishing; Rattus; Request for Applications; Research; Research Personnel; Resources; Short-Term Memory; Source; United States National Institutes of Health; improved; prepulse inhibition

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of the proposed research is to develop and use models of modest excitotoxic hippocampal injury to assess the cognitive enhancing ability of specific candidate compounds. Our preliminary data demonstrate that excitotoxic injury to the dorsal hippocampus produces enduring deficits in spatial working memory. We have also shown in preliminary studies that antagonists at histamine H3 receptors alleviate injury-induced deficits in spatial working memory. The specific aims of our currently-funded R15 research have been to answer the following questions: 1) Can H3 antagonists alleviate spatial working memory deficits in rats with adult-onset hippocampal injury, 2) Can direct infusion of H3 antagonists into the prefrontal cortex improve memory in rats with adult-onset hippocampal injury, & 3) Can H3 antagonists alleviate changes in spatial working memory, prepulse inhibition, and locomotor activity in rats with neonatal-onset hippocampal injury? For this application, we requested INBRE supplemental support for a research associate who can advance the aims of our R15 research and supervise undergraduate research. Between May 2009 and the present, we have assessed the effects of H3 antagonists on spatial memory deficits and other behavioral anomalies produced by drugs that block NMDA receptors. These studies, mainly performed by Molly Griffith, our research associate, and several undergraduates in the lab, have shown that H3 antagonists exacerbate the effects of NMDA antagonists on locomotor activity, but also alleviate the spatial memory deficits produced by such drugs. We submitted an R15 to continue these studies in June 2009 and it received a priority score of 37. We will revise and resubmit this application in February 2010. Having INBRE support for our research associate has greatly facilitated the pace of our R15 research and resulted in two published papers, support for award-winning undergraduate research, and an R15 renewal application that received a favorable (although unfundable) score.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 拟议的研究的目的是开发和使用适度的兴奋性海马损伤模型，以评估特定候选化合物的认知增强能力。我们的初步数据表明，背侧海马的兴奋性损伤会导致空间工作记忆的持久缺陷。我们还在初步研究中表明，组胺H3受体的拮抗剂减轻了损伤引起的空间工作记忆缺陷。我们目前资助的R15研究的具体目的是回答以下问题：1）H3拮抗剂可以减轻患有成人海马损伤的大鼠的空间工作记忆缺陷，2）2）2）可以将H3拮抗剂直接输注到前额叶的皮质中，以改善大鼠对成人型海马型Hippocamal unight and them and Hippogocamal and＆3 33）的能力，并可以使33剂及33剂及33剂及33剂的变化。抑制作用和新生儿发作海马损伤大鼠的运动活性？对于此应用，我们要求对可以提高R15研究和监督本科研究目标的研究助理的INBRE补充支持。在2009年5月至现在之间，我们评估了H3拮抗剂对阻断NMDA受体的药物产生的空间记忆缺陷和其他行为异常的影响。这些研究主要由我们的研究助理莫莉·格里菲斯（Molly Griffith）和实验室中的几个大学生进行，表明H3拮抗剂加剧了NMDA拮抗剂对运动活性的影响，但也减轻了这种药物产生的空间记忆缺陷。我们提交了R15在2009年6月继续进行这些研究，并获得了37的优先级评分。我们将在2010年2月进行修订和重新提交此申请。在对我们的研究合作伙伴的inbre支持方面，我们的R15研究的步伐极大地促进了我们的R15研究的节奏，并导致了两份已发表的论文，对屡获殊荣的不足的研究申请书（R15 RENAL）得到了良好的分数（虽然得到了一个良好的分数），并获得了一个RENEW RELEW RENER，这是一项良好的研究。