Tissue/Pathology Core

组织/病理学核心

• 批准号: 7727558
• 负责人: LAWRENCE S LAMB
• 金额: $ 23.15万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7727558
• 关键词: Address; Alabama; Aliquot; Biological; Biometry; Blood; Cataloging; Catalogs; Cells; Cervical; Cervix Uteri; Cervix carcinoma; Clinical; Clinical Trials; Collection; Colorado; Comprehensive Cancer Center; Confidentiality; Core Facility; Databases; Development; Diagnostic Services; Enrollment; Ensure; Epidemiologic Studies; Evaluation; Fees; Funding; Goals; Head and neck structure; Histologic; Human; Human Papillomavirus; Immunohistochemistry; Immunology; Immunology procedure; Immunophenotyping; In Situ Hybridization; Individual; Informed Consent; Laboratories; Lesion; Liquid substance; Location; Malignant neoplasm of cervix uteri; Mission; Normal tissue morphology; Online Systems; Pathologic; Pathology; Patient Care; Patients; Peripheral Blood Mononuclear Cell; Plasma; Practice Guidelines; Premalignant; Process; Quality Control; Reproduction spores; Research; Research Personnel; Resource Sharing; Route; Sampling; Secure; Services; Site; Specimen; Staging; Staining method; Stains; System; Testing; Tissue Microarray; Tissues; Translational Research; Universities; Whole Blood; abstracting; anticancer research; base; cost; data management; design; human tissue; laser capture microdissection; malignant breast neoplasm; neoplastic; programs; tissue preparation; web-enabled

This Tissue/Pathology Core provides well-characterized human biological specimens to researchers participating in this Cervical Cancer SPORE and other collaborative research efforts. In the first funding period this core collected over 78,000 individual aliquots from over 3524 patients enrolled by the SPORE in Cervical Cancer and distributed 6332 aliquots to date. This includes over 28,000 aliquots from 838 patients to date from a clinical trial and two epidemiologic studies of the JHU Breast Cancer and Head and Neck SPOREs at no additional cost. In addition to the growing need for sophisticated sample acquisition, our investigators depend on expert pathology support to ensure proper tissue preparation and characterization for selected studies. This Core provides such expert pathologic evaluation of specimens and technical support. Specifically, this core continues to: 1. Obtain informed consent and collect specimens from patients for translational research without compromise of patient care or confidentiality; 2. Collect cervical carcinoma and pre-malignant lesions, as well as normal tissue from patients, including those enrolled in clinical trials for the SPORE projects; 3. Collect blood, secretions and exfoliated cells (e.g. cervical scrapes) from patients, including those enrolled in clinical trials for the SPORE projects; 4. Process and store clinical specimens following SOPs to address the requirements of all SPORE investigators; 5. Input specimen information into central database system and track specimen distribution and transport; 6. Characterize tissue specimens with respect to site of origin, pathologic grading and staging, and proportion of neoplastic and stromal tissue; 7. Use well-defined mechanisms for prioritization of the distribution of requested specimens to investigators within and external to the Johns Hopkins SPORE; 8. Provide quality-controlled specimens in a timely fashion as inexpensively and efficiently as possible; 9. Route specimens for histologic and virologic analyses e.g. immunohistochemical staining, in situ hybridization, tissue microarraying, and HPV testing and typing, immunophenotyping, or laser-capture microdissection in fee-per-service Comprehensive Cancer Center core facilities; 10. Support the development and implementation of immunologic assays. The samples will be tracked using CaTissue, a CaBIG complaint database, web-enabled for access by our projects at UAB and UC. The activities of this Core will be integrated with those of the Administrative/Clinical Core A, the Biostatistics and Data Management Core B and the Immunology Core D to ensure that specimens and clinical information are appropriately catalogued and disseminated.

该组织/病理学核心为研究人员提供了充分的人类生物标本 参加这项宫颈癌孢子和其他合作研究工作。在第一个资金中 该核心收集了超过3524名孢子中3524名患者的78,000个单独的等分试样 迄今为止，宫颈癌和分布6332个等分试样。这包括来自838名患者的28,000多个等分试样 迄今为止，来自JHU乳腺癌和头颈的两项临床试验和两项流行病学研究 孢子无需额外费用。除了对复杂样本采集的需求不断增长之外，我们的 研究人员依靠专家病理支持以确保适当的组织准备和表征 用于选定的研究。该核心提供了标本和技术的专家病理评估 支持。具体而言，该核心继续：1。获得知情同意并从患者那里收集标本 不妥协患者护理或机密性，进行翻译研究； 2。收集宫颈癌 和恶性病变以及患者的正常组织，包括参加临床试验的病变 孢子项目； 3。从患者那里收集血液，分泌和去角质细胞（例如宫颈刮）， 包括参加孢子项目临床试验的人； 4。过程和存储临床标本 按照SOP解决所有孢子调查人员的要求； 5。输入标本信息 中央数据库系统和跟踪样品分布和运输； 6。表征组织标本 关于起源部位，病理分级和分期，以及肿瘤和基质组织的比例； 7.使用明确定义的机制来优先考虑向研究人员的要求的标本分布 约翰·霍普金斯孢子的内部和外部； 8。及时提供质量控制的标本 尽可能廉价和高效； 9。组织学和病毒学分析的路线标本，例如 免疫组织化学染色，原位杂交，组织微阵列以及HPV测试和分类， 免疫表型，或每次服务全面癌症中心核心的激光捕获显微解剖 设施; 10。支持免疫学测定的开发和实施。样品将是 使用CATISSUE，CABIG投诉数据库进行跟踪，我们的项目在UAB和 UC。该核心的活动将与行政/临床核心A的活动集成在一起 生物统计学和数据管理核心B和免疫学核心D，以确保标本和 临床信息被适当分类和传播。