Design of Novel Opiod Peptide Ligands With Unique Biological Profiles

具有独特生物学特征的新型阿片肽配体的设计

• 批准号: 7513577
• 负责人: Victor J Hruby
• 金额: $ 17.23万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7513577
• 关键词: Absence of pain sensation; Address; Adverse effects; Agonist; Amino Acids; Analgesics; Behavioral; Binding; Biochemical; Biological; Blood - brain barrier anatomy; CALCA gene; Calcitonin Gene-Related Peptide; Calcitonin-Gene Related Peptide Receptor; Cells; Chimera organism; Clinical Medicine; Collaborations; Computer Assisted; Computer-Aided Design; Coupled; Dependence; Dependency; Development; Dipeptides; Dose; Drug abuse; Enkephalins; Equilibrium; Evaluation; Financial cost; G-Protein-Coupled Receptors; Goals; Human; Individual; Investigation; Label; Lead; Ligands; Link; Medical; Medicine; Membrane; Methods; Modality; Modeling; Molecular Conformation; Opioid; Opioid Peptide; Opioid Receptor; Pain; Pain Threshold; Pathway interactions; Penetration; Peptides; Pharmaceutical Preparations; Prodrugs; Property; Purpose; Radiolabeled; Research Project Grants; Roentgen Rays; S100A12 gene; Scientist; Second Messenger Systems; Side; Societies; Spectrum Analysis; Structure; Substance P; Substance P Receptor; Thinking; Time; Toxic effect; Ventilatory Depression; addiction; analog; biphalin; delta opioid receptor; deltorphin; design; drug of abuse; human S100A12 protein; insight; mimetics; mu opioid receptors; novel; novel strategies; painful neuropathy; peptidomimetics; pharmacophore; planetary Atmosphere; radiotracer; receptor; second messenger; tool