Nanogold-Enhanced Radiosurgery for Malignant Brain Tumors

纳米金增强放射外科治疗恶性脑肿瘤

基本信息

批准号：
7480724
负责人：
James F Hainfeld
金额：
$ 17.14万
依托单位：
NANOPROBES, INC.
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-07-01 至 2011-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7480724
关键词：
Angiotensin II Animal Testing Animals Biodistribution Biological Assay Blood Brain Neoplasms Breast Carcinoma Caliber Canis familiaris Carcinoma Clinical Trials Condition Diffusion Dose Drug or chemical Tissue Distribution Effectiveness Female Glioma Gold Human Hybrids Image Immunotherapy Implant Infusion procedures Left Malignant - descriptor Malignant Glioma Malignant Neoplasms Malignant neoplasm of brain Measures Mediating Metals Modeling Mus Normal tissue morphology Pharmaceutical Preparations Positioning Attribute Procedures Public Health Radiosurgery Rattus Recurrence Roentgen Rays Safety Testing Therapeutic Thigh structure Transgenic Organisms Transplantation Tumor Burden Tumor-Associated Vasculature Weight brain tissue day experience follow-up image guided therapy improved intravenous administration irradiation nanoGold nanoparticle outcome forecast photoactivation success treatment planning tumor uptake v-src Oncogenes

项目摘要

DESCRIPTION (provided by applicant): This proposal builds on the unprecedented success achieved by our earlier studies in safely ablating malignant EMT-6 carcinomas in the thighs of mice by using photoactivation radiosurgery mediated by gold nanoparticles (so-called metal-enhanced radiosurgery [MERS]). MERS will be tested for its safety and efficacy in palliating imminently lethal brain tumors [transgenic v-src malignant gliomas] in mice. As the latter is a neuropathologically documented murine model of human malignant gliomas, it is expected that the proposed study will quickly and economically test the postulate that MERS shows promise to contribute to the palliation of some recurrent human gliomas by greatly decreasing the brain tumor burden, thereby enhancing the effectiveness of adjunct drugs and immunotherapies. Tested positive in mice, positive follow-up tests in rats bearing malignant gliomas and satisfactory normal-tissue tolerance tests in fewer large animals (e.g., dogs) would then enable MERS to be brought to clinical trials. PUBLIC HEALTH RELEVANCE: Malignant brain tumors have poor prognoses and new treatments are needed. Here we present a new treatment using gold nanoparticles that enables image guidance of focused irradiation and even magnification of the dose to malignant brain tumors which, if successful, could significantly improve survival.

描述（由申请人提供）：该提案建立在我们早期在小鼠大腿上安全消灭恶性EMT-6癌所取得的前所未有的成功。 MERS将在小鼠中的姑息碰撞致死性脑肿瘤[转基因V-SRC恶性神经胶质瘤]中的安全性和功效。由于后者是人类恶性神经胶质瘤的神经病理学记录的鼠模型，因此拟议的研究将在经济上快速，经济地测试MERS表现出的假设有望通过大大减少脑部肿瘤负担来减轻一些复发性人类神经胶质瘤，从而增强辅助药物和免疫功能。在小鼠中测试的阳性，在带有恶性神经胶质瘤的大鼠中进行阳性随访测试，并令人满意的正常动物耐受性测试在较少的大型动物（例如狗）中将使MERS能够进行临床试验。公共卫生相关性：恶性脑肿瘤的预后不良，需要新的治疗方法。在这里，我们提出了一种使用金纳米颗粒的新处理方法，该治疗方法能够对聚焦辐射，甚至可以放大剂量的图像指导，以使脑肿瘤具有恶性脑肿瘤，如果成功，可以显着提高生存率。