Molecular Mammography of Her-2 Cancers using Gold Nanoparticles

使用金纳米粒子对 Her-2 癌症进行分子乳房 X 线摄影

• 批准号: 7219631
• 负责人: James F Hainfeld
• 金额: $ 17.98万
• 依托单位: NANOPROBES, INC.
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-26 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7219631
• 关键词: breast neoplasms; gold; mammography; neoplasm /cancer

DESCRIPTION (provided by applicant): Cancer imaging is important for tumor detection, determination of prognosis and treatments, image guided surgery and irradiation, as well as for monitoring responses. Molecular imaging of specific targets could identify tumor types and enable selection of appropriate drugs. Although x-ray imaging is widely used and more rapid with higher resolution compared to PET, SPECT, and MRI, there are currently no targeted x-ray contrast agents. In this proposal we will develop molecular targeted agents for mammography by a nanotechnology approach using gold nanoparticles for imaging cancers. The Her 2 protein on breast cancer cells will be targeted by use of antibodies attached to biocompatible gold nanoparticles using a mouse model. This would then be useful for non-invasive in vivo detection of this mutation which occurs in about 30% of human breast cancers that could then be beneficially treated with the monoclonal antibody Herceptin(r). Molecular mammography imaging would improve on the limited sampling afforded by painful biopsies and provide more thorough detection of even small tumors and metastases missed by biopsies and other methods. It would enable earlier detection of breast cancer. Better tumor definition would also improve precise radiotherapy, surgery, and follow-up monitoring. If successful, this technology could be applied to other tumors for early detection and biochemical typing for more effective individualized treatments. To Public Health: A novel method using nanotechnology will be developed for improved non-invasive imaging and detection of breast cancer types by mammography. This should not only enable better early detection of smaller tumors and metastases without painful biopsies, but identify tumor types so that specific drugs for the type can be administered. Such a need exists to detect Her2 breast cancers, which account for about 30% of breast cancers, where the specific drug Herceptin(r) is available and improves survival.

描述（由申请人提供）：癌症成像对于肿瘤检测，预后和治疗方法的测定，图像引导性手术和照射以及监测反应很重要。特定靶标的分子成像可以鉴定肿瘤类型，并可以选择适当的药物。尽管与PET，SPECT和MRI相比，X射线成像被广泛使用，并且具有更高的分辨率，但目前尚无靶向X射线对比剂。在此提案中，我们将通过使用金纳米颗粒进行成像癌的纳米技术方法开发分子靶向剂来进行乳房X线摄影。通过使用小鼠模型使用与生物相容性金纳米颗粒相连的抗体，她的2蛋白在乳腺癌细胞上的目标是靶向。然后，这对于无创的体内检测该突变将很有用，该突变发生在大约30％的人类乳腺癌中，然后可以用单克隆抗体赫赛汀（R）进行实物治疗。分子乳房X线摄影成像将改善疼痛活检提供的有限抽样，并更彻底地检测到活检和其他方法所遗漏的小肿瘤和转移。它将能够早期检测到乳腺癌。更好的肿瘤定义还可以改善精确的放射疗法，手术和随访监测。如果成功的话，该技术可以应用于其他肿瘤，以进行早期检测和生化分型，以进行更有效的个性化处理。公共卫生：将开发一种使用纳米技术的新方法，以改善乳腺X线摄影对乳腺癌类型的检测。这不仅应该使得没有疼痛活检的较小肿瘤和转移的早期检测，而且还应识别肿瘤类型，以便可以施用该类型的特定药物。存在这种需求来检测HER2乳腺癌，该癌症约占乳腺癌的30％，其中特定的药物Herceptin（R）可用并提高了生存。