Detector Module for Portable PET Scanner

用于便携式 PET 扫描仪的探测器模块

• 批准号: 7539124
• 负责人: FARHAD DAGHIGHIAN
• 金额: $ 11.2万
• 依托单位: INTRA MEDICAL IMAGING, LLC
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-14 至 2008-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7539124
• 关键词: Accident and Emergency department; Anatomy; Area; Back; Biopsy; Breast; Caliber; Ceramics; Chest; Clinical; Collection; Condition; Count; Coupled; Decompression Sickness; Depth; Dimensions; Elements; Event; Excision; Facility Construction Funding Category; Figs - dietary; Functional Imaging; Generations; Goals; Head; Head and neck structure; Helmet; Image; Light; Magnetic Resonance Imaging; Malignant Neoplasms; Manuscripts; Mechanics; Neck; Nipples; Operating Rooms; Operative Surgical Procedures; Organ; Patients; Patients' Rooms; Phase; Positioning Attribute; Positron-Emission Tomography; Radial; Resolution; Series; Side; Silicon; Surgeon; System; Thick; Thinness; Time; Title; Ultrasonic Transducer; Ultrasonography; Upper arm; Wireless Technology; base; data acquisition; design; desire; detector; improved; light weight; millimeter; novel; quantum; research study; response; sensor; simulation; size; solid state; tomography; tumor; voltage; whole body imaging

DESCRIPTION (provided by applicant): We will design and evaluate a novel detector module for PET, and demonstrate that it would significantly increase the sensitivity and resolution, while making PET compact, light weight, and portable. The basic detector element proposed is based on the use of a novel light-detector called Solid State Photo- multiplier (SSPM) and LYSO scintillation crystals. Hamamatsu has developed a special ceramic-mounted SSPM for our company. Its compact size (2.4x1.9x0.85 mm) enables construction of PET scanners with a resolution close to a millimeter. Its thinness (0.85 mm) allows multiple layer of the detectors to be put in radial direction enabling the depth of interaction and inter-crystal scatter events. The specific aims of the Phase I of this project are to study, both through simulation as well as experiments with a variety of detector arrangements, the degree of improvements in: 1)- Spatial resolution, 2)- Sensitivity, 3)- Inter-crystal scatter correction, 4)- Depth of interaction identification, 5)- Scatter events rejection 6)- Singles rejection by improved time resolution. The experiments and simulations planned for the Phase I are directed to enable us to build the optimum detector configurations for the Phase II. Significance: Accurate intra-operative tumor localization is critical in a variety of clinical conditions. The ability to adapt PET to the operating room would allow for the generation of real time functional images of tumors , allowing for better tumor localization. The same detector module can be the basis of other larger configurations of portable PET, greatly expanding the application of PET in a variety of settings.

描述（由申请人提供）：我们将设计和评估PET的新型检测器模块，并证明它将显着提高灵敏度和分辨率，同时使PET紧凑，轻巧和便携。提出的基本检测器元件是基于使用一种称为固态光乘数（SSPM）和极度闪烁晶体的新型光检测器的使用。 Hamamatsu已为我们公司开发了一种特殊的陶瓷安装式SSPM。它的紧凑型尺寸（2.4x1.9x0.85毫米）使得在接近毫米的分辨率的宠物扫描仪中构建。它的薄度（0.85 mm）允许将多层检测器放置在径向方向上，从而实现相互作用和晶间散射事件的深度。该项目第一阶段的具体目的是通过模拟以及各种检测器排列的实验，改进的程度：1） - 空间分辨率，2） - 敏感性，3） - 晶体间散射校正，4） - 交互作用识别的消耗，5） - 5） - 散射事件拒绝6） - 单曲线的分辨时间 - 单曲线分辨时间分辨率分辨率分辨出了分辨时间分辨率。计划针对I期的实验和模拟，以使我们能够为II期构建最佳检测器配置。意义：在多种临床条件下，准确的术中肿瘤定位至关重要。将宠物适应手术室的能力将允许产生肿瘤的实时功能图像，从而可以更好地定位肿瘤。相同的检测器模块可以是便携式PET的其他较大配置的基础，从而大大扩展了PET在各种设置中的应用。