Chronic Inflammation and Mindfulness Intervention

慢性炎症和正念干预

• 批准号: 7384931
• 负责人: WILLIAM B. MALARKEY
• 金额: $ 30万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7384931
• 关键词: Acute; Adherence; Adult; Aging; Anxiety; Behavior; Biological; Biological Markers; Blinded; Blood; C-reactive protein; Cardiovascular Diseases; Chronic; Chronic stress; Commit; Condition; Control Groups; Daily; Disease; Dose; Education; End Point; Epidemic; Evaluation; Event; Faculty; Family; Future; Gender; Health; Health behavior; Homeostasis; Hour; Hydrocortisone; Individual; Inflammation; Inflammatory; Instruction; Interleukin-6; Intervention; Life Style; Measures; Medical; Meditation; Mental Depression; Methods; Modeling; Ohio; Outcome; Participant; Patient Self-Report; Physiological; Protein C; Protocols documentation; Public Health; Publishing; Questionnaires; Randomized; Recovery; Recruitment Activity; Research; Residual state; Risk Factors; Role; Saliva; Salivary; Sampling; Score; Sleep; Societies; Standards of Weights and Measures; Stress; Stressful Event; Structure; Subgroup; Target Populations; Testing; Time; Training; Universities; Week; Work; aged; body-mind; computerized; cost; day; depressive symptoms; design; diaries; emotion regulation; experience; improved; instructor; instrument; mindfulness-based stress reduction; pilot trial; programs; psychologic; psychological outcomes; size; trend

DESCRIPTION (provided by applicant): Increasing evidence suggests that chronic stress in our society is a contributing factor to the behaviors and risk factors that have accelerated the increase in numerous disease states. We propose to evaluate the influence of a modified mindfulness-based stress reduction (MBSR-ld) to decrease biologic markers of stress and chronic inflammation which are risk factors for the diseases of aging. Participants will be selected with upper tertile values of the inflammatory marker C-reactive protein (CRP), a risk factor for cardiovascular disease. We will use a two group single blinded randomized parallel design to assess the effect of MBSR-ld on psychological, biological and resiliency measures among subjects aged 35-60 years. We will compare 90 subjects on this program with 90 subjects from a lifestyle education control group without mindfulness training. Prior to randomization, a two week computerized daily diary program designed to evaluate stress and resiliency (recovery of homeostasis following stressful events) will be administered for two weeks before and after the intervention. During the diary weeks salivary cortisol will be obtained (4 times throughout the day) to provide a physiologic stress measure. The subjects will then be randomized to a control or mindfulness group. They will be blinded as to the content of the other stress reduction program. The MBSR-ld and lifestyle education participants will involve one hour of instruction weekly and 20 minutes of mindfulness or lifestyle education practice daily for 8 weeks. Both groups will receive questionnaires evaluating perceived stress, sleep quality, anxiety, depression, and mindfulness, as well as blood work for stress and inflammatory markers at baseline and 2 months after the interventions. The two week diaries and weekly cortisol sampling will be repeated 2 months post intervention. The primary specific aim of this proposal is to determine if MBSR-ld can produce greater decreases in biologic measures of chronic inflammation and stress (CRP, IL-6 and cortisol) when compared to a standard stress reduction protocol. A secondary specific aim is to determine if MBSR-ld can better improve measures of mindfulness, resiliency, perceived stress, sleep quality, anxiety and depressive symptoms when compared to a lifestyle education protocol. Public Health Relevance: In spite of recent medical advances, the US is experiencing epidemics of various chronic medical conditions. Stressful lifestyle and poor health behaviors are major contributors to this health crisis. We will examine the role of mindfulness meditation, a relatively low cost program, in reducing biologic markers of stress and inflammation which are risk factors for the diseases of aging.

描述（由申请人提供）：越来越多的证据表明，我们社会中的慢性压力是导致许多疾病状态增加的行为和风险因素的因素。我们建议评估基于正念的压力减轻（MBSR-LD）的影响，以减少压力和慢性炎症的生物学标志物，这是衰老疾病的危险因素。将选择参与者的炎症标记C反应蛋白（CRP）的上三位数值，这是心血管疾病的危险因素。我们将使用两组单盲随机平行设计来评估MBSR-LD对35-60岁受试者的心理，生物学和弹性指标的影响。我们将在没有正念培训的情况下将该计划中的90个主题与来自生活方式教育控制小组的90个主题进行比较。在随机分组之前，将在干预之前和之后进行两周计算机化的每日日记计划（旨在评估压力事件发生后的压力和稳态恢复）（压力事件后的稳态恢复）。在日记内，将获得唾液皮质醇（全天4次），以提供生理胁迫度量。然后，受试者将被随机分为对照或正念组。他们将对其他减少压力计划的内容蒙蔽。 MBSR-LD和生活方式教育参与者将每天进行一小时的教学和20分钟的正念或生活方式教育练习，持续8周。这两组将收到评估压力，睡眠质量，焦虑，抑郁和正念的问卷，以及在基线和干预后2个月的压力和炎症标记的血液工作。干预后2个月将重复两周的日记和每周皮质醇抽样。 该提案的主要目的是确定MBSR-LD是否可以在慢性炎症和应激的生物学测量中产生更大的降低（CRP，IL-6和皮质醇）与标准应力减少方案相比。次要的特定目的是确定与生活方式教育方案相比，MBSR-LD是否可以更好地改善正念，弹性，感知压力，睡眠质量，焦虑和抑郁症状的度量。 公共卫生相关性：尽管最近进步，美国仍在经历各种慢性医疗状况的流行病。 压力很大的生活方式和健康行为不良是造成这种健康危机的主要贡献者。我们将研究正念冥想的作用，即相对较低的成本计划，在减少压力和炎症的生物学标记中，这是衰老疾病的危险因素。