Urban Diesel Exposure and Inner City Asthma

城市柴油暴露和内城哮喘

• 批准号: 7254865
• 负责人: RACHEL L MILLER
• 金额: $ 61.69万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-16 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7254865
• 关键词: Adolescent; African American; Age; Air Pollutants; Air Pollution; Allergens; Allergic; Antigens; Area; Asthma; Birth; Carbon; Carbon Black; Child; Childhood Asthma; Data; Development; Diagnosis; Diesel Exhaust; Dominican; Environmental Exposure; Environmental Health; Environmental Tobacco Smoke; Exposure to; Goals; Health; Home environment; Hypersensitivity; Hypersensitivity skin testing; IgE; Intervention; Lead; Life; Lung; Malignant Neoplasms; Measurement; Measures; Medical Research; Monitor; New York; Outcome; Particulate Matter; Pollen; Protocols documentation; Recruitment Activity; Relative (related person); Reporting; Respiratory physiology; Risk; Serum; Symptoms; T-Cell Proliferation; Third Pregnancy Trimester; Trace metal; Urine; Week; air monitoring; atopy; base; cohort; inner city; member; pulmonary function; respiratory; trafficking

DESCRIPTION (provided by applicant): Living in areas with high volumes of motorized traffic has been associated with respiratory symptoms and deceased lung function in children. Based on both these epidemiological findings and supporting experimental data, exposure to diesel-related air pollution has potential for health concerns that include asthma and allergy. However, despite substantial gains in our recognition of likely diesel-induced asthmatic or allergic symptoms, direct associations between exposure to diesel-related air pollution and the onset of atopy and asthma in young children have not yet been demonstrated. The interaction of diesel exposure with other urban exposures on respiratory health also is not clear. We hypothesize that exposure to diesel emissions in Northern Manhattan and the South Bronx is associated with allergen-specific sensitization, decreased lung function, and the onset of asthma in children at age 5 through 6 years. Our strategy is to take advantage of an established inner city birth cohort in which multiple environmental exposures and health outcomes already are being measured to evaluate whether exposure to diesel-related air pollution independently, or jointly with other prevalent urban environmental exposures (allergens, environmental tobacco smoke [ETS]), increase the risk for the onset of atopy or asthma. Specifically, we propose to use our established cohort to: Aim 1. Determine whether exposure to diesel-related air pollution is associated with the onset of allergen-specific sensitization, decreased lung function and/or asthma at age 5 through 6 years, and Aim 2. Determine whether exposure to diesel-related air pollution interacts with a) allergen, and/or b) ETS exposure, on the onset of allergen-specific sensitization, decreased lung function and/or asthma at age 5-6 years. 300 Dominican and African American children residing in Northern Manhattan that are being followed prospectively since birth as part of Columbia Center for Children's Environmental Health will be recruited at age 5 through 6 years. Two-week air monitoring at home for PAHs, black carbon, mass, and trace metals will be performed. Repeat measures of PM25 and carbon will be repeated 6 months later. Outcomes include sera IgE, antigen-specific T cell proliferation, allergy skin tests, lung function, and asthma diagnosis. The primary goals are to determine whether diesel-related exposure can induce the development of allergy and/or asthma, and to identify its contribution relative to other urban exposures.

描述（由申请人提供）：生活在机动交通繁忙的地区与儿童呼吸道症状和肺功能下降有关。根据这些流行病学发现和支持实验数据，接触与柴油相关的空气污染可能会导致哮喘和过敏等健康问题。然而，尽管我们对可能由柴油引起的哮喘或过敏症状的认识取得了实质性进展，但接触柴油相关空气污染与幼儿特应性和哮喘发作之间的直接关系尚未得到证实。柴油暴露与其他城市暴露对呼吸系统健康的相互作用也尚不清楚。我们假设，曼哈顿北部和布朗克斯南部接触柴油排放与 5 至 6 岁儿童的过敏原特异性致敏、肺功能下降和哮喘发作有关。我们的策略是利用已建立的内城出生队列，其中已经测量了多种环境暴露和健康结果，以评估是否单独暴露于柴油相关的空气污染，或与其他普遍的城市环境暴露（过敏原、环境烟草）一起评估吸烟[ETS]），增加特应性或哮喘发作的风险。具体来说，我们建议利用我们已建立的队列来： 目标 1. 确定接触与柴油相关的空气污染是否与 5 至 6 岁时过敏原特异性过敏、肺功能下降和/或哮喘的发生有关，以及 目标 2. 确定在 5-6 岁出现过敏原特异性致敏、肺功能下降和/或哮喘时，暴露于柴油相关空气污染是否与 a) 过敏原和/或 b) ETS 暴露相互作用。 哥伦比亚儿童环境健康中心将招募 300 名居住在曼哈顿北部的多米尼加和非裔美国儿童，这些儿童从出生起就受到前瞻性跟踪，这些儿童将在 5 至 6 岁时被招募。将进行为期两周的家庭空气监测，以检测多环芳烃、黑碳、质量和痕量金属。 PM25 和碳的重复测量将在 6 个月后重复进行。结果包括血清 IgE、抗原特异性 T 细胞增殖、过敏皮肤测试、肺功能和哮喘诊断。主要目标是确定与柴油相关的接触是否会诱发过敏和/或哮喘，并确定其相对于其他城市接触的贡献。