Neighborhoods, Women and Coronary Heart Disease: A Prospective Study

社区、妇女和冠心病：一项前瞻性研究

• 批准号: 7617952
• 负责人: Chloe E. Bird
• 金额: $ 79.09万
• 依托单位: RAND CORPORATION
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7617952
• 关键词: Address; Affect; Age; Age of Onset; Behavioral; Biological; Cardiac; Cardiovascular system; Cause of Death; Censuses; Centers for Population Health; Cessation of life; Characteristics; Clinical; Clinical Trials; Coronary heart disease; Coupled; Data; Development; Disease Outcome; Elderly woman; Environment; Environmental Risk Factor; Epidemiology; Event; Exercise; Gender; Genetic; Health; Health Benefit; Health Status; Health behavior; Incidence; Income; Individual; Intervention; Libraries; Life; Link; Literature; Measurement; Measures; Mediating; Modeling; Monitor; Neighborhoods; Observational Study; Outcome; Pathway interactions; Pattern; Policies; Pollution; Poverty; Prospective Studies; Public Policy; Research; Resources; Risk; Risk Factors; Scientist; Skin; Social Characteristics; Social Environment; Social support; Source; Study Subject; Testing; United States; Upper arm; Well in self; Woman; Women' s Health; behavioral health; cardiovascular disorder risk; cohort; contextual factors; depression; design; health disparity; heart disease risk; improved; innovation; men; middle age; social; suburb

DESCRIPTION (provided by applicant): Although research suggests that where one lives affects one's risk of coronary heart disease (CHD), scientists have only begun to explore the pathways through which neighborhoods "get under the skin." Recent studies demonstrate that the built environment affects individual health and health behaviors, but have not examined the relationship between the built environment and cardiovascular health risk or subsequent cardiac events. Moreover, factors influencing the development and clinical manifestations of CHD differ substantially in women and men, and studies suggest that neighborhood social and built environments also affect men and women differently. The overarching objective of the proposed project is to examine the impact of neighborhood factors on women's development of CHD. We aim to identify aspects of the built environment that can be modified through urban planning or public policy and are associated with health benefits. The project will expand on existing research by investigating both the social and built environment and by examining whether behavioral factors, social relationships, and psychological well-being mediate the links between environmental characteristics and CHD development among women. The specific aims of our 3-year project are: 1. To assess whether built and social characteristics of neighborhoods predict the development of CHD after controlling for baseline sociodemographic and biological measures of CHD risk. 2. To evaluate whether aspects of the built and social environment are associated with individual health behaviors, social support, and psychological well-being that are known to be related to CHD in women. 3. To determine whether pathways between environmental characteristics and CHD are mediated by individual health behaviors, social support, and/or psychological well-being. To address these aims this project brings together two unique resources: individual-level data from the Observational Study (OS) and Clinical Trial (CT) arms of the Women's Health Initiative (WHI), a prospective study of 161,809 women ages 50 to 79 at entry, and geocoded, census-tract level contextual data on the sociodemographic and built environment where study subjects reside derived by the RAND Center for Population Health and Health Disparities (CPHHD) data core from the Census and other sources.

描述（由申请人提供）：尽管研究表明，一个人居住的地方会影响一个人的冠心病风险（CHD），但科学家才开始探索社区“在皮肤下”的途径。最近的研究表明，建筑环境会影响个人的健康和健康行为，但尚未检查建筑环境与心血管健康风险或随后的心脏事件之间的关系。此外，影响冠心病的发展和临床表现的因素在男女中有很大差异，研究表明，邻里社会和建筑环境也对男人和女人的影响也有所不同。拟议项目的总体目标是研究邻里因素对妇女发展冠心病的影响。我们旨在确定可以通过城市规划或公共政策来修改的建筑环境的各个方面，并与健康福利相关。该项目将通过研究社会环境和建筑环境，并检查行为因素，社会关系和心理健康是否介导妇女之间环境特征与冠心病发展之间的联系来扩展现有研究。我们三年项目的具体目的是：1。评估社区的建造和社会特征是否可以预测控制基线社会人口统计学和冠心病风险的生物学测量的冠心病的发展。 2。评估建筑和社会环境的各个方面是否与已知与女性冠心病相关的个人健康行为，社会支持和心理健康。 3。确定环境特征和CHD之间的途径是否是由个人健康行为，社会支持和/或心理健康介导的。 To address these aims this project brings together two unique resources: individual-level data from the Observational Study (OS) and Clinical Trial (CT) arms of the Women's Health Initiative (WHI), a prospective study of 161,809 women ages 50 to 79 at entry, and geocoded, census-tract level contextual data on the sociodemographic and built environment where study subjects reside derived by the RAND Center for Population Health and Health Disparities （CPHHD）来自人口普查和其他来源的数据核心。

项目成果

Use of alternative time scales in Cox proportional hazard models: implications for time-varying environmental exposures.

• DOI: 10.1002/sim.5347
• 发表时间: 2012-11-30
• 期刊: STATISTICS IN MEDICINE
• 影响因子: 2
• 作者: Griffin, Beth Ann;Anderson, Garnet L.;Shih, Regina A.;Whitsel, Eric A.
• 通讯作者: Whitsel, Eric A.