The Unique Bioinorganic Chemistry of the Formation of Hydroxyaluminosilicates: A Case to Support a New Graphite Furnace Atomic Absorption Spectrometer

羟基铝硅酸盐形成的独特生物无机化学：支持新型石墨炉原子吸收光谱仪的案例

• 批准号: EP/G00983X/1
• 负责人: Christopher Exley
• 金额: $ 7.06万
• 依托单位: Keele University
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FG00983X%2F1
• 关键词: Unique; Bioinorganic; Chemistry; Formation; Hydroxyaluminosilicates

Research in the Bioinorganic Chemistry Laboratory at Keele University is focussed upon the biological reactivity, availability and essentiality of the second and third most common elements of the Earth's crust, silicon and aluminium. In particular we have shown that aluminium binds silicon in forming hydroxyaluminosilicates and in doing so protects against the known toxicity of aluminium. It is essential to the continuing success of all of the research that we can measure low concentrations of aluminium accurately and reproducibly and we achieve this using instrumentation called a Graphite Furnace Atomic Absorption Spectrometer (GFAAS). Unfortunately our present machine which was bought in 1992 is no longer serviceable and we urgently require to replace it so that all of our research can continue without delay. In this application we have highlighted the ongoing research in our laboratory which uses GFAAS as well as prospective research and our committments to teaching undergraduate and postgraduate students with the view to demonstrating our need for a new GFAAS. Funds to support the buying of a new GFAAS are the subject of this application.

基尔大学生物无机化学实验室的研究集中在地球，硅和铝的第二和第三常见元素的生物反应性，可用性和本质上。特别是我们已经表明，铝在形成羟基氨基硅硅酸盐中结合了硅，并可以预防已知的铝毒性。对于所有研究的持续成功至关重要，我们可以准确且可重复地测量低浓度的铝，并使用称为石墨炉原子吸收光谱仪（GFAAS）实现这一目标。不幸的是，我们目前在1992年购买的机器不再可用，我们迫切需要替换它，以便我们的所有研究都可以毫不拖延。在此应用程序中，我们强调了我们的实验室正在进行的研究，该研究使用GFAAS以及前瞻性研究以及我们的承诺，教学本科生和研究生，以表明我们需要新的GFAAS。支持购买新GFAA的资金是本申请的主题。

项目成果

New insight into silica deposition in horsetail (Equisetum arvense).

• DOI: 10.1186/1471-2229-11-112
• 发表时间: 2011-07-29
• 期刊: BMC plant biology
• 影响因子: 5.3
• 作者: Law C;Exley C
• 通讯作者: Exley C

There is (still) too much aluminium in infant formulas.

• DOI: 10.1186/1471-2431-10-63
• 发表时间: 2010-08-31
• 期刊: BMC pediatrics
• 影响因子: 2.4
• 作者: Burrell SA;Exley C
• 通讯作者: Exley C

Aluminium in the human brain

• DOI: 10.1007/s00706-010-0417-y
• 发表时间: 2011-04-01
• 期刊: MONATSHEFTE FUR CHEMIE
• 影响因子: 1.8
• 作者: Exley, Christopher;House, Emily R.
• 通讯作者: House, Emily R.