Imaging Core

成像核心

• 批准号: 7480934
• 负责人: James McCracken
• 金额: $ 17.55万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7480934
• 关键词: Algorithms; Architecture; Area; Attention deficit hyperactivity disorder; Behavior Disorders; Behavioral; Biofeedback; Brain; Brain imaging; Child; Childhood; Computer software; Consult; Consultations; Corpus striatum structure; Data; Data Analyses; Data Quality; Databases; Development; Disease; Education; Electronics; Ensure; Environment; Experimental Designs; Feedback; Freedom; Functional Magnetic Resonance Imaging; Future; Gilles de la Tourette syndrome; Goals; Grant; Head; Human; Human Resources; Image; Image Analysis; Imaging technology; Individual; Laboratories; Magnetic Resonance Imaging; Magnetism; Methodology; Methods; Morphologic artifacts; Motion; Neurobiology; Physiologic pulse; Population; Predisposition; Protocols documentation; Pulse taking; Purpose; Quality Control; Recruitment Activity; Research; Research Design; Research Infrastructure; Research Personnel; Resolution; Resources; Scanning; Services; Signal Transduction; Simulate; Solutions; Staging; System; Techniques; Testing; Training; Training Programs; Variant; base; cognitive control; data mining; desensitization; design; developmental disease; experience; feeding; image processing; improved; novel; programs; reconstruction; research study; simulation; software development; tool; user-friendly

The purpose of this core is to provide infrastructure resources for projects in the grant utilizing Magnetic Resonance Imaging, and to develop resources that may be shared for the current projects as well as future projects relevant to developmental disorders in fronto-striatal circuits. There will be four primary components of the Imaging Core: a technical sub-core, focused on testing and ensuring high image quality and integrating new technological developments developments including novel pulse sequences, parallel imaging technology, a head gradient set, rapid reconstruction algorithms, and simultaneous EEG/fMRI,as well as supporting structural MRi and DTI acqiuisition. A design and analysis sub-core will provide expertise for designing and implementing fMRi experiments, and analysis of fMRI, structural MRI and DTI data, and analysis. A behavioral training/desensitization unit will use a simulated MRi environment with biofeedback to desensitization pediatric subjects to the environment and track head motion to maximize the likelihood of successfully scanning difficult populations. Finally, an analysis and databasing unit will conduct fMRI analyses for CIDAR projects and manage and maintain a structural MRI database. Structural and DTI data acquired in the Imaging core will feed into all of the human projects (1,3,and 4) to test specific hypothesis of structural and functional connectivity in front-striatal circuits. The infrastructure resources provided by the Imaging Core is integral to projects 3 and 4 and benefits subjects entering Project 1; these resources will be available for future pediatric imaging studies that may access the UCLA CIDAR in future years. An imaging core dedicated to promoting research into the neurobiology of ADHD and Tourette's will enable us to tackle some of the more difficult problems in pediatric imaging, namely, the technical difficulties in image acquisition in orbito-frontal retgions; analysis of developing brains that may contain structural differences or abnormalities; variability in brain development in children; and practical difficulties in scanning children with disorders of cognitive control. Having core resources at every stage of the imaging study, from design and image acquisition through data analysis, will enable investigators who are not imaging experts to apply these methods to other developmental disorders, and will provide resources to evaluate the effects of new treatments, both behavioral and pharmacological, on brain function in developmental disorders.

该核心的目的是为利用磁性的赠款提供基础设施资源 共振成像，并开发可能为当前项目以及未来共享的资源 与额纹状体电路中发育障碍有关的项目。将有四个主要组件 成像核心：技术子核，专注于测试和确保高图像质量和 整合新的技术发展发展，包括新型脉冲序列，平行成像 技术，头部梯度集，快速重建算法和同时的脑电图/fMRI以及 支持结构MRI和DTI ACQIUISITION。设计和分析子核将为 设计和实施fMRI实验，以及fMRI，结构MRI和DTI数据的分析以及 分析。行为训练/脱敏单元将使用具有生物反馈的模拟MRI环境来 脱敏的儿科受试者对环境并跟踪头部运动，以最大程度地提高 成功扫描困难的人群。最后，分析和数据库单元将进行fMRI 分析CIDAR项目并管理和维护结构性MRI数据库。结构和DTI数据 在成像核心中获得的所有人类项目（1,3和4）都将进食 前纹状体电路中的结构和功能连通性。由 成像核心是项目3和4的组成部分，并且进入项目1的福利主题是不可或缺的。这些资源将是 可用于未来的儿科成像研究，这些研究可能会在未来的几年中访问UCLA CIDAR。成像 致力于促进ADHD和Tourette神经生物学研究的核心将使我们能够解决 小儿成像中一些更困难的问题，即图像获取的技术困难 在Orbito-Frontal Retgions中；分析可能包含结构差异或 异常；儿童大脑发育的变化；以及扫描儿童的实际困难 认知控制的疾病。在成像研究的每个阶段都有核心资源，从设计和 通过数据分析获取图像，将使没有成像专家的调查人员能够应用这些 其他发育障碍的方法，并将提供资源来评估新的效果 行为和药理学的治疗方法在发育障碍中的大脑功能。