CORE--Imaging

核心--成像

• 批准号: 7786050
• 负责人: Louis Dell'ltalia
• 金额: $ 74.05万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7786050
• 关键词: CORE; Imaging

In the current SCCOR, we are attempting to understand the underlying biochemical mechanisms of LV remodeling and, as such, this Core is integral in that it will provide in vivo measurements of LV function and geometry in all SCCOR projects. The state of the art features are brought to bear in both human and animal studies. First, in the human studies we utilize 3-dimensional MR imaging and tissue tagging with state of the art quantitative strain and curvature analysis led by Dr. Denney at Auburn University. This allows for a definitive analysis of changes in geometry and function that is also highly reproducible and, thus, highly amenable to the serial studies. The reproducibility of imaging is crucial for comparisons within and between projects. Therefore, centralization of this and the service it provides are central to the success of the SCCOR. Second, animals will undergo echocardiographic examinations and hemodynamic assessments to obtain LV dimensions, LV end-systolic stress-volume and LV end-diastolic pressure-volume relations. Therefore, centralization of this and the service it provides are central to the success of the SCCOR. One important ultimate goal of Imaging is to generate new insight regarding LV remodeling and function using state of the art three-dimensional magnetic resonance imaging and quantitative strain and curvature analysis that will in turn motivate future novel hypothesis-driven experimental and therapeutic approaches.

在当前的 SCCOR 中，我们正在尝试了解潜在的生化 左心室重塑机制，因此，该核心是不可或缺的，因为它将在体内提供 所有 SCCOR 项目中 LV 功能和几何形状的测量。最先进的功能被应用于人类和动物研究中。首先，在人体研究中，我们利用 3 维 MR 成像和组织标记以及最先进的定量应变和 由奥本大学 Denney 博士领导的曲率分析。这样可以对几何形状和功能的变化进行明确的分析，并且具有高度的可重复性，因此非常适合系列研究。成像的可重复性对于项目内部和项目之间的比较至关重要。因此，它及其提供的服务的集中化是核心 SCCOR 的成功。其次，动物将接受超声心动图检查和血流动力学评估，以获得左心室尺寸、左心室收缩末期应力体积和左心室 舒张末期压力-容积关系。因此，它及其服务的集中化 提供是 SCCOR 成功的核心。成像的一个重要最终目标 是利用最先进的技术对 LV 改造和功能产生新的见解 三维磁共振成像以及定量应变和曲率分析将反过来推动未来新颖的假设驱动的实验和治疗方法。