CORE--Imaging

核心--成像

• 批准号: 7786044
• 负责人: Louis Dell'ltalia
• 金额: $ 71.24万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7786044
• 关键词: bioimaging /biomedical imaging; blood pressure; blood volume; cardiovascular disorder diagnosis; diagnosis quality /standard; echocardiography; heart circulation; heart contraction; heart function; heart imaging /visualization /scanning; heart ventricle; hemodynamics; magnetic resonance imaging; morphology; shear stress; three dimensional imaging /topography

In the current SCCOR, we are attempting to understand the underlying biochemical mechanisms of LV remodeling and, as such, this Core is integral in that it will provide in vivo measurements of LV function and geometry in all SCCOR projects. The state of the art features are brought to bear in both human and animal studies. First, in the human studies we utilize 3-dimensional MR imaging and tissue tagging with state of the art quantitative strain and curvature analysis led by Dr. Denney at Auburn University. This allows for a definitive analysis of changes in geometry and function that is also highly reproducible and, thus, highly amenable to the serial studies. The reproducibility of imaging is crucial for comparisons within and between projects. Therefore, centralization of this and the service it provides are central to the success of the SCCOR. Second, animals will undergo echocardiographic examinations and hemodynamic assessments to obtain LV dimensions, LV end-systolic stress-volume and LV end-diastolic pressure-volume relations. Therefore, centralization of this and the service it provides are central to the success of the SCCOR. One important ultimate goal of Imaging is to generate new insight regarding LV remodeling and function using state of the art three-dimensional magnetic resonance imaging and quantitative strain and curvature analysis that will in turn motivate future novel hypothesis-driven experimental and therapeutic approaches.

在当前的SCCOR中，我们试图了解基本的生化 LV重塑的机理，因此，该核心是不可或缺的，因为它将提供体内 所有SCCOR项目中LV功能和几何形状的测量。在人类和动物研究中，采用最先进的特征。首先，在人类研究中，我们利用3维MR成像和组织标记，并使用最先进的定量菌株和 奥本大学丹尼博士领导的曲率分析。这允许对几何和功能的变化进行明确的分析，这些变化也可以高度重现，因此高度适合串行研究。成像的可重复性对于项目内部和项目之间的比较至关重要。因此，对此的集中化及其提供的服务是核心 为了成功。其次，动物将接受超声心动图检查和血液动力学评估，以获得LV尺寸，LV末端音节应力量和LV 末期压力 - 体积关系。因此，集中化和服务 提供是SCCOR成功的核心。成像的一个重要最终目标 是为了使用艺术状态生成有关LV重塑和功能的新见解 三维磁共振成像以及定量应变和曲率分析将激励未来的新型假设驱动的实验和治疗方法。