Clinical Infrastructure

临床基础设施

• 批准号: 7786010
• 负责人: GARY S FRANCIS
• 金额: $ 56.88万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7786010
• 关键词: Clinical; Infrastructure

The Clinical Infrastructure Core is an indispensable component of the SCCOR proposal. It is the unifying link that serves each Project in a very specific manner by providing blood for DNA analysis and assorted biochemistry determinations. Just as importantly, the Clinical Infrastructure Core collects, collates, files and retrieves all clinical data, thereby matching each scientific analysis to key clinical information. Moreover, the Clinical Infrastructure Core is responsible for recruiting patients, controls, and unique families for longitudinal study. It is also responsible for the systematic follow-up of these patients and their families. In reality, this is an enormous task, requiring the multiple interactions with patients, families, physicians, research nurses, scientists, IRBs and administrators. Thousands of samples will be acquired, stored, retrieved and analyzed. An exceptionally large database of clinical, demographic, angiographic, electrocardiographic and echocardiographic material will be generated and maintained. The group at the Cleveland Clinic has already assembled such an organization on site in the form of GeneBank and GeneQuest. We have now several years of experience with these two large and important data repositories, generously maintained by strong institutional support. We have space and a large cadre of research nurses, computers, technicians and some physicians to operate this labor-intensive infrastructure. Over time, its operational aspects have improved, and important new data on genes and coronary artery disease are currently emerging. We now have an opportunity with the SCCOR to expand our research goals and further link our clinical phenotype information in the data banks to the genetic and molecular pathophysiology of coronary artery disease. The Clinical Infrastructure Core is clearly essential to this end. We believe that under the able leadership of Drs. Gary Francis and Stephen Ellis and our many dedicated personnel, that we can leverage our unique experience with GeneBank and GeneQuest to focus on new and tightly integrated SCCOR projects designed to explore and better understand the genetics of coronary artery disease.

临床基础设施核心是 SCCOR 提案不可或缺的组成部分。它是一个统一的环节，通过提供血液进行 DNA 分析和各种生化测定，以非常具体的方式为每个项目提供服务。同样重要的是，临床基础设施核心收集、整理、归档和检索所有临床数据，从而将每个科学分析与关键临床信息相匹配。此外，临床基础设施核心负责招募患者、对照和独特家庭进行纵向研究。它还负责对这些患者及其家属进行系统随访。事实上，这是一项艰巨的任务，需要与患者、家属、医生、研究护士、科学家、 IRB 和管理员。将采集、存储、检索和分析数千个样本。将生成并维护一个异常庞大的临床、人口统计、血管造影、心电图和超声心动图材料数据库。克利夫兰诊所的团队已经在现场组建了这样一个组织，即 GeneBank 和 GeneQuest。我们现在在这两个大型且重要的数据存储库方面拥有多年的经验，并得到了强有力的机构支持的慷慨维护。我们有空间和大量的研究护士、计算机、技术人员和一些医生来操作这一劳动密集型项目 基础设施。随着时间的推移，其操作方面得到了改善，并且目前正在出现有关基因和冠状动脉疾病的重要新数据。我们现在有机会与 SCCOR 合作扩大我们的研究目标，并进一步将数据库中的临床表型信息与冠状动脉疾病的遗传和分子病理生理学联系起来。为此，临床基础设施核心显然至关重要。我们相信，在博士的干练领导下。加里·弗朗西斯 (Gary Francis) 和斯蒂芬·埃利斯 (Stephen Ellis) 以及我们众多敬业的人员，我们可以利用我们在 GeneBank 和 GeneQuest 方面的独特经验来专注于新的、紧密的合作 综合 SCCOR 项目旨在探索和更好地了解冠状动脉疾病的遗传学。