Congenital CMV Conference: Education, Prevention and Treatment

先天性巨细胞病毒会议：教育、预防和治疗

• 批准号: 7544350
• 负责人: LENORE PALMA PEREIRA
• 金额: $ 0.9万
• 依托单位: PUBLIC HEALTH FOUNDATION ENTERPRISES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7544350
• 关键词: Affect; Area; Awareness; Biology; Blindness; Centers for Disease Control and Prevention (U.S.); Clinical; Communication; Communication impairment; Congenital Abnormality; Cytomegalovirus Infections; Data; Diagnosis; Diagnostic; Diagnostic tests; Disease; Education; Family; Fetal Growth Retardation; Foundations; Friends; Funding; Gifts; Goals; Grant; Hearing; Hearing Impaired Persons; Infant; Infection; Institutes; Italy; Joints; Language; Medical; Mental Retardation; Mothers; National Institute of Allergy and Infectious Disease; National Institute of Child Health and Human Development; Nature; Neonatal; Numbers; Participant; Pathology; Placenta; Policy Maker; Pregnancy; Prevalence; Prevention; Prevention education; Public Health; Published Comment; Range; Request for Applications; Research; Research Personnel; Scientist; Sensorineural Hearing Loss; Societies; Standards of Weights and Measures; Survivors; Therapeutic Intervention; Title; Touch sensation; Translations; Vaccination; Vaccine Therapy; Vaccines; Videotape; Women' s Health; congenital cytomegalovirus; deafness; design; fetal infection; interest; neonate; novel diagnostics; novel vaccines; posters; pregnancy prevention; programs; prospective; success; symposium; therapy development; treatment planning; vaccine development

DESCRIPTION (provided by applicant): Primary cytomegalovirus (CMV) infection affects 1-3% of pregnancies, causing intrauterine growth restriction and permanent birth defects in 25% of congenitally infected babies in mothers with primary infection. Symptomatic infants often succumb in the neonatal period, and most survivors have permanent debilitating sequelae, including mental retardation, vision loss and sensorineural deafness. This application for conference grant funding builds on the success of the first conference entirely devoted to congenital CMV infection held in Orvieto, Italy in 2006. This special conference focuses entirely on congenital CMV infection at all levels from the biology of maternal and fetal infection, pathology in the placenta, diagnostic tests in mother and neonates, treatments during pregnancy and for diseased babies and novel vaccine developments. The specific aims are as follows. First, to organize a program with the highest level of scientific content for the conference. To achieve this standard of excellence, internationally recognized experts at the forefront of their fields will be invited. There is an interesting blend of established investigators who have been leaders in their respective areas for many years and new researchers with cutting edge perspectives on diagnosis, treatment and development of novel vaccines. Second, there is a strong emphasis on research that is highly relevant to important clinical questions and has potential for translation into medical practice. These sessions acknowledge the direct medical relevance of specific research interests of the attendees, as well as the exciting potential for designing new diagnostic tests, intervention therapies and vaccines. Third, there is an important focus on public education and awareness of the prevalence of congenital CMV infection and impact on society. Educational goals will be achieved by including families affected by congenital disease and providing an instructive forum for interested public participants and policy makers. We anticipate this conference will attract participants from various backgrounds ranging from basic and industrial researchers to diagnostic and clinical practitioners. Notably, the principal goal of this conference is to stimulate crossdisciplinary exchange among scientists with diverse interests in congenital CMV infection and integration of new information to educate the public about this long overlooked disease and prospects for treatment during pregnancy and prevention through vaccination.

描述（由申请人提供）：原发性巨细胞病毒（CMV）感染会影响1-3％的妊娠，在原发性感染的母亲中造成25％的先天感染婴儿的宫内生长限制和永久性出生缺陷。有症状的婴儿经常在新生儿时期屈服，大多数幸存者都有永久性的后遗症，包括智力低下，视力丧失和感觉性耳聋。该会议授予资金的申请是基于第一次会议的成功，完全致力于2006年在意大利奥尔维埃托举行的先天性CMV感染。该特别会议完全侧重于各级先天性CMV感染，这些级别的母体和胎儿感染生物学，病理学的生物学，在肥料中的病理学，母亲和新生儿的诊断，诊断，诊断，诊断。 怀孕期间的治疗，患病的婴儿和新型疫苗开发。具体目标如下。首先，组织会议的科学内容最高水平的程序。为了实现这一卓越标准，将邀请国际认可的专家在其领域的最前沿。既定的研究人员都有有趣的融合，他们多年来一直是各自地区的领导者，并且具有对新型疫苗的诊断，治疗和开发的最前沿观点的新研究人员。其次，非常重视与重要临床问题高度相关的研究，并且有可能转化为医学实践。这些会议承认与会者特定研究兴趣的直接医学相关性，以及设计新的诊断测试，干预疗法和疫苗的令人兴奋的潜力。第三，重要的是公共教育和对先天性CMV感染的普遍性和对社会影响的认识。将通过包括受先天性疾病影响的家庭，为有兴趣的公共参与者和政策制定者提供一个有启发性的论坛来实现教育目标。我们预计，这次会议将吸引来自各种背景的参与者，从基本和工业研究人员到诊断和临床从业人员。值得注意的是，这次会议的主要目标是刺激跨学科 在先天性CMV感染中具有多种兴趣的科学家之间的交流以及 新的信息以教育公众关于这种长期忽视的疾病和通过疫苗预防期间的治疗前景。