Core--Pathology/Morphology/Imaging Facility

核心--病理/形态/影像设备

基本信息

批准号：
7392666
负责人：
Raymond B Baggs
金额：
$ 19.4万
依托单位：
UNIVERSITY OF ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/7392666
关键词：
Agreement Area Breathing Carbon Black Cardiac Cardiovascular system Cells Charge Cicatrix Clinical Research Control Animal Core Facility DNA Repair Disease Dissection Documentation Dust Endotoxins Environmental Pollutants Environmental Risk Factor Equipment Fibroblasts Fibrosis Fluorescence Microscopy Funding Gases Gene Expression Goals Grant Health Histology Home environment Human Image Immunochemistry In Situ Hybridization Incidence Individual Inflammation Inflammation Mediators Injury Integration Host Factors Ionizing radiation Lasers Lung Lung diseases Maintenance Molecular Morphology Nature Newborn Infant Occupational Oxidants Oxidative Stress Particle Size Particulate Matter Pathology Pneumonia Purpose Range Rattus Reagent Research Respiratory System Respiratory Tract Diseases Role Services Siloxanes Stress Supervision System TNFRSF1A gene Technical Expertise Techniques Therapeutic Intervention Tissues Toxicology Transgenic Organisms Universities Update Wound Healing Zinc Oxide age group aged ambient particle cigarette smoking design environmental agent instrument laser capture microdissection lung injury member morphometry multidisciplinary neonate novel therapeutics particle pollutant repaired response soft tissue therapy development ultrafine particle

项目摘要

Description (provided by applicant): The Pathology/Morphology/Imaging Facility provides the equipment and technical expertise in conducting studies involving histology, immunochemistry, in situ hybridization, confocal, laser dissection and morphometrics. Significant enhancements in its services have occurred over the previous funding period, including fluorescence microscopy, immunostaining, laser capture microdissection and other techniques. The facility is divided into a main lab for pathology/morphology, a molecular morphology lab for in situ hybridization of soft tissues, an immunostaining lab, and a hard tissue histology, morphometry and in situ hybridization of hard tissues. Confocal imaging is provided through a University Facilities Core lab. Each lab is overseen by a Center grant member who is physically located near the lab, and each of whom extensively uses the techniques of the lab under their supervision. The core is directed by Dr. Baggs, who is the initial contact for all potential users in a system designed to enhance the ease of use of this facility. Charges are levied according to affiliation with the EHSC or University of Rochester. Extensive documentation of use by members of the Center grant is provided. A major change in the nature of the facility is the partnering of the immunostaining lab with the Pathology department, which should allow more efficient use of instruments and reagents and guarantee the use of updated equipment through lease/maintenance agreements.

描述（申请人提供）：病理/形态/成像设施提供了进行涉及组织学，免疫化学，原位杂交，共聚焦，激光解剖和形态计量学的设备和技术专业知识。其服务的显着增强发生在上一个资金期间，包括荧光显微镜，免疫染色，激光捕获显微减退和其他技术。该设施分为病理学/形态的主要实验室，一种分子形态学实验室，用于原位杂交软组织，免疫染色实验室以及硬组织组织学，形态学和硬组织的原位杂交。共聚焦成像是通过大学设施核心实验室提供的。每个实验室都由一个物理位于实验室附近的中心赠款成员监督，每个实验室都在其监督下广泛使用实验室的技术。核心由Baggs博士指导，Baggs博士是该系统中所有潜在用户的初步联系，旨在提高此设施的易用性。根据与EHSC或罗切斯特大学的隶属关系征收指控。提供了中心赠款成员的大量使用文件。该设施性质的重大变化是免疫染色实验室与病理部的合作，该实验室应允许更有效地使用仪器和试剂，并通过租赁/维护协议保证使用更新的设备。