Translational Research Core

转化研究核心

基本信息

批准号：
7665016
负责人：
NEIL J KORMAN
金额：
$ 10.23万
依托单位：
CASE WESTERN RESERVE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-08-01 至 2011-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7665016
关键词：
Adjunct Clinical Trials Advertisements Antioxidants Area Biology Biopsy Blood Broadcast Media Clinical Clinical Data Clinical Research Clinical Trials Clinical Trials Design Communication Comprehensive Cancer Center Conduct Clinical Trials Core Facility Cutaneous Data Data Analyses Databases Dermatologic Dermatology Development Disease Dose Education Ensure Equipment Exposure to Faculty Fostering Goals Haptens Housing Human Human Subject Research In Vitro Individual Informed Consent Institution Intervention Invasive Investigation Laboratories Laboratory Study Manuscripts Measurement Monitor Numbers Nurses Oral Outcomes Research Pamphlets Patients Physicians Policies Preparation Printing Procedures Protocols documentation Records Recruitment Activity Research Research Design Research Ethics Committees Research Personnel Resources Safety Schedule Services Simulate Skin Skin Tissue Solar Energy Specimen Standards of Weights and Measures Sunscreening Agents Testing Tissues Topical agent Training Translational Research UV Radiation Exposure Ultrasonography United States Food and Drug Administration Universities Venipunctures Water base career cost design human study human subject in vivo interest non-invasive monitor novel posters research study skin disorder volunteer

项目摘要

The Translational Research Core is designed to promote and facilitate human subject research in skin biology and skin disease. The first aim is to provide a cost-efficient, central resource to identify and recruit volunteers to participate in human in vivo studies and/or donate blood or skin biopsy tissue for ex vivo/in vitro investigations. The Core performs procedures such as skin exposure to simulated solar radiation, hapten sensitization & elicitation, non-invasive monitoring (e.g., ultrasonography, chromometry, transepidermal water loss measurement) and tissue acquisition (venipuncture, punch & keratome biopsies). The utilization of these functions are expanded mainly by active interactions with physicians who refer patients and with other investigators through the Case Comprehensive Cancer Center, the General Clinical Research Center, Center for Aids Research, and other research foci within the University. A research assistant coordinates these services. The second aim is to provide overall management of clinical trials of novel therapies brought from the laboratory to the bedside with emphasis on providing optimal translational and clinical data. A group with expertise in general trial design as well as data and safety monitoring are assembled to efficiently direct or conduct high quality studies that arise through interaction with various investigators interested in skin research. Additionally, interactions between clinical and laboratory researchers are fostered to insert adjunctive laboratory studies to clarify mechanisms of action of therapies and pathomechanisms of disease. The third aim is to foster career development of young investigators and junior faculty in the area of human subject-based skin research. This involves providing support at multiple levels (e.g. IRB submission, protocol design, data analysis, manuscript preparation) depending on investigator needs.

翻译研究核心旨在促进和促进皮肤中的人类学科研究生物学和皮肤病。第一个目的是提供一种经济高效的中心资源来识别和招募自愿参加人体体内研究和/或捐赠血液或皮肤活检组织以进行体内/体外调查。核心执行的程序，例如皮肤暴露于模拟太阳辐射，触觉致敏和启发，非侵入性监测（例如，超声检查，镀铬，旋转术水分损失测量）和组织采集（静脉穿刺，打孔和角膜活检）。利用率这些功能的主要是通过与参考患者以及与患者的医生进行主动互动来扩展的通过案例综合癌症中心的其他研究人员，一般临床研究中心，艾滋病研究中心和大学内的其他研究重点。研究助理坐标这些服务。第二个目的是提供对带来的新型疗法的临床试验的总体管理从实验室到床边，重点是提供最佳的翻译和临床数据。一个在一般试验设计以及数据和安全监控方面具有专业知识的小组会有效地组装通过与感兴趣的各种研究人员互动而产生的直接或进行高质量研究皮肤研究。此外，培养临床和实验室研究人员之间的相互作用以插入辅助实验室研究，以阐明疗法和疾病病理机理的作用机理。第三个目的是促进人类领域的年轻调查员和初级教师的职业发展基于主题的皮肤研究。这涉及在多个级别提供支持（例如IRB提交，协议设计，数据分析，手稿准备）取决于研究者的需求。