Translational Research Core

转化研究核心

• 批准号: 8118111
• 负责人: NEIL J KORMAN
• 金额: $ 14.73万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8118111
• 关键词: Advertisements; Antioxidants; Area; Biology; Biopsy; Blood; Broadcast Media; Clinical; Clinical Data; Clinical Research; Clinical Trials; Clinical Trials Design; Communication; Comprehensive Cancer Center; Conduct Clinical Trials; Core Facility; Cutaneous; Data; Data Analyses; Databases; Dermatologic; Dermatology; Disease; Dose; Education; Ensure; Equipment; Exposure to; Faculty; Fostering; Goals; Haptens; Housing; Human; Human Subject Research; In Vitro; Individual; Informed Consent; Institution; Intervention; Investigation; Laboratories; Laboratory Study; Manuscripts; Measurement; Monitor; Nurses; Oral; Outcomes Research; Pamphlets; Patients; Physicians; Policies; Preparation; Printing; Procedures; Protocols documentation; Records; Recruitment Activity; Research; Research Design; Research Ethics Committees; Research Personnel; Resources; Safety; Schedule; Services; Simulate; Skin; Skin Tissue; Solar Energy; Specimen; Sunscreening Agents; Testing; Tissues; Topical agent; Training; Translational Research; UV Radiation Exposure; Ultrasonography; Universities; Venipunctures; Water; base; career development; cost; design; human study; human subject; in vivo; interest; non-invasive monitor; novel; posters; research study; skin disorder; volunteer

The Translational Research Core is designed to promote and facilitate human subject research in skin biology and skin disease. The first aim is to provide a cost-efficient, central resource to identify and recruit volunteers to participate in human in vivo studies and/or donate blood or skin biopsy tissue for ex vivo/in vitro investigations. The Core performs procedures such as skin exposure to simulated solar radiation, hapten sensitization & elicitation, non-invasive monitoring (e.g., ultrasonography, chromometry, transepidermal water loss measurement) and tissue acquisition (venipuncture, punch & keratome biopsies). The utilization of these functions are expanded mainly by active interactions with physicians who refer patients and with other investigators through the Case Comprehensive Cancer Center, the General Clinical Research Center, Center for Aids Research, and other research foci within the University. A research assistant coordinates these services. The second aim is to provide overall management of clinical trials of novel therapies brought from the laboratory to the bedside with emphasis on providing optimal translational and clinical data. A group with expertise in general trial design as well as data and safety monitoring are assembled to efficiently direct or conduct high quality studies that arise through interaction with various investigators interested in skin research. Additionally, interactions between clinical and laboratory researchers are fostered to insert adjunctive laboratory studies to clarify mechanisms of action of therapies and pathomechanisms of disease. The third aim is to foster career development of young investigators and junior faculty in the area of human subject-based skin research. This involves providing support at multiple levels (e.g. IRB submission, protocol design, data analysis, manuscript preparation) depending on investigator needs.

转化研究核心旨在促进和促进皮肤方面的人体研究 生物学和皮肤病。第一个目标是提供具有成本效益的中央资源来识别和招聘 志愿者参与人体体内研究和/或捐献血液或皮肤活检组织用于离体/体外 调查。核心执行诸如皮肤暴露于模拟太阳辐射、半抗原等程序 敏化和诱导、非侵入性监测（例如超声检查、比色法、经表皮 失水测量）和组织采集（静脉穿刺、打孔和角膜刀活组织检查）。利用率 这些功能的扩展主要是通过与转诊患者的医生和患者的积极互动来实现的。 其他研究人员通过案例综合癌症中心、普通临床研究中心、 艾滋病研究中心以及大学内的其他研究重点。研究助理协调 这些服务。第二个目标是提供新疗法临床试验的全面管理 从实验室到临床，重点是提供最佳的转化和临床数据。一个 聚集了在一般试验设计以及数据和安全监测方面具有专业知识的小组，以有效地 指导或进行高质量的研究，这些研究是通过与感兴趣的各种研究人员的互动而产生的 皮肤研究。此外，还促进临床和实验室研究人员之间的互动，以插入 辅助实验室研究，以阐明治疗的作用机制和疾病的病理机制。 第三个目标是促进人类领域年轻研究者和初级教师的职业发展 基于主题的皮肤研究。这涉及提供多个级别的支持（例如 IRB 提交、协议 设计、数据分析、稿件准备）取决于研究者的需要。