A Biopsychosocial Approach to Racial/Ethnic Differences in Menopausal Hot Flashes

更年期潮热种族/民族差异的生物心理社会方法

• 批准号: 7491673
• 负责人: REBECCA C THURSTON
• 金额: $ 15.31万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7491673
• 关键词: Address; Affect; African American; Age; Aging; Androgens; Area; Award; Biological; Biological Factors; Body Composition; Body Size; Body fat; Body mass index; Boxing; Cardiovascular system; Caucasians; Caucasoid Race; Clinical; Data; Data Analyses; Depressed mood; Development; Employee Strikes; Epidemiology; Esthesia; Estrogens; Ethnic Origin; Ethnic group; Face; Fatigue; Female; Flushing; Frequencies; Goals; Head and neck structure; Health; Heat Losses; Heating; Hormones; Hot flushes; Interdisciplinary Study; Intervention; Investigation; Life; Measurement; Measures; Menopausal hot flushes; Menopause; Mental Depression; Mentored Clinical Oncology Award; Mentored Clinical Scientist Award; Mentored Patient-Oriented Research Career Development Award; Mentors; Minority Groups; Modeling; Obesity; Ovarian; Pathway interactions; Patient Self-Report; Physiologic Thermoregulation; Physiological; Physiology; Population; Process; Public Health; Purpose; Quality of life; Race; Range; Relative (related person); Reporting; Research; Research Personnel; Research Training; Risk; Role; Secondary to; Severities; Sleep disturbances; Social Psychology; Sweat; Sweating; Symptoms; Theoretical model; Training; United States; Variant; Woman; Women' s Health; abdominal fat; biopsychosocial; cancer risk; career; depressive symptoms; experience; improved; middle age; older women; patient oriented research; psychologic; racial and ethnic; racial and ethnic disparities; racial/ethnic difference; reproductive; reproductive hormone; skills training; social; subcutaneous

DESCRIPTION (provided by applicant): The purpose of this proposed Mentored Patient-Oriented Research Career Development (K23) Award is to support the Candidate's long term career goal of conducting interdisciplinary research to characterize the biological, psychological, and social determinants of women's health during menopause. The specific objective of this award is to understand disparities in menopausal hot flashes. Hot flashes are a pressing public health issue among aging women. They are experienced by the majority of midlife women, are a leading determinant of quality of life, and are in need of safe and effective treatments. Like many health issues in the United States, hot flashes are overrepresented among key racial/ethnic minority groups. The training aims of this award are to build upon the Candidate's training in clinical health psychology and social epidemiology to address the primary training areas obesity/body composition and physiologic aspects of hot flashes and secondary training areas racial/ethnic disparities in health and longitudinal data analysis. Because the understanding of hot flashes has been limited by the incomplete understanding of hot flash physiology, proposed research will focus on one important biological factor relevant to racial/ethnic disparities in hot flashes: body size and composition. The Candidate will conduct an ancillary investigation to the Study of Women's Health Across the Nation applying physiologic and self-report measures of hot flashes to examine associations between body size/composition and hot flashes among African American and Caucasian midlife women. Secondary aims include examining aims include examining the role of reproductive hormones in this association and comparing the subjective reporting of physiologically measured hot flashes by body size/composition. Achieving these training and research objectives has the potential to clarify key mechanisms involved in hot flashes and to inform interventions for hot flashes to improve the lives of diverse women as they age. The skills, training, and data obtained from this award will support the Candidate's development as an independent investigator and an interdisciplinary women's midlife health expert, with particular expertise in hot flashes.

描述（由申请人提供）：这项拟议的指导的注重患者的研究职业发展（K23）奖的目的是支持候选人的长期职业目标，即进行跨学科研究以表征妇女健康期间生物学，心理和社会决定因素绝经。该奖项的具体目标是了解更年期潮热的差异。潮热是老龄妇女的紧迫公共卫生问题。他们是大多数中年妇女经历的，是生活质量的主要决定因素，需要安全有效的治疗。像美国许多健康问题一样，在关键的种族/族裔少数群体中，炎热闪烁代表过多。该奖项的培训目的是建立候选人在临床健康心理学和社会流行病学方面的培训，以解决肥胖/身体组成和潮热训练领域的肥胖/身体组成和生理方面以及次要培训领域的健康和族裔/族裔/族裔/族裔/纵向数据分析和纵向数据分析。由于对潮热的理解受到对热闪存生理学的不完全理解的限制，因此拟议的研究将重点放在与种族/种族差异有关的一个重要生物学因素上：体型和组成。候选人将对全国妇女健康的研究进行辅助调查，并采用生理和自我报告的潮热度量，以检查非洲裔美国人和高加索中年女性体型/成分和潮热之间的关联。次要目的包括检查目标包括检查生殖激素在该关联中的作用，并比较按身体大小/组成的生理测量闪光的主观报告。实现这些培训和研究目标有可能阐明潮热涉及的关键机制，并为潮热的干预提供介绍，以改善各种女性的生活。从该奖项获得的技能，培训和数据将支持候选人作为独立研究者和跨学科女性中年健康专家的发展，并在热潮方面具有特别的专业知识。