Genomics and Bioinformatics

基因组学和生物信息学

• 批准号: 7248227
• 负责人: LYNDA CHIN
• 金额: $ 12.9万
• 依托单位: DANA-FARBER CANCER INST
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7248227
• 关键词: Area; Arts; Bioinformatics; Biological; Biological Assay; Biometry; Candidate Disease Gene; Collaborations; Consultations; Core Facility; Custom; Dana-Farber Cancer Institute; Data; Data Storage and Retrieval; Emerging Technologies; Generations; Genes; Genetic; Genomics; Grant; Leadership; Mining; Molecular Profiling; Numbers; Process; Protocols documentation; Quality Control; Reproduction spores; Research Infrastructure; Research Personnel; Resolution; Resources; Role; Science; Services; Standards of Weights and Measures; Technical Expertise; Technology; Ursidae Family; cancer genomics; concept; design; improved; new technology; tool

Centralization of genomics-bioinformatics will provide the SPORE investigators with access to the state-of- the-art genomic capability and bioinformatics expertise, by leveraging existing institutional infrastructure such as Harvard/Partners Center for Genomics and Genetics and the Belfer Cancer Genomics Center. An important benefit derived from centralization comes from improved data storage and sharing, allowing for better integration of ideas and information across the various projects within the SPORE. Moreover, given the pace of discovery in areas of genomics and bioinformatics, it is difficult to predict where the field will stand even one year in advance. This invariant feature of change provides justification for a core with strong technical implementation capability and intellectual leadership throughout the granting period, so that the best technology will be brought to bear on the biological questions of the SPORE. This Core will provide several levels of support to the SPORE. First, it will offer bioinformatics consultation, in collaboration with Biostatistics, to assist all projects in the design and preliminary analyses of genomic studies, including copy number and expression profiling as well as gene re-sequencing. In this process, the Core will serve the central coordinating role in data receipt/storage for genomic assays in all projects, so that integrated analyses can be performed more easily. Second, the Core will leverage existing institutional infrastructure for established capabilities such as expression profiling and candidate gene re-sequencing. In addition, the Core will bring to the SPORE unique capability in high-resolution copy number profiling by array-CGH. Third, the Core will provide custom-designed tools and bioinformatics expertise for mining copy number data with integrated expression analyses.

基因组学-生物信息学的集中化将为 SPORE 研究人员提供了解最新状态的途径 通过利用现有的机构基础设施，例如，最先进的基因组能力和生物信息学专业知识 哈佛/合作伙伴基因组学和遗传学中心以及贝尔弗癌症基因组学中心。一个 集中化带来的重要好处来自于改进的数据存储和共享，从而允许 更好地整合 SPORE 内各个项目的想法和信息。此外，鉴于 基因组学和生物信息学领域的发现速度，很难预测该领域的发展方向 甚至提前一年。变化的这种不变特征为具有强大核心能力的核心提供了理由 整个授权期间的技术实施能力和智力领导力，使 最好的技术将被用来解决孢子的生物学问题。该核心将提供 对 SPORE 的多个级别的支持。首先，它将与以下机构合作提供生物信息学咨询： 生物统计学，协助所有项目进行基因组研究的设计和初步分析，包括复制 数量和表达谱以及基因重测序。在此过程中，Core将服务于 在所有项目的基因组分析数据接收/存储中发挥中心协调作用，以便整合 可以更轻松地进行分析。其次，核心将利用现有的机构基础设施 用于表达谱分析和候选基因重测序等已建立的功能。此外， Core 将为 SPORE 带来通过 array-CGH 进行高分辨率拷贝数分析的独特功能。第三， 该核心将提供定制设计的工具和生物信息学专业知识，用于挖掘拷贝数数据 综合表达分析。